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- W4361001431 abstract "Abstract Background: Epigenetic modification has provided novel insight for understanding the complex mechanism of psychiatric disorders. However, how m 6 A RNA methylation modification played a role in schizophrenia (SCZ) remains poorly understood. The aim of this study was to investigate the role of m 6 A modification and their relationship with the immune infiltration characteristics of SCZ. Methods: We searched the Gene Expression Omnibus (GEO) database. Finally, 391 postmortem brains of SCZ were used to assess the differential expression level of m 6 A methylation regulators between SCZ and controls. The relative expression abundance of immune cells and immune functions was examined by Single-Sample Gene Set Enrichment Analysis (ssGSEA). Results: We found significant differences in the expression levels of m 6 A regulators between SCZ and controls. Logistic-LASSO regression analysis identified the 6 key m 6 A regulators, and the risk scores could well distinguish SCZ and controls. There were significant differences in immune cells and immune functions. We identified 4 potential m 6 A methylation modification key genes of SCZ. Conclusion: Our study demonstrated that m 6 A regulators and immune infiltration characteristics might play an important role in the pathogenesis of SCZ. However, we need more clinical evidence to validate these found." @default.
- W4361001431 created "2023-03-30" @default.
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- W4361001431 date "2023-03-27" @default.
- W4361001431 modified "2023-10-18" @default.
- W4361001431 title "Analysis of m6A regulator-mediated RNA methylation modification patterns and immune infiltration characterization in schizophrenia" @default.
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- W4361001431 doi "https://doi.org/10.21203/rs.3.rs-2673810/v1" @default.
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