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- W4361001491 abstract "Abstract Mast cells (MCs) are multifaceted innate immune cells often present in the tumor microenvironment (TME). Several recent findings support their contribution in the transition from chronic inflammation to cancer. However, MC-derived mediators can either favor tumor progression, inducing spread of the tumor, or exert anti-tumorigenic functions, limiting tumor growth. This apparent controversial role likely depends on the plastic nature of MCs that under different microenvironmental stimuli can rapidly change their phenotype and functions. Thus, the exact effect of unique MC subset(s) during tumor progression is far from being understood. Using a murine model of colitis-associated colorectal cancer, we initially characterized MC population within the TME and in non-lesional colonic areas, by multicolor flow cytometry and confocal microscopy. Our results demonstrated that tumor-associated MCs harbor a main connective tissue phenotype and release high amounts of Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)a. This MC phenotype correlates with the presence of high levels of Stem Cell Factor (SCF) and IL33 inside the tumor. Thus, we investigated the effect of SCF and IL-33 on primary MC cultures and underscore their ability to shape MC phenotype eliciting the production of pro-inflammatory cytokines. Our findings support the conclusion that during colonic transformation a sustained stimulation by SCF and IL-33 promotes the accumulation of a prevalent connective tissue-like MC subset that through the secretion of IL-6 and TNF-a maintains a pro-inflammatory microenvironment." @default.
- W4361001491 created "2023-03-30" @default.
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- W4361001491 date "2023-03-27" @default.
- W4361001491 modified "2023-10-13" @default.
- W4361001491 title "SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment" @default.
- W4361001491 doi "https://doi.org/10.21203/rs.3.rs-2648698/v1" @default.
- W4361001491 hasPublicationYear "2023" @default.
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