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- W4361002046 endingPage "579" @default.
- W4361002046 startingPage "566" @default.
- W4361002046 abstract "Abstract Long noncoding RNAs (lncRNAs) are emerging players in cancer and they entail potential as prognostic biomarkers or therapeutic targets. Earlier studies have identified somatic mutations in lncRNAs that are associated with tumor relapse after therapy, but the underlying mechanisms behind these associations remain unknown. Given the relevance of secondary structure for the function of some lncRNAs, some of these mutations may have a functional impact through structural disturbance. Here, we examined the potential structural and functional impact of a novel A > G point mutation in NEAT1 that has been recurrently observed in tumors of colorectal cancer patients experiencing relapse after treatment. Here, we used the nextPARS structural probing approach to provide first empirical evidence that this mutation alters NEAT1 structure. We further evaluated the potential effects of this structural alteration using computational tools and found that this mutation likely alters the binding propensities of several NEAT1 ‐interacting miRNAs. Differential expression analysis on these miRNA networks shows upregulation of Vimentin , consistent with previous findings. We propose a hybrid pipeline that can be used to explore the potential functional effects of lncRNA somatic mutations." @default.
- W4361002046 created "2023-03-30" @default.
- W4361002046 creator A5003394700 @default.
- W4361002046 creator A5037512607 @default.
- W4361002046 creator A5048708321 @default.
- W4361002046 creator A5051408606 @default.
- W4361002046 date "2023-03-27" @default.
- W4361002046 modified "2023-10-07" @default.
- W4361002046 title "A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key <scp><i>NEAT1</i></scp> interactions in colorectal cancer" @default.
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