FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361002448> ?p ?o ?g. }

• W4361002448 endingPage "953" @default.
• W4361002448 startingPage "948" @default.
• W4361002448 abstract "ABSTRACT. Enterotoxigenic Escherichia coli (ETEC) ranks among the most relevant diarrheagenic pathogens. Efforts to design vaccines to fight ETEC have been focused on colonizing factors (CFs) and atypical virulence factors (AVF). An effective vaccine must account for differences in the regional prevalence of these CFs and AVFs to be truly effective in a given area. In the present study, the presence of 16 CFs and 9 AVFs, as well as the heat-stable (ST) variants (STh or STp), was established by polymerase chain reaction in 205 Peruvian ETEC isolates (120 from diarrhea cases and 85 from healthy controls). Ninety-nine (48.3%) isolates were heat-labile, 63 (30.7%) ST, and 43 (21.0%) presented both toxins. Of ST isolates, 59 (28.8%) possessed STh, 30 (14.6%) STp, five (2.4%) both STh and STp, and 12 (5.8%) were not amplified for any variant tested. The presence of CFs was associated with diarrhea ( P < 0.0001). The presence of eatA as well as concomitant presence of CSI, CS3, and CS21 and of C5 and C6 was statistically related to diarrhea cases. The present results suggests that, if effective, a vaccine considering CS6, CS20, and CS21, together with EtpA, would provide protection against 64.4% of the isolates analyzed, whereas the addition of CS12 and EAST1 would lead to 83.9% coverage. Large studies are needed to establish both the ideal candidates to be considered to develop a vaccine effective in the area, and continuous surveillance is needed to detect displacement of circulating isolates that may compromise future vaccines." @default.
• W4361002448 created "2023-03-30" @default.
• W4361002448 creator A5006962288 @default.
• W4361002448 creator A5018331168 @default.
• W4361002448 creator A5022125217 @default.
• W4361002448 creator A5050157959 @default.
• W4361002448 creator A5062130746 @default.
• W4361002448 creator A5088273605 @default.
• W4361002448 date "2023-05-03" @default.
• W4361002448 modified "2023-10-18" @default.
• W4361002448 title "Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru" @default.
• W4361002448 cites W1971924674 @default.
• W4361002448 cites W1979699055 @default.
• W4361002448 cites W2004537271 @default.
• W4361002448 cites W2055798634 @default.
• W4361002448 cites W2062734626 @default.
• W4361002448 cites W2063508670 @default.
• W4361002448 cites W2078531092 @default.
• W4361002448 cites W2079031703 @default.
• W4361002448 cites W2103318802 @default.
• W4361002448 cites W2110930132 @default.
• W4361002448 cites W2112111992 @default.
• W4361002448 cites W2112432314 @default.
• W4361002448 cites W2136698980 @default.
• W4361002448 cites W2138518611 @default.
• W4361002448 cites W2142586833 @default.
• W4361002448 cites W2166782347 @default.
• W4361002448 cites W2167021159 @default.
• W4361002448 cites W2228691457 @default.
• W4361002448 cites W2395023835 @default.
• W4361002448 cites W2607924308 @default.
• W4361002448 cites W2620403329 @default.
• W4361002448 cites W2626057099 @default.
• W4361002448 cites W2762322801 @default.
• W4361002448 cites W2793908185 @default.
• W4361002448 cites W2891808294 @default.
• W4361002448 cites W2907449572 @default.
• W4361002448 cites W3014242150 @default.
• W4361002448 cites W3021655250 @default.
• W4361002448 cites W3036605731 @default.
• W4361002448 cites W310820143 @default.
• W4361002448 cites W3195353462 @default.
• W4361002448 cites W3208616467 @default.
• W4361002448 cites W3214436431 @default.
• W4361002448 cites W4200237433 @default.
• W4361002448 cites W4220692354 @default.
• W4361002448 cites W4280498472 @default.
• W4361002448 doi "https://doi.org/10.4269/ajtmh.22-0677" @default.
• W4361002448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36972692" @default.
• W4361002448 hasPublicationYear "2023" @default.
• W4361002448 type Work @default.
• W4361002448 citedByCount "0" @default.
• W4361002448 crossrefType "journal-article" @default.
• W4361002448 hasAuthorship W4361002448A5006962288 @default.
• W4361002448 hasAuthorship W4361002448A5018331168 @default.
• W4361002448 hasAuthorship W4361002448A5022125217 @default.
• W4361002448 hasAuthorship W4361002448A5050157959 @default.
• W4361002448 hasAuthorship W4361002448A5062130746 @default.
• W4361002448 hasAuthorship W4361002448A5088273605 @default.
• W4361002448 hasBestOaLocation W43610024481 @default.
• W4361002448 hasConcept C104317684 @default.
• W4361002448 hasConcept C126322002 @default.
• W4361002448 hasConcept C159047783 @default.
• W4361002448 hasConcept C2777871010 @default.
• W4361002448 hasConcept C2779802037 @default.
• W4361002448 hasConcept C49105822 @default.
• W4361002448 hasConcept C54355233 @default.
• W4361002448 hasConcept C547475151 @default.
• W4361002448 hasConcept C60987743 @default.
• W4361002448 hasConcept C61716771 @default.
• W4361002448 hasConcept C66999527 @default.
• W4361002448 hasConcept C71924100 @default.
• W4361002448 hasConcept C86803240 @default.
• W4361002448 hasConcept C89423630 @default.
• W4361002448 hasConceptScore W4361002448C104317684 @default.
• W4361002448 hasConceptScore W4361002448C126322002 @default.
• W4361002448 hasConceptScore W4361002448C159047783 @default.
• W4361002448 hasConceptScore W4361002448C2777871010 @default.
• W4361002448 hasConceptScore W4361002448C2779802037 @default.
• W4361002448 hasConceptScore W4361002448C49105822 @default.
• W4361002448 hasConceptScore W4361002448C54355233 @default.
• W4361002448 hasConceptScore W4361002448C547475151 @default.
• W4361002448 hasConceptScore W4361002448C60987743 @default.
• W4361002448 hasConceptScore W4361002448C61716771 @default.
• W4361002448 hasConceptScore W4361002448C66999527 @default.
• W4361002448 hasConceptScore W4361002448C71924100 @default.
• W4361002448 hasConceptScore W4361002448C86803240 @default.
• W4361002448 hasConceptScore W4361002448C89423630 @default.
• W4361002448 hasIssue "5" @default.
• W4361002448 hasLocation W43610024481 @default.
• W4361002448 hasLocation W43610024482 @default.
• W4361002448 hasOpenAccess W4361002448 @default.
• W4361002448 hasPrimaryLocation W43610024481 @default.
• W4361002448 hasRelatedWork W2128378133 @default.
• W4361002448 hasRelatedWork W2138645094 @default.
• W4361002448 hasRelatedWork W2146630123 @default.
• W4361002448 hasRelatedWork W2318106903 @default.
• W4361002448 hasRelatedWork W2329402950 @default.

• next