Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361002734> ?p ?o ?g. }
- W4361002734 endingPage "744" @default.
- W4361002734 startingPage "730" @default.
- W4361002734 abstract "Abstract Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the other CA subregions. Notably, this includes a lack of typical long‐term potentiation of stratum radiatum synapses. CA2 neurons express high levels of several known and potential regulators of metabotropic glutamate receptor (mGluR)‐dependent signaling including Striatal‐Enriched Tyrosine Phosphatase (STEP) and several Regulator of G‐protein Signaling (RGS) proteins, yet the functions of these proteins in regulating mGluR‐dependent synaptic plasticity in CA2 are completely unknown. Thus, the aim of this study was to examine mGluR‐dependent synaptic depression and to determine whether STEP and the RGS proteins RGS4 and RGS14 are involved. Using whole cell voltage‐clamp recordings from mouse pyramidal cells, we found that mGluR agonist‐induced long‐term depression (mGluR‐LTD) is more pronounced in CA2 compared with that observed in CA1. This mGluR‐LTD in CA2 was found to be protein synthesis and STEP dependent, suggesting that CA2 mGluR‐LTD shares mechanistic processes with those seen in CA1, but in addition, RGS14, but not RGS4, was essential for mGluR‐LTD in CA2. In addition, we found that exogenous application of STEP could rescue mGluR‐LTD in RGS14 KO slices. Supporting a role for CA2 synaptic plasticity in social cognition, we found that RGS14 KO mice had impaired social recognition memory as assessed in a social discrimination task. These results highlight possible roles for mGluRs, RGS14, and STEP in CA2‐dependent behaviors, perhaps by biasing the dominant form of synaptic plasticity away from LTP and toward LTD in CA2." @default.
- W4361002734 created "2023-03-30" @default.
- W4361002734 creator A5001113992 @default.
- W4361002734 creator A5005573844 @default.
- W4361002734 creator A5005594487 @default.
- W4361002734 creator A5021014206 @default.
- W4361002734 creator A5057620041 @default.
- W4361002734 creator A5061425726 @default.
- W4361002734 creator A5066076452 @default.
- W4361002734 creator A5069054132 @default.
- W4361002734 creator A5070115071 @default.
- W4361002734 creator A5072547059 @default.
- W4361002734 creator A5081196882 @default.
- W4361002734 creator A5084628160 @default.
- W4361002734 date "2023-03-27" @default.
- W4361002734 modified "2023-09-28" @default.
- W4361002734 title "Mechanisms of <scp>mGluR</scp>‐dependent plasticity in hippocampal area <scp>CA2</scp>" @default.
- W4361002734 cites W1504431166 @default.
- W4361002734 cites W1533181711 @default.
- W4361002734 cites W1600525795 @default.
- W4361002734 cites W1601653849 @default.
- W4361002734 cites W1615495952 @default.
- W4361002734 cites W1660095449 @default.
- W4361002734 cites W1834174605 @default.
- W4361002734 cites W1887484017 @default.
- W4361002734 cites W1896569873 @default.
- W4361002734 cites W1967017832 @default.
- W4361002734 cites W1971023423 @default.
- W4361002734 cites W1979266787 @default.
- W4361002734 cites W1980283082 @default.
- W4361002734 cites W1982624291 @default.
- W4361002734 cites W1983228276 @default.
- W4361002734 cites W1987647465 @default.
- W4361002734 cites W1988601231 @default.
- W4361002734 cites W1989031138 @default.
- W4361002734 cites W1989256353 @default.
- W4361002734 cites W1993109240 @default.
- W4361002734 cites W1996649058 @default.
- W4361002734 cites W2000309815 @default.
- W4361002734 cites W2003083934 @default.
- W4361002734 cites W2009863539 @default.
- W4361002734 cites W2011504521 @default.
- W4361002734 cites W2021235911 @default.
- W4361002734 cites W2031785254 @default.
- W4361002734 cites W2034262866 @default.
- W4361002734 cites W2039668561 @default.
- W4361002734 cites W2042834556 @default.
- W4361002734 cites W2044973052 @default.
- W4361002734 cites W2051323125 @default.
- W4361002734 cites W2052594402 @default.
- W4361002734 cites W2059317862 @default.
- W4361002734 cites W2061099385 @default.
- W4361002734 cites W2061405268 @default.
- W4361002734 cites W2069948297 @default.
- W4361002734 cites W2072818925 @default.
- W4361002734 cites W2079862834 @default.
- W4361002734 cites W2080252952 @default.
- W4361002734 cites W2087078319 @default.
- W4361002734 cites W2092956762 @default.
- W4361002734 cites W2099540110 @default.
- W4361002734 cites W2108563170 @default.
- W4361002734 cites W2117023704 @default.
- W4361002734 cites W2122230301 @default.
- W4361002734 cites W2123491442 @default.
- W4361002734 cites W2134736026 @default.
- W4361002734 cites W2135744973 @default.
- W4361002734 cites W2165312126 @default.
- W4361002734 cites W2169294911 @default.
- W4361002734 cites W2169371082 @default.
- W4361002734 cites W2227829864 @default.
- W4361002734 cites W2259382320 @default.
- W4361002734 cites W2339057475 @default.
- W4361002734 cites W2346506470 @default.
- W4361002734 cites W2508899024 @default.
- W4361002734 cites W2517284159 @default.
- W4361002734 cites W2742459817 @default.
- W4361002734 cites W2759357790 @default.
- W4361002734 cites W2789455277 @default.
- W4361002734 cites W2902511506 @default.
- W4361002734 cites W2944035776 @default.
- W4361002734 cites W2951512361 @default.
- W4361002734 cites W2957162493 @default.
- W4361002734 cites W2980064591 @default.
- W4361002734 cites W3016370003 @default.
- W4361002734 cites W3089879296 @default.
- W4361002734 cites W3095222604 @default.
- W4361002734 cites W3173793063 @default.
- W4361002734 cites W3176823604 @default.
- W4361002734 cites W3181385353 @default.
- W4361002734 cites W4200130917 @default.
- W4361002734 cites W4286256609 @default.
- W4361002734 cites W4312093758 @default.
- W4361002734 cites W751975581 @default.
- W4361002734 doi "https://doi.org/10.1002/hipo.23529" @default.
- W4361002734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36971428" @default.
- W4361002734 hasPublicationYear "2023" @default.
- W4361002734 type Work @default.
- W4361002734 citedByCount "1" @default.