Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361002816> ?p ?o ?g. }
- W4361002816 endingPage "1020" @default.
- W4361002816 startingPage "1020" @default.
- W4361002816 abstract "In recent years, immune checkpoint inhibitors (ICIs) have revolutionized the treatment of patients with hepatocellular carcinoma (HCC). Following the positive results of the IMbrave150 trial, the combination of atezolizumab (an anti-PD-L1 antibody) and bevacizumab (an anti-VEGF antibody) became the standard of care frontline treatment for patients with advanced stage HCC. Several other trials evaluated immunotherapy in HCC, demonstrating that ICIs-based regimens are currently the most effective treatment strategies and expanding the therapeutic possibilities. Despite the unprecedent rates of objective tumor response, not all patients benefit from treatment with ICIs. Therefore, in order to select the appropriate therapy as well as to correctly allocate medical resources and avoid unnecessary treatment-related toxicities, there is great interest in identifying the predictive biomarkers of response or resistance to immunotherapy-based regimens. Immune classes of HCC, genomic signatures, anti-drug antibodies, and patient-related factors (e.g., etiology of liver disease, gut microbiota diversity) have been associated to the response to ICIs, but none of the proposed biomarkers have been translated into clinical practice so far. Considering the crucial importance of this topic, in this review we aim to summarize the available data on tumor and clinical features associated with the response or resistance of HCC to immunotherapies." @default.
- W4361002816 created "2023-03-30" @default.
- W4361002816 creator A5000973050 @default.
- W4361002816 creator A5030619209 @default.
- W4361002816 creator A5065572516 @default.
- W4361002816 date "2023-03-27" @default.
- W4361002816 modified "2023-10-05" @default.
- W4361002816 title "Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Strategies and Biomarkers Predicting Response and/or Resistance" @default.
- W4361002816 cites W1480508732 @default.
- W4361002816 cites W1536480181 @default.
- W4361002816 cites W1971837077 @default.
- W4361002816 cites W1982488143 @default.
- W4361002816 cites W1987288591 @default.
- W4361002816 cites W1994193851 @default.
- W4361002816 cites W1994993231 @default.
- W4361002816 cites W2011435204 @default.
- W4361002816 cites W2021472146 @default.
- W4361002816 cites W2036922484 @default.
- W4361002816 cites W2039123767 @default.
- W4361002816 cites W2049491375 @default.
- W4361002816 cites W2049553585 @default.
- W4361002816 cites W2052730188 @default.
- W4361002816 cites W2062398277 @default.
- W4361002816 cites W2079018735 @default.
- W4361002816 cites W2085153086 @default.
- W4361002816 cites W2087304127 @default.
- W4361002816 cites W2104885590 @default.
- W4361002816 cites W2116169737 @default.
- W4361002816 cites W2122507780 @default.
- W4361002816 cites W2132406938 @default.
- W4361002816 cites W2143772132 @default.
- W4361002816 cites W2160834915 @default.
- W4361002816 cites W2166329890 @default.
- W4361002816 cites W2201214180 @default.
- W4361002816 cites W2289712604 @default.
- W4361002816 cites W2329974159 @default.
- W4361002816 cites W2340636398 @default.
- W4361002816 cites W2499029168 @default.
- W4361002816 cites W2527905628 @default.
- W4361002816 cites W2529308344 @default.
- W4361002816 cites W2557336488 @default.
- W4361002816 cites W2558219863 @default.
- W4361002816 cites W2559382297 @default.
- W4361002816 cites W2560367415 @default.
- W4361002816 cites W2572174216 @default.
- W4361002816 cites W2574604975 @default.
- W4361002816 cites W2586399611 @default.
- W4361002816 cites W2606367731 @default.
- W4361002816 cites W2626033245 @default.
- W4361002816 cites W2626773261 @default.
- W4361002816 cites W2724264513 @default.
- W4361002816 cites W2754479248 @default.
- W4361002816 cites W2754555655 @default.
- W4361002816 cites W2758825393 @default.
- W4361002816 cites W2760825739 @default.
- W4361002816 cites W2761575992 @default.
- W4361002816 cites W2779221466 @default.
- W4361002816 cites W2791060618 @default.
- W4361002816 cites W2791328450 @default.
- W4361002816 cites W2791483720 @default.
- W4361002816 cites W2792414950 @default.
- W4361002816 cites W2794713051 @default.
- W4361002816 cites W2796207838 @default.
- W4361002816 cites W2796227807 @default.
- W4361002816 cites W2797410539 @default.
- W4361002816 cites W2800992604 @default.
- W4361002816 cites W2802645166 @default.
- W4361002816 cites W2804448077 @default.
- W4361002816 cites W2805592007 @default.
- W4361002816 cites W2809962140 @default.
- W4361002816 cites W2883204623 @default.
- W4361002816 cites W2899174828 @default.
- W4361002816 cites W2899537750 @default.
- W4361002816 cites W2908573150 @default.
- W4361002816 cites W2908902954 @default.
- W4361002816 cites W2909679049 @default.
- W4361002816 cites W2914335731 @default.
- W4361002816 cites W2914486061 @default.
- W4361002816 cites W2924359886 @default.
- W4361002816 cites W2943041940 @default.
- W4361002816 cites W2952311394 @default.
- W4361002816 cites W2957852424 @default.
- W4361002816 cites W2963245811 @default.
- W4361002816 cites W2969583426 @default.
- W4361002816 cites W2969846817 @default.
- W4361002816 cites W2981320816 @default.
- W4361002816 cites W2990602950 @default.
- W4361002816 cites W2991341799 @default.
- W4361002816 cites W2997215171 @default.
- W4361002816 cites W2998269674 @default.
- W4361002816 cites W2998330412 @default.
- W4361002816 cites W2999153903 @default.
- W4361002816 cites W3003378907 @default.
- W4361002816 cites W3004964052 @default.
- W4361002816 cites W3005537740 @default.
- W4361002816 cites W3008514541 @default.
- W4361002816 cites W3010993117 @default.
- W4361002816 cites W3025022288 @default.