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- W4361003003 abstract "Abstract A previous quantum chemical study (M. Bracker et al., Phys. Chem. Chem. Phys . 2019 , 21 , 9912–9923) on the excited state properties of fluorinated derivatives of the flavin chromophore promised an increased fluorescence performance of the derivative 7,8‐difluoro‐10‐methyl‐isoalloxazine (7,8‐dF‐MIA). Here, we describe the synthesis of 7,8‐dF‐MIA, its ribityl derivative, and for reason of comparison 9‐F‐MIA. The compounds dissolved in water (H 2 O and D 2 O) were characterized by steady state, time resolved, and fluorescence correlation spectroscopy. The experiments confirm the increase of the fluorescence quantum yield of 7,8‐dF‐MIA (0.42 in H 2 O) compared to MIA (0.22) predicted by quantum chemistry. The anticipated reduction of the fluorescence quantum yield for 9‐F‐MIA is also confirmed experimentally. The quantum chemical computations as well as the spectroscopic observations attribute the increased fluorescence quantum yield of 7,8‐dF‐MIA predominantly to a decrease of the rate constant of intersystem crossing. Switching from H 2 O to D 2 O as a solvent is shown to increase fluorescence quantum yields (0.53 for 7,8‐dF‐MIA) and lifetimes of all fluorinated MIA derivatives. This can be attributed to a Förster type energy transfer from the excited chromophore to vibrational overtones of water and further water‐mediated deactivation processes." @default.
- W4361003003 created "2023-03-30" @default.
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- W4361003003 date "2023-05-15" @default.
- W4361003003 modified "2023-10-17" @default.
- W4361003003 title "Increasing the Fluorescence Quantum Yield and Lifetime of the Flavin Chromophore by Rational Design" @default.
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- W4361003003 doi "https://doi.org/10.1002/cptc.202200334" @default.
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