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- W4361003736 abstract "Histone acetylation is a pivotal epigenetic modification that controls chromatin structure and regulates gene expression. It plays an essential role in modulating zygotic transcription and cell lineage specification of developing embryos. While the outcomes of many inductive signals have been described to require enzymatic activities of histone acetyltransferases and deacetylases (HDACs), the mechanisms by which HDACs confine the utilization of the zygotic genome remain to be elucidated. Here, we show that histone deacetylase 1 (Hdac1) progressively binds to the zygotic genome from mid-blastula and onward. The recruitment of Hdac1 to the genome at blastula is instructed maternally. Cis-regulatory modules (CRMs) bound by Hdac1 possess epigenetic signatures underlying distinct functions. We highlight a dual function model of Hdac1 where Hdac1 not only represses gene expression by sustaining a histone hypoacetylation state on inactive chromatin, but also maintains gene expression through participating in dynamic histone acetylation-deacetylation cycles on active chromatin. As a result, Hdac1 maintains differential histone acetylation states of bound CRMs between different germ layers and reinforces the transcriptional program underlying cell lineage identities, both in time and space. Taken together, our study reveals a comprehensive role for Hdac1 during early vertebrate embryogenesis." @default.
- W4361003736 created "2023-03-30" @default.
- W4361003736 creator A5002864551 @default.
- W4361003736 creator A5016354648 @default.
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- W4361003736 creator A5033831242 @default.
- W4361003736 creator A5074829260 @default.
- W4361003736 creator A5078572492 @default.
- W4361003736 date "2023-03-27" @default.
- W4361003736 modified "2023-10-09" @default.
- W4361003736 title "Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis" @default.
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