Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361004021> ?p ?o ?g. }
- W4361004021 abstract "Objective: To investigate the effects of EGFR-TKI combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage-IV lung adenocarcinoma.
 Methods: This retrospective observational study included 116 patients with stage-IV lung adenocarcinoma, treated in The First Affiliated Hospital of Soochow University from January 2021 to January 2022. According to the treatment records, 60 patients that received pemetrexed + cisplatin for four courses were set as a Control-group and 56 patients that received EGFR-TKI + pemetrexed + cisplatin for four courses were set as an Observation-group. Changes in immune function, tumor marker levels and oxidative stress level in the two groups were analyzed and compared.
 Results: After the treatment, levels of CD3+, CD4+, IgG and IgM in the Control-group were significantly lower than those before the treatment. EGFR-TKI + pemetrexed + cisplatin resulted in levels of CD3+, CD4+, IgG and IgM higher than before the treatment, and compared to the Control-group (p<0.001). After the treatment, the levels of NSE, serum CEA, serum CA125, CYFEA21-1 in both groups were significantly lower than those before treatment, and lower in the Observation-group (p<0.001). After the treatment, VEGF and MMP9 levels in both groups were significantly lower than those before treatment, and markedly lower in the Observation-group (p<0.001).
 Conclusion: Compared with systemic chemotherapy, EGFR-TKI targeted combined chemotherapy for stage-IV lung adenocarcinoma is associated with enhanced immune function of patients. It more effectively inhibits the growth and proliferation of tumor cells and reduces the level of oxidative stress.
 doi: https://doi.org/10.12669/pjms.39.3.7397
 How to cite this: Kun Y, Wu J, Chen S. Effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeted combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage IV lung adenocarcinoma. Pak J Med Sci. 2023;39(3):742-746. doi: https://doi.org/10.12669/pjms.39.3.7397
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited." @default.
- W4361004021 created "2023-03-30" @default.
- W4361004021 creator A5028512303 @default.
- W4361004021 creator A5073884790 @default.
- W4361004021 creator A5084524299 @default.
- W4361004021 date "2023-03-27" @default.
- W4361004021 modified "2023-09-28" @default.
- W4361004021 title "Effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeted combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage IV lung adenocarcinoma" @default.
- W4361004021 cites W2299729500 @default.
- W4361004021 cites W2409185593 @default.
- W4361004021 cites W2560079673 @default.
- W4361004021 cites W2608627006 @default.
- W4361004021 cites W2773042583 @default.
- W4361004021 cites W2794613071 @default.
- W4361004021 cites W2888980789 @default.
- W4361004021 cites W2904314305 @default.
- W4361004021 cites W2911705731 @default.
- W4361004021 cites W2921311804 @default.
- W4361004021 cites W2947480172 @default.
- W4361004021 cites W2979785178 @default.
- W4361004021 cites W3003649900 @default.
- W4361004021 cites W3082376918 @default.
- W4361004021 cites W3095947917 @default.
- W4361004021 cites W3108583367 @default.
- W4361004021 cites W3111444440 @default.
- W4361004021 cites W3113295996 @default.
- W4361004021 cites W3185432721 @default.
- W4361004021 cites W3195481677 @default.
- W4361004021 cites W3208834979 @default.
- W4361004021 cites W3213835982 @default.
- W4361004021 cites W3214003785 @default.
- W4361004021 cites W4206784414 @default.
- W4361004021 cites W4210716527 @default.
- W4361004021 cites W4220731986 @default.
- W4361004021 cites W4220788826 @default.
- W4361004021 cites W4220903368 @default.
- W4361004021 cites W4220951137 @default.
- W4361004021 cites W4224052986 @default.
- W4361004021 cites W4226181569 @default.
- W4361004021 cites W4282916265 @default.
- W4361004021 cites W4287506720 @default.
- W4361004021 cites W4292680507 @default.
- W4361004021 doi "https://doi.org/10.12669/pjms.39.3.7397" @default.
- W4361004021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37250563" @default.
- W4361004021 hasPublicationYear "2023" @default.
- W4361004021 type Work @default.
- W4361004021 citedByCount "0" @default.
- W4361004021 crossrefType "journal-article" @default.
- W4361004021 hasAuthorship W4361004021A5028512303 @default.
- W4361004021 hasAuthorship W4361004021A5073884790 @default.
- W4361004021 hasAuthorship W4361004021A5084524299 @default.
- W4361004021 hasBestOaLocation W43610040211 @default.
- W4361004021 hasConcept C121608353 @default.
- W4361004021 hasConcept C126322002 @default.
- W4361004021 hasConcept C143998085 @default.
- W4361004021 hasConcept C146357865 @default.
- W4361004021 hasConcept C151730666 @default.
- W4361004021 hasConcept C203014093 @default.
- W4361004021 hasConcept C2776151105 @default.
- W4361004021 hasConcept C2776694085 @default.
- W4361004021 hasConcept C2777240266 @default.
- W4361004021 hasConcept C2778239845 @default.
- W4361004021 hasConcept C2781182431 @default.
- W4361004021 hasConcept C71924100 @default.
- W4361004021 hasConcept C86803240 @default.
- W4361004021 hasConcept C8891405 @default.
- W4361004021 hasConcept C90924648 @default.
- W4361004021 hasConceptScore W4361004021C121608353 @default.
- W4361004021 hasConceptScore W4361004021C126322002 @default.
- W4361004021 hasConceptScore W4361004021C143998085 @default.
- W4361004021 hasConceptScore W4361004021C146357865 @default.
- W4361004021 hasConceptScore W4361004021C151730666 @default.
- W4361004021 hasConceptScore W4361004021C203014093 @default.
- W4361004021 hasConceptScore W4361004021C2776151105 @default.
- W4361004021 hasConceptScore W4361004021C2776694085 @default.
- W4361004021 hasConceptScore W4361004021C2777240266 @default.
- W4361004021 hasConceptScore W4361004021C2778239845 @default.
- W4361004021 hasConceptScore W4361004021C2781182431 @default.
- W4361004021 hasConceptScore W4361004021C71924100 @default.
- W4361004021 hasConceptScore W4361004021C86803240 @default.
- W4361004021 hasConceptScore W4361004021C8891405 @default.
- W4361004021 hasConceptScore W4361004021C90924648 @default.
- W4361004021 hasIssue "3" @default.
- W4361004021 hasLocation W43610040211 @default.
- W4361004021 hasLocation W43610040212 @default.
- W4361004021 hasOpenAccess W4361004021 @default.
- W4361004021 hasPrimaryLocation W43610040211 @default.
- W4361004021 hasRelatedWork W2136403887 @default.
- W4361004021 hasRelatedWork W2355793859 @default.
- W4361004021 hasRelatedWork W2356818136 @default.
- W4361004021 hasRelatedWork W2383191656 @default.
- W4361004021 hasRelatedWork W2413537020 @default.
- W4361004021 hasRelatedWork W2591408645 @default.
- W4361004021 hasRelatedWork W2999684312 @default.
- W4361004021 hasRelatedWork W3032772405 @default.
- W4361004021 hasRelatedWork W4250822077 @default.
- W4361004021 hasRelatedWork W2102678840 @default.
- W4361004021 hasVolume "39" @default.
- W4361004021 isParatext "false" @default.
- W4361004021 isRetracted "false" @default.