FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361004076> ?p ?o ?g. }

• W4361004076 endingPage "1622" @default.
• W4361004076 startingPage "1622" @default.
• W4361004076 abstract "Background Calorie restriction is recognized as a useful nutritional approach to improve the endocrine derangements and low fertility profile associated with increased body weight. This is particularly the case for dietary regimens involving ketosis, resulting in increased serum levels of ketone bodies such as β-hydroxy-butyrate (β-HB). In addition to serum, β-HB is detected in several biofluids and β-HB levels in the follicular fluid are strictly correlated with the reproductive outcome in infertile females. However, a possible direct role of ketone bodies on sperm function has not been addressed so far. Methods Semen samples were obtained from 10 normozoospermic healthy donors attending the University Andrology Unit as participants in an infertility survey programme. The effect of β-HB on cell motility in vitro was evaluated on isolated spermatozoa according to their migratory activity in a swim-up selection procedure. The effect of β-HB on spermatozoa undergone to capacitation was also assessed. Results Two hours of exposure to β-HB, 1 mM or 4 mM, proved to be ineffective in modifying the motility of freshly ejaculated spermatozoa isolated according to the migratory activity in a swim-up procedure (all p values > 0.05). Differently, sperm maintenance in 4 mM β-HB after capacitation was associated with a significantly higher percentage of sperm cells with progressive motility compared to β-HB-lacking control (respectively, 67.6 ± 3.5% vs. 55.3 ± 6.5%, p = 0.0158). Succinyl-CoA transferase inhibitor abolished the effect on motility exerted by β-HB, underpinning a major role for this enzyme. Conclusion Our results suggest a possible physiological role for β-HB that could represent an energy metabolite in support of cell motility on capacitated spermatozoa right before encountering the oocyte." @default.
• W4361004076 created "2023-03-30" @default.
• W4361004076 creator A5005998619 @default.
• W4361004076 creator A5006015349 @default.
• W4361004076 creator A5014371364 @default.
• W4361004076 creator A5046789622 @default.
• W4361004076 creator A5046948951 @default.
• W4361004076 creator A5072833956 @default.
• W4361004076 creator A5082676383 @default.
• W4361004076 date "2023-03-27" @default.
• W4361004076 modified "2023-09-30" @default.
• W4361004076 title "Ketone Body β-Hydroxy-Butyrate Sustains Progressive Motility in Capacitated Human Spermatozoa: A Possible Role in Natural Fertility" @default.
• W4361004076 cites W1015286906 @default.
• W4361004076 cites W1998091904 @default.
• W4361004076 cites W2002082521 @default.
• W4361004076 cites W2026826434 @default.
• W4361004076 cites W2028808076 @default.
• W4361004076 cites W2037862209 @default.
• W4361004076 cites W2051712917 @default.
• W4361004076 cites W2086921193 @default.
• W4361004076 cites W2096912658 @default.
• W4361004076 cites W2114445980 @default.
• W4361004076 cites W2556344533 @default.
• W4361004076 cites W2783535973 @default.
• W4361004076 cites W2900877299 @default.
• W4361004076 cites W2911604922 @default.
• W4361004076 cites W2971649306 @default.
• W4361004076 cites W2994855180 @default.
• W4361004076 cites W2999812470 @default.
• W4361004076 cites W3031982810 @default.
• W4361004076 cites W3081380291 @default.
• W4361004076 cites W3082481249 @default.
• W4361004076 cites W3089062989 @default.
• W4361004076 cites W3126381753 @default.
• W4361004076 cites W3128915830 @default.
• W4361004076 cites W3134923972 @default.
• W4361004076 cites W3159928430 @default.
• W4361004076 cites W3162258278 @default.
• W4361004076 cites W3174270489 @default.
• W4361004076 cites W3194822211 @default.
• W4361004076 cites W3210767216 @default.
• W4361004076 cites W4210679587 @default.
• W4361004076 cites W4281255152 @default.
• W4361004076 cites W4291001966 @default.
• W4361004076 cites W4291465251 @default.
• W4361004076 cites W4293484247 @default.
• W4361004076 cites W4296365676 @default.
• W4361004076 cites W4296809290 @default.
• W4361004076 cites W4304806414 @default.
• W4361004076 cites W4309113526 @default.
• W4361004076 cites W4310588823 @default.
• W4361004076 cites W4310639253 @default.
• W4361004076 doi "https://doi.org/10.3390/nu15071622" @default.
• W4361004076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37049462" @default.
• W4361004076 hasPublicationYear "2023" @default.
• W4361004076 type Work @default.
• W4361004076 citedByCount "0" @default.
• W4361004076 crossrefType "journal-article" @default.
• W4361004076 hasAuthorship W4361004076A5005998619 @default.
• W4361004076 hasAuthorship W4361004076A5006015349 @default.
• W4361004076 hasAuthorship W4361004076A5014371364 @default.
• W4361004076 hasAuthorship W4361004076A5046789622 @default.
• W4361004076 hasAuthorship W4361004076A5046948951 @default.
• W4361004076 hasAuthorship W4361004076A5072833956 @default.
• W4361004076 hasAuthorship W4361004076A5082676383 @default.
• W4361004076 hasBestOaLocation W43610040761 @default.
• W4361004076 hasConcept C126322002 @default.
• W4361004076 hasConcept C134018914 @default.
• W4361004076 hasConcept C16685009 @default.
• W4361004076 hasConcept C185592680 @default.
• W4361004076 hasConcept C2776731943 @default.
• W4361004076 hasConcept C2777632594 @default.
• W4361004076 hasConcept C2777688143 @default.
• W4361004076 hasConcept C2778093475 @default.
• W4361004076 hasConcept C2779234561 @default.
• W4361004076 hasConcept C2780301668 @default.
• W4361004076 hasConcept C2781087480 @default.
• W4361004076 hasConcept C2908647359 @default.
• W4361004076 hasConcept C31532488 @default.
• W4361004076 hasConcept C518429986 @default.
• W4361004076 hasConcept C54355233 @default.
• W4361004076 hasConcept C555293320 @default.
• W4361004076 hasConcept C58207958 @default.
• W4361004076 hasConcept C62231903 @default.
• W4361004076 hasConcept C71924100 @default.
• W4361004076 hasConcept C86803240 @default.
• W4361004076 hasConcept C95444343 @default.
• W4361004076 hasConcept C99454951 @default.
• W4361004076 hasConceptScore W4361004076C126322002 @default.
• W4361004076 hasConceptScore W4361004076C134018914 @default.
• W4361004076 hasConceptScore W4361004076C16685009 @default.
• W4361004076 hasConceptScore W4361004076C185592680 @default.
• W4361004076 hasConceptScore W4361004076C2776731943 @default.
• W4361004076 hasConceptScore W4361004076C2777632594 @default.
• W4361004076 hasConceptScore W4361004076C2777688143 @default.
• W4361004076 hasConceptScore W4361004076C2778093475 @default.
• W4361004076 hasConceptScore W4361004076C2779234561 @default.
• W4361004076 hasConceptScore W4361004076C2780301668 @default.

• next