Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361006918> ?p ?o ?g. }
- W4361006918 endingPage "6265" @default.
- W4361006918 startingPage "6265" @default.
- W4361006918 abstract "Contraction in striated muscle is classically described as regulated by calcium-mediated structural changes in the actin-containing thin filaments, which release the binding sites for the interaction with myosin motors to produce force. In this view, myosin motors, arranged in the thick filaments, are basically always ready to interact with the thin filaments, which ultimately regulate the contraction. However, a new dual-filament activation paradigm is emerging, where both filaments must be activated to generate force. Growing evidence from the literature shows that the thick filament activation has a role on the striated muscle fine regulation, and its impairment is associated with severe pathologies. This review is focused on the proposed mechanical feedback that activates the inactive motors depending on the level of tension generated by the active ones, the so-called mechanosensing mechanism. Since the main muscle function is to generate mechanical work, the implications on muscle mechanics will be highlighted, showing: (i) how non-mechanical modulation of the thick filament activation influences the contraction, (ii) how the contraction influences the activation of the thick filament and (iii) how muscle, through the mechanical modulation of the thick filament activation, can regulate its own mechanics. This description highlights the crucial role of the emerging bi-directional feedback on muscle mechanical performance." @default.
- W4361006918 created "2023-03-30" @default.
- W4361006918 creator A5084106899 @default.
- W4361006918 date "2023-03-27" @default.
- W4361006918 modified "2023-09-30" @default.
- W4361006918 title "Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation" @default.
- W4361006918 cites W1542208611 @default.
- W4361006918 cites W1901823973 @default.
- W4361006918 cites W1940869608 @default.
- W4361006918 cites W1964517528 @default.
- W4361006918 cites W1967796829 @default.
- W4361006918 cites W1994999442 @default.
- W4361006918 cites W1997246410 @default.
- W4361006918 cites W2014719041 @default.
- W4361006918 cites W2017648450 @default.
- W4361006918 cites W2019251746 @default.
- W4361006918 cites W2025252646 @default.
- W4361006918 cites W2027396889 @default.
- W4361006918 cites W2033028307 @default.
- W4361006918 cites W2042048838 @default.
- W4361006918 cites W2042868213 @default.
- W4361006918 cites W2065298871 @default.
- W4361006918 cites W2069543061 @default.
- W4361006918 cites W2073327120 @default.
- W4361006918 cites W2074414105 @default.
- W4361006918 cites W2098548847 @default.
- W4361006918 cites W2107336909 @default.
- W4361006918 cites W2113092027 @default.
- W4361006918 cites W2121760447 @default.
- W4361006918 cites W2126468848 @default.
- W4361006918 cites W2131202031 @default.
- W4361006918 cites W2131248866 @default.
- W4361006918 cites W2138515609 @default.
- W4361006918 cites W2159551258 @default.
- W4361006918 cites W2161121324 @default.
- W4361006918 cites W2166627009 @default.
- W4361006918 cites W2171093275 @default.
- W4361006918 cites W2191896778 @default.
- W4361006918 cites W2266081913 @default.
- W4361006918 cites W2277697424 @default.
- W4361006918 cites W2283061987 @default.
- W4361006918 cites W2293449318 @default.
- W4361006918 cites W2348664324 @default.
- W4361006918 cites W2478655806 @default.
- W4361006918 cites W2519400429 @default.
- W4361006918 cites W2537119940 @default.
- W4361006918 cites W2544729146 @default.
- W4361006918 cites W2545141121 @default.
- W4361006918 cites W2589144612 @default.
- W4361006918 cites W2593328109 @default.
- W4361006918 cites W2613950069 @default.
- W4361006918 cites W2624048203 @default.
- W4361006918 cites W2679464329 @default.
- W4361006918 cites W2734486025 @default.
- W4361006918 cites W2734641374 @default.
- W4361006918 cites W2747734729 @default.
- W4361006918 cites W2751119444 @default.
- W4361006918 cites W2760597360 @default.
- W4361006918 cites W2779900292 @default.
- W4361006918 cites W2788670465 @default.
- W4361006918 cites W2805397392 @default.
- W4361006918 cites W2820660720 @default.
- W4361006918 cites W2883649026 @default.
- W4361006918 cites W2886773254 @default.
- W4361006918 cites W2889071211 @default.
- W4361006918 cites W2891626555 @default.
- W4361006918 cites W2898274867 @default.
- W4361006918 cites W2903210807 @default.
- W4361006918 cites W2911333943 @default.
- W4361006918 cites W2913061507 @default.
- W4361006918 cites W2913785049 @default.
- W4361006918 cites W2922964205 @default.
- W4361006918 cites W2942611143 @default.
- W4361006918 cites W2947170413 @default.
- W4361006918 cites W2950514677 @default.
- W4361006918 cites W2951957494 @default.
- W4361006918 cites W2952427101 @default.
- W4361006918 cites W2959338076 @default.
- W4361006918 cites W2959718672 @default.
- W4361006918 cites W2963242444 @default.
- W4361006918 cites W2963272368 @default.
- W4361006918 cites W2972835240 @default.
- W4361006918 cites W2976208503 @default.
- W4361006918 cites W3001201582 @default.
- W4361006918 cites W3013015010 @default.
- W4361006918 cites W3014347982 @default.
- W4361006918 cites W3027686835 @default.
- W4361006918 cites W3049143662 @default.
- W4361006918 cites W3080144454 @default.
- W4361006918 cites W3081778241 @default.
- W4361006918 cites W3087200528 @default.
- W4361006918 cites W3091060385 @default.
- W4361006918 cites W3109736363 @default.
- W4361006918 cites W3119072014 @default.
- W4361006918 cites W3121412916 @default.
- W4361006918 cites W3143807503 @default.
- W4361006918 cites W3154652692 @default.
- W4361006918 cites W3154816736 @default.