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• W4361006988 endingPage "6262" @default.
• W4361006988 startingPage "6262" @default.
• W4361006988 abstract "Pathogenic fungal diseases in crops are mediated by the release of effector proteins that facilitate infection. Characterising the structure of these fungal effectors is vital to understanding their virulence mechanisms and interactions with their hosts, which is crucial in the breeding of plant cultivars for disease resistance. Several effectors have been identified and validated experimentally; however, their lack of sequence conservation often impedes the identification and prediction of their structure using sequence similarity approaches. Structural similarity has, nonetheless, been observed within fungal effector protein families, creating interest in validating the use of computational methods to predict their tertiary structure from their sequence. We used Rosetta ab initio modelling to predict the structures of members of the ToxA-like and MAX effector families for which experimental structures are known to validate this method. An optimised approach was then used to predict the structures of phenotypically validated effectors lacking known structures. Rosetta was found to successfully predict the structure of fungal effectors in the ToxA-like and MAX families, as well as phenotypically validated but structurally unconfirmed effector sequences. Interestingly, potential new effector structural families were identified on the basis of comparisons with structural homologues and the identification of associated protein domains." @default.
• W4361006988 created "2023-03-30" @default.
• W4361006988 creator A5003016764 @default.
• W4361006988 creator A5020423413 @default.
• W4361006988 creator A5053211453 @default.
• W4361006988 creator A5063163513 @default.
• W4361006988 date "2023-03-26" @default.
• W4361006988 modified "2023-10-09" @default.
• W4361006988 title "Ab Initio Modelling of the Structure of ToxA-like and MAX Fungal Effector Proteins" @default.
• W4361006988 cites W1548178570 @default.
• W4361006988 cites W1706170868 @default.
• W4361006988 cites W195977463 @default.
• W4361006988 cites W1972104257 @default.
• W4361006988 cites W1986191025 @default.
• W4361006988 cites W1989228404 @default.
• W4361006988 cites W1990420785 @default.
• W4361006988 cites W1992192767 @default.
• W4361006988 cites W1993725043 @default.
• W4361006988 cites W2006192061 @default.
• W4361006988 cites W2013425283 @default.
• W4361006988 cites W2014776147 @default.
• W4361006988 cites W2017334980 @default.
• W4361006988 cites W2020426458 @default.
• W4361006988 cites W2031239680 @default.
• W4361006988 cites W2033746410 @default.
• W4361006988 cites W2052963427 @default.
• W4361006988 cites W2077770822 @default.
• W4361006988 cites W2078193456 @default.
• W4361006988 cites W2079684828 @default.
• W4361006988 cites W2085277871 @default.
• W4361006988 cites W2091194233 @default.
• W4361006988 cites W2094201044 @default.
• W4361006988 cites W2097632784 @default.
• W4361006988 cites W2098669490 @default.
• W4361006988 cites W2102245393 @default.
• W4361006988 cites W2104818961 @default.
• W4361006988 cites W2107276925 @default.
• W4361006988 cites W2115167726 @default.
• W4361006988 cites W2115540209 @default.
• W4361006988 cites W2115617617 @default.
• W4361006988 cites W2117020466 @default.
• W4361006988 cites W2119510132 @default.
• W4361006988 cites W2121627241 @default.
• W4361006988 cites W2124707779 @default.
• W4361006988 cites W2134233898 @default.
• W4361006988 cites W2137955461 @default.
• W4361006988 cites W2141783940 @default.
• W4361006988 cites W2145149019 @default.
• W4361006988 cites W2145258372 @default.
• W4361006988 cites W2148314524 @default.
• W4361006988 cites W2150467183 @default.
• W4361006988 cites W2153293076 @default.
• W4361006988 cites W2156767961 @default.
• W4361006988 cites W2157938277 @default.
• W4361006988 cites W2161151688 @default.
• W4361006988 cites W2167597940 @default.
• W4361006988 cites W2171559274 @default.
• W4361006988 cites W2179901684 @default.
• W4361006988 cites W2213426519 @default.
• W4361006988 cites W2255352529 @default.
• W4361006988 cites W2418223773 @default.
• W4361006988 cites W2444229884 @default.
• W4361006988 cites W2513707850 @default.
• W4361006988 cites W2529169778 @default.
• W4361006988 cites W2560844000 @default.
• W4361006988 cites W2574496196 @default.
• W4361006988 cites W2574528486 @default.
• W4361006988 cites W2577995238 @default.
• W4361006988 cites W2586311463 @default.
• W4361006988 cites W2598527232 @default.
• W4361006988 cites W2600626365 @default.
• W4361006988 cites W2606439133 @default.
• W4361006988 cites W2606882733 @default.
• W4361006988 cites W2609207099 @default.
• W4361006988 cites W2752786463 @default.
• W4361006988 cites W2755727916 @default.
• W4361006988 cites W2757160879 @default.
• W4361006988 cites W2787339353 @default.
• W4361006988 cites W2789543614 @default.
• W4361006988 cites W2794825320 @default.
• W4361006988 cites W2805522238 @default.
• W4361006988 cites W2814127638 @default.
• W4361006988 cites W2865801967 @default.
• W4361006988 cites W2896861545 @default.
• W4361006988 cites W2921939310 @default.
• W4361006988 cites W2954851300 @default.
• W4361006988 cites W2972316732 @default.
• W4361006988 cites W2973396428 @default.
• W4361006988 cites W2984761660 @default.
• W4361006988 cites W2985884608 @default.
• W4361006988 cites W3003287532 @default.
• W4361006988 cites W3022225908 @default.
• W4361006988 cites W3047943321 @default.
• W4361006988 cites W3106745904 @default.
• W4361006988 cites W3109588995 @default.
• W4361006988 cites W3144424074 @default.
• W4361006988 cites W3164850750 @default.
• W4361006988 cites W3177828909 @default.

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