Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361008020> ?p ?o ?g. }
- W4361008020 endingPage "6223" @default.
- W4361008020 startingPage "6223" @default.
- W4361008020 abstract "A number of purine arabinosides containing chiral amino acid amides at the C6 position of the purine were synthesized using a transglycosylation reaction with recombinant E. coli nucleoside phosphorylases. Arsenolysis of 2-chloropurine ribosides with chiral amino acid amides at C6 was used for the enzymatic synthesis, and the reaction equilibrium shifted towards the synthesis of arabinonucleosides. The synthesized nucleosides were shown to be resistant to the action of E. coli adenosine deaminase. The antiproliferative activity of the synthesized nucleosides was studied on human acute myeloid leukemia cell line U937. Among all the compounds, the serine derivative exhibited an activity level (IC50 = 16 μM) close to that of Nelarabine (IC50 = 3 μM) and was evaluated as active." @default.
- W4361008020 created "2023-03-30" @default.
- W4361008020 creator A5003790069 @default.
- W4361008020 creator A5017307817 @default.
- W4361008020 creator A5020550428 @default.
- W4361008020 creator A5023484851 @default.
- W4361008020 creator A5029595212 @default.
- W4361008020 creator A5039017409 @default.
- W4361008020 creator A5040839163 @default.
- W4361008020 creator A5040926273 @default.
- W4361008020 creator A5043318142 @default.
- W4361008020 creator A5052930403 @default.
- W4361008020 creator A5054283916 @default.
- W4361008020 creator A5070093604 @default.
- W4361008020 creator A5080133403 @default.
- W4361008020 creator A5081202680 @default.
- W4361008020 creator A5090160901 @default.
- W4361008020 date "2023-03-25" @default.
- W4361008020 modified "2023-09-27" @default.
- W4361008020 title "Enzymatic Synthesis of 2-Chloropurine Arabinonucleosides with Chiral Amino Acid Amides at the C6 Position and an Evaluation of Antiproliferative Activity In Vitro" @default.
- W4361008020 cites W1142125229 @default.
- W4361008020 cites W1669190037 @default.
- W4361008020 cites W195001029 @default.
- W4361008020 cites W1964812218 @default.
- W4361008020 cites W1965853467 @default.
- W4361008020 cites W1965982263 @default.
- W4361008020 cites W1990699846 @default.
- W4361008020 cites W1995883437 @default.
- W4361008020 cites W1997313325 @default.
- W4361008020 cites W2012837392 @default.
- W4361008020 cites W2015589957 @default.
- W4361008020 cites W2028531632 @default.
- W4361008020 cites W2036190683 @default.
- W4361008020 cites W2036672540 @default.
- W4361008020 cites W2040680298 @default.
- W4361008020 cites W2048669313 @default.
- W4361008020 cites W2060113628 @default.
- W4361008020 cites W2060933931 @default.
- W4361008020 cites W2076070109 @default.
- W4361008020 cites W2086492596 @default.
- W4361008020 cites W2089270482 @default.
- W4361008020 cites W2098072664 @default.
- W4361008020 cites W2100454960 @default.
- W4361008020 cites W2109370012 @default.
- W4361008020 cites W2121638813 @default.
- W4361008020 cites W2136689095 @default.
- W4361008020 cites W2154257363 @default.
- W4361008020 cites W2161018896 @default.
- W4361008020 cites W2325388429 @default.
- W4361008020 cites W2330490890 @default.
- W4361008020 cites W2497817158 @default.
- W4361008020 cites W2513228733 @default.
- W4361008020 cites W2525484033 @default.
- W4361008020 cites W2781763261 @default.
- W4361008020 cites W2783680124 @default.
- W4361008020 cites W2788126937 @default.
- W4361008020 cites W2904135722 @default.
- W4361008020 cites W2914321595 @default.
- W4361008020 cites W2952681893 @default.
- W4361008020 cites W3153292797 @default.
- W4361008020 cites W4230947829 @default.
- W4361008020 cites W4280512715 @default.
- W4361008020 cites W4298039886 @default.
- W4361008020 cites W9975565 @default.
- W4361008020 doi "https://doi.org/10.3390/ijms24076223" @default.
- W4361008020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37047197" @default.
- W4361008020 hasPublicationYear "2023" @default.
- W4361008020 type Work @default.
- W4361008020 citedByCount "1" @default.
- W4361008020 countsByYear W43610080202023 @default.
- W4361008020 crossrefType "journal-article" @default.
- W4361008020 hasAuthorship W4361008020A5003790069 @default.
- W4361008020 hasAuthorship W4361008020A5017307817 @default.
- W4361008020 hasAuthorship W4361008020A5020550428 @default.
- W4361008020 hasAuthorship W4361008020A5023484851 @default.
- W4361008020 hasAuthorship W4361008020A5029595212 @default.
- W4361008020 hasAuthorship W4361008020A5039017409 @default.
- W4361008020 hasAuthorship W4361008020A5040839163 @default.
- W4361008020 hasAuthorship W4361008020A5040926273 @default.
- W4361008020 hasAuthorship W4361008020A5043318142 @default.
- W4361008020 hasAuthorship W4361008020A5052930403 @default.
- W4361008020 hasAuthorship W4361008020A5054283916 @default.
- W4361008020 hasAuthorship W4361008020A5070093604 @default.
- W4361008020 hasAuthorship W4361008020A5080133403 @default.
- W4361008020 hasAuthorship W4361008020A5081202680 @default.
- W4361008020 hasAuthorship W4361008020A5090160901 @default.
- W4361008020 hasBestOaLocation W43610080201 @default.
- W4361008020 hasConcept C169586020 @default.
- W4361008020 hasConcept C181199279 @default.
- W4361008020 hasConcept C185592680 @default.
- W4361008020 hasConcept C202751555 @default.
- W4361008020 hasConcept C21951064 @default.
- W4361008020 hasConcept C2776414213 @default.
- W4361008020 hasConcept C2776476023 @default.
- W4361008020 hasConcept C2776543447 @default.
- W4361008020 hasConcept C2779321679 @default.
- W4361008020 hasConcept C34628245 @default.
- W4361008020 hasConcept C515207424 @default.