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- W4361009253 abstract "Pro-inflammatory mediators like IL-6 effectively mediated the majority of musculoskeletal disorders such rheumatoid arthritis (RA), osteoarthritis (OA), and tendinitis. Increased levels of IL-6 are found in the serum or synovial fluid of patients with these disorders, and these levels are correlated with the incidence and severity of the disease. IL-6 is crucial for the development of cartilage pathology, for example, by inducing a variety of pathways that are involved in the induction and spread of inflammation. The expression of anti-catabolic factors is similarly increased by IL-6, indicating a protective function. The differential impacts of IL-6 classic and trans-signaling may be the reason for this dual role of IL-6, which has so far remained poorly understood. In this article, the experimental and clinical data on the function of inhibiting IL-6 signaling in the development and progression of pathologies of the synovium, cartilage, and bones were thoroughly reviewed. By evaluating the IL-6 targeting approaches that are currently being considered in research and clinical practice, it may provide a glimpse into the future of these illnesses' treatment." @default.
- W4361009253 created "2023-03-30" @default.
- W4361009253 creator A5048623136 @default.
- W4361009253 creator A5051137498 @default.
- W4361009253 creator A5077977537 @default.
- W4361009253 date "2023-03-12" @default.
- W4361009253 modified "2023-10-17" @default.
- W4361009253 title "Targeting IL-6 Signaling Pathways for Musculoskeletal Disorders Treatment: Risks and Benefits" @default.
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- W4361009253 doi "https://doi.org/10.54133/ajms.v4i.101" @default.
- W4361009253 hasPublicationYear "2023" @default.
- W4361009253 type Work @default.