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- W4361011256 abstract "We demonstrate two synthetic single-cell systems that can be used to better understand how the acquisition of an orphan gene can affect complex phenotypes. The Arabidopsis orphan gene, Qua-Quine Starch (QQS) has been identified as a regulator of carbon (C) and nitrogen (N) partitioning across multiple plant species. QQS modulates this important biotechnological trait by replacing NF-YB (Nuclear Factor Y, subunit B) in its interaction with NF-YC. In this study, we expand on these prior findings by developing Chlamydomonas reinhardtii and Saccharomyces cerevisiae strains, to refactor the functional interactions between QQS and NF-Y subunits to affect modulations in C and N allocation. Expression of QQS in C. reinhardtii modulates C (i.e., starch) and N (i.e., protein) allocation by affecting interactions between NF-YC and NF-YB subunits. Studies in S. cerevisiae revealed similar functional interactions between QQS and the NF-YC homolog (HAP5), modulating C (i.e., glycogen) and N (i.e., protein) allocation. However, in S. cerevisiae both the NF-YA (HAP2) and NF-YB (HAP3) homologs appear to have redundant functions to enable QQS and HAP5 to affect C and N allocation. The genetically tractable systems that developed herein exhibit the plasticity to modulate highly complex phenotypes." @default.
- W4361011256 created "2023-03-30" @default.
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- W4361011256 date "2023-03-27" @default.
- W4361011256 modified "2023-10-05" @default.
- W4361011256 title "Single-cell genetic models to evaluate orphan gene function: The case of QQS regulating carbon and nitrogen allocation" @default.
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- W4361011256 doi "https://doi.org/10.3389/fpls.2023.1126139" @default.
- W4361011256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37051080" @default.
- W4361011256 hasPublicationYear "2023" @default.
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