Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361013013> ?p ?o ?g. }
- W4361013013 endingPage "17" @default.
- W4361013013 startingPage "1" @default.
- W4361013013 abstract "Telomeres are specialized, highly conserved DNA-protein complexes at the ends of linear eukaryotic chromosomes. Human telomeric DNA is composed of tandem repeats of the sequence 5′-(TTAGGG)n-3′ and is complexed with sequence-specific DNA binding proteins, forming a distinctive “cap” at the ends of chromosomes. Telomeres serve to distinguish the end of the chromosome from an internal DNA break and the cellular DNA repair machinery, thereby protecting chromosomes from deleterious end-to-end fusions. Telomeres are dynamic structures, shortening during each cycle of DNA replication and cell division. In the absence of a compensatory telomere-lengthening mechanism, progressive telomere shortening imposes limits on the proliferative capacity of cells, contributing to organismal aging. Cells with unlimited proliferative capacity – notably stem cells and cancer cells – must activate a telomere lengthening mechanism. There are two such mechanisms known in humans: the ribonucleoprotein enzyme telomerase (discussed in Chap. Telomerase) and the recombination-based mechanism Alternative Lengthening of Telomeres. Most human somatic cells do not maintain their telomeres and undergo telomere shortening. In contrast, dysregulated telomere maintenance is a universal property of cancer cells. Understanding the biology and dynamics of telomeres has far-reaching implications for human health and medicine." @default.
- W4361013013 created "2023-03-30" @default.
- W4361013013 creator A5056700216 @default.
- W4361013013 creator A5058683661 @default.
- W4361013013 date "2023-01-01" @default.
- W4361013013 modified "2023-09-29" @default.
- W4361013013 title "Telomeres: Structure and Function" @default.
- W4361013013 cites W1497143641 @default.
- W4361013013 cites W1523125680 @default.
- W4361013013 cites W1543500873 @default.
- W4361013013 cites W1562677361 @default.
- W4361013013 cites W1600373583 @default.
- W4361013013 cites W1871424174 @default.
- W4361013013 cites W1927581912 @default.
- W4361013013 cites W1963869208 @default.
- W4361013013 cites W1965019589 @default.
- W4361013013 cites W1966346464 @default.
- W4361013013 cites W1970501424 @default.
- W4361013013 cites W1972655555 @default.
- W4361013013 cites W1977871027 @default.
- W4361013013 cites W1979609161 @default.
- W4361013013 cites W1982199027 @default.
- W4361013013 cites W1983673827 @default.
- W4361013013 cites W1985641439 @default.
- W4361013013 cites W1985910710 @default.
- W4361013013 cites W1986009297 @default.
- W4361013013 cites W1988399759 @default.
- W4361013013 cites W1998371493 @default.
- W4361013013 cites W1999054014 @default.
- W4361013013 cites W2000971601 @default.
- W4361013013 cites W2002255627 @default.
- W4361013013 cites W2006496261 @default.
- W4361013013 cites W2007433513 @default.
- W4361013013 cites W2010882280 @default.
- W4361013013 cites W2013073993 @default.
- W4361013013 cites W2021061167 @default.
- W4361013013 cites W2022507419 @default.
- W4361013013 cites W2028147887 @default.
- W4361013013 cites W2028320710 @default.
- W4361013013 cites W2030976397 @default.
- W4361013013 cites W2032407757 @default.
- W4361013013 cites W2034200215 @default.
- W4361013013 cites W2035389897 @default.
- W4361013013 cites W2044430178 @default.
- W4361013013 cites W2062671651 @default.
- W4361013013 cites W2072744580 @default.
- W4361013013 cites W2075977300 @default.
- W4361013013 cites W2080032853 @default.
- W4361013013 cites W2084575716 @default.
- W4361013013 cites W2086992094 @default.
- W4361013013 cites W2091876286 @default.
- W4361013013 cites W2106996266 @default.
- W4361013013 cites W2114697209 @default.
- W4361013013 cites W2124139300 @default.
- W4361013013 cites W2136986586 @default.
- W4361013013 cites W2141288561 @default.
- W4361013013 cites W2141444502 @default.
- W4361013013 cites W2154468838 @default.
- W4361013013 cites W2155773930 @default.
- W4361013013 cites W2156857490 @default.
- W4361013013 cites W2161232591 @default.
- W4361013013 cites W2164580633 @default.
- W4361013013 cites W2177542975 @default.
- W4361013013 cites W2334974904 @default.
- W4361013013 cites W2398118418 @default.
- W4361013013 cites W2745330422 @default.
- W4361013013 cites W2749713157 @default.
- W4361013013 cites W2765080185 @default.
- W4361013013 cites W2767611854 @default.
- W4361013013 cites W2790795270 @default.
- W4361013013 cites W2795121593 @default.
- W4361013013 cites W2802026635 @default.
- W4361013013 cites W2892224724 @default.
- W4361013013 cites W2913360660 @default.
- W4361013013 cites W2914077213 @default.
- W4361013013 cites W2914940244 @default.
- W4361013013 cites W2970657071 @default.
- W4361013013 cites W2974390064 @default.
- W4361013013 cites W2987058388 @default.
- W4361013013 cites W3006715535 @default.
- W4361013013 cites W3014612309 @default.
- W4361013013 cites W3048864866 @default.
- W4361013013 cites W3127394761 @default.
- W4361013013 cites W3135742164 @default.
- W4361013013 cites W3151668984 @default.
- W4361013013 cites W4280627303 @default.
- W4361013013 cites W4283723741 @default.
- W4361013013 cites W4295763006 @default.
- W4361013013 cites W803636485 @default.
- W4361013013 doi "https://doi.org/10.1007/978-981-16-1313-5_104-1" @default.
- W4361013013 hasPublicationYear "2023" @default.
- W4361013013 type Work @default.
- W4361013013 citedByCount "0" @default.
- W4361013013 crossrefType "book-chapter" @default.
- W4361013013 hasAuthorship W4361013013A5056700216 @default.
- W4361013013 hasAuthorship W4361013013A5058683661 @default.
- W4361013013 hasConcept C104317684 @default.
- W4361013013 hasConcept C125593758 @default.