FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361018498> ?p ?o ?g. }

• W4361018498 endingPage "299" @default.
• W4361018498 startingPage "291" @default.
• W4361018498 abstract "For a long time, metformin has been the first-line treatment for glycemic control in type 2 diabetes; however, the results of recent cardiovascular outcome trials of sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide 1 receptor agonists have caused many to question metformin's position in the guidelines. Although there are several plausible mechanisms by which metformin might have beneficial cardiovascular effects, for example, its anti-inflammatory effects and metabolic properties, and numerous observational data suggesting improved cardiovascular outcomes with metformin use, the main randomized clinical trial data for metformin was published over 20 years ago. Nevertheless, the overwhelming majority of participants in contemporary type 2 diabetes trials were prescribed metformin.In this review, we will summarize the potential mechanisms of cardiovascular benefit with metformin, before discussing clinical data in individuals with or without diabetes.Metformin may have some cardiovascular benefit in patients with and without diabetes, however the majority of clinical trials were small and are before the use SGLT2 inhibitors and GLP1-RAs. Larger contemporary randomized trials, with metformin evaluating its cardiovascular benefit are warranted." @default.
• W4361018498 created "2023-03-30" @default.
• W4361018498 creator A5027852973 @default.
• W4361018498 creator A5045547434 @default.
• W4361018498 creator A5058269381 @default.
• W4361018498 creator A5068204697 @default.
• W4361018498 creator A5073074221 @default.
• W4361018498 date "2023-04-03" @default.
• W4361018498 modified "2023-09-25" @default.
• W4361018498 title "Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease" @default.
• W4361018498 cites W1538751400 @default.
• W4361018498 cites W1824516519 @default.
• W4361018498 cites W1889956147 @default.
• W4361018498 cites W1974882515 @default.
• W4361018498 cites W1983692570 @default.
• W4361018498 cites W1986005367 @default.
• W4361018498 cites W2017222660 @default.
• W4361018498 cites W2031565266 @default.
• W4361018498 cites W2035353547 @default.
• W4361018498 cites W2036555858 @default.
• W4361018498 cites W2050160827 @default.
• W4361018498 cites W2101745628 @default.
• W4361018498 cites W2103308668 @default.
• W4361018498 cites W2105665055 @default.
• W4361018498 cites W2112904969 @default.
• W4361018498 cites W2123424236 @default.
• W4361018498 cites W2127322520 @default.
• W4361018498 cites W2140307562 @default.
• W4361018498 cites W2141199290 @default.
• W4361018498 cites W2150052417 @default.
• W4361018498 cites W2150959326 @default.
• W4361018498 cites W2156029342 @default.
• W4361018498 cites W2157870057 @default.
• W4361018498 cites W2158987422 @default.
• W4361018498 cites W2168731601 @default.
• W4361018498 cites W2188846692 @default.
• W4361018498 cites W2192805965 @default.
• W4361018498 cites W2205704111 @default.
• W4361018498 cites W2473725818 @default.
• W4361018498 cites W2484644533 @default.
• W4361018498 cites W2516762108 @default.
• W4361018498 cites W2588127161 @default.
• W4361018498 cites W2603491649 @default.
• W4361018498 cites W2619552711 @default.
• W4361018498 cites W2624031057 @default.
• W4361018498 cites W2740802742 @default.
• W4361018498 cites W2743010525 @default.
• W4361018498 cites W2748400555 @default.
• W4361018498 cites W2790119520 @default.
• W4361018498 cites W2791683058 @default.
• W4361018498 cites W2793073430 @default.
• W4361018498 cites W2794128897 @default.
• W4361018498 cites W2887891928 @default.
• W4361018498 cites W2895533920 @default.
• W4361018498 cites W2916248238 @default.
• W4361018498 cites W2918157477 @default.
• W4361018498 cites W2922422823 @default.
• W4361018498 cites W2931823730 @default.
• W4361018498 cites W2937481281 @default.
• W4361018498 cites W2966851967 @default.
• W4361018498 cites W2986700515 @default.
• W4361018498 cites W2993174630 @default.
• W4361018498 cites W2995448284 @default.
• W4361018498 cites W3000694081 @default.
• W4361018498 cites W3004050106 @default.
• W4361018498 cites W3014161033 @default.
• W4361018498 cites W3047245556 @default.
• W4361018498 cites W3047938855 @default.
• W4361018498 cites W3081761942 @default.
• W4361018498 cites W3083297478 @default.
• W4361018498 cites W3085610072 @default.
• W4361018498 cites W3092141906 @default.
• W4361018498 cites W3092379111 @default.
• W4361018498 cites W3128709333 @default.
• W4361018498 cites W3145790711 @default.
• W4361018498 cites W3177042347 @default.
• W4361018498 cites W3185255196 @default.
• W4361018498 cites W3195404919 @default.
• W4361018498 cites W3196269403 @default.
• W4361018498 cites W3216937933 @default.
• W4361018498 cites W4200071776 @default.
• W4361018498 cites W4200417285 @default.
• W4361018498 cites W4210847638 @default.
• W4361018498 cites W4226003868 @default.
• W4361018498 cites W4246340431 @default.
• W4361018498 cites W4251467990 @default.
• W4361018498 cites W4281298651 @default.
• W4361018498 cites W4285792404 @default.
• W4361018498 cites W4288702913 @default.
• W4361018498 cites W4295128590 @default.
• W4361018498 cites W4296802076 @default.
• W4361018498 cites W4297021616 @default.
• W4361018498 cites W4304196136 @default.
• W4361018498 cites W772368145 @default.
• W4361018498 doi "https://doi.org/10.1080/13543784.2023.2196010" @default.
• W4361018498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36972373" @default.
• W4361018498 hasPublicationYear "2023" @default.
• W4361018498 type Work @default.

• next