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- W4361023786 abstract "Cammelia oleifera C.Abel (C. oleifera), a characteristic tropical economic crop, which is widely cultivated in Southern China. The fruit shells are a main by-product in the C. oleifera industry without high-value utilization. This work optimized the ultrasound-microwave synergistic extraction (UMSE) process of C. oleifera shells crude polyphenols (CSCP). The impacts of C. oleifera shells pure polyphenols (CSPP) on the advanced glycation end-products (AGEs) accumulation and AGEs-triggered inflammation were assessed. The results showed that the highest yield of CSCP reached 125.85 ± 5.34 mg extract/g dry shells under the optimum condition. Furthermore, CSPP exhibited intense anti-glycation action by scavenging free radicals and glycated intermediates, chelating transition metals, attenuating molecular aggregation, and conformational modification of BSA. Moreover, CSPP was found to dose-dependently block the AGEs-induced secretions of pro-inflammatory cytokines by inhibiting the downstream iNOS and COX-2 related MAPK/NF-κB pathway. These findings indicated that C. oleifera shells polyphenols could be a functional ingredient for preventing AGEs production and AGEs-induced inflammation." @default.
- W4361023786 created "2023-03-30" @default.
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- W4361023786 date "2023-07-01" @default.
- W4361023786 modified "2023-09-27" @default.
- W4361023786 title "Camellia oleifera shells polyphenols inhibit advanced glycation end-products (AGEs) formation and AGEs-induced inflammatory response in RAW264.7 macrophages" @default.
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- W4361023786 doi "https://doi.org/10.1016/j.indcrop.2023.116589" @default.
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