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• W4361026897 endingPage "114601" @default.
• W4361026897 startingPage "114601" @default.
• W4361026897 abstract "Oncogenesis and the development of tumors affect metabolism throughout the body. Metabolic reprogramming (also known as metabolic remodeling) is a feature of malignant tumors that is driven by oncogenic changes in the cancer cells themselves as well as by cytokines in the tumor microenvironment. These include endothelial cells, matrix fibroblasts, immune cells, and malignant tumor cells. The heterogeneity of mutant clones is affected by the actions of other cells in the tumor and by metabolites and cytokines in the microenvironment. Metabolism can also influence immune cell phenotype and function. Metabolic reprogramming of cancer cells is the result of a convergence of both internal and external signals. The basal metabolic state is maintained by internal signaling, while external signaling fine-tunes the metabolic process based on metabolite availability and cellular needs. This paper reviews the metabolic characteristics of gastric cancer, focusing on the intrinsic and extrinsic mechanisms that drive cancer metabolism in the tumor microenvironment, and interactions between tumor cell metabolic changes and microenvironment metabolic changes. This information will be helpful for the individualized metabolic treatment of gastric cancers." @default.
• W4361026897 created "2023-03-30" @default.
• W4361026897 creator A5016078829 @default.
• W4361026897 creator A5040694305 @default.
• W4361026897 creator A5051363890 @default.
• W4361026897 creator A5064528387 @default.
• W4361026897 date "2023-06-01" @default.
• W4361026897 modified "2023-10-06" @default.
• W4361026897 title "Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities" @default.
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