Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361190264> ?p ?o ?g. }
- W4361190264 abstract "The development of materials that can more efficiently administer antimicrobial agents in a controlled manner is urgently needed due to the rise in microbial resistance to traditional antibiotics. While new classes of antibiotics are developed and put into widespread usage, existing, inexpensive compounds can be repurposed to fight bacterial infections. Here, we present the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials with physisorbed rafoxanide (RFX), a commonly used salicylanilide anthelmintic, and anchored Cu(II) ions that exhibit enhanced antimicrobial efficacy against the pathogenic bacterium Staphylococcus aureus. The synthesized nanomaterials are structurally characterized by a combination of physicochemical, thermal, and optical methods. Additionally, release studies are carried out in vitro to determine the effects of pH and the synthetic sequence used to produce the materials on Cu(II) ion release. Our results indicate that SBA-15 mesoporous silica nanocarriers loaded with Cu(II) and RFX exhibit 10 times as much bactericidal action against wild-type S. aureus as the nanocarrier loaded with only RFX. Furthermore, the synthetic sequence used to produce the nanomaterials could significantly affect (enhance) their bactericidal efficacy." @default.
- W4361190264 created "2023-03-31" @default.
- W4361190264 creator A5002631338 @default.
- W4361190264 creator A5004226797 @default.
- W4361190264 creator A5014740952 @default.
- W4361190264 creator A5018133494 @default.
- W4361190264 creator A5055481667 @default.
- W4361190264 creator A5067036957 @default.
- W4361190264 creator A5078821249 @default.
- W4361190264 date "2023-03-28" @default.
- W4361190264 modified "2023-09-23" @default.
- W4361190264 title "Repurposing Anthelmintics: Rafoxanide- and Copper-Functionalized SBA-15 Carriers against Methicillin-Resistant <i>Staphylococcus aureus</i>" @default.
- W4361190264 cites W1810511947 @default.
- W4361190264 cites W1841234159 @default.
- W4361190264 cites W1971842521 @default.
- W4361190264 cites W1979201029 @default.
- W4361190264 cites W1987379791 @default.
- W4361190264 cites W1991471402 @default.
- W4361190264 cites W1995041236 @default.
- W4361190264 cites W2007969411 @default.
- W4361190264 cites W2014332065 @default.
- W4361190264 cites W2016351987 @default.
- W4361190264 cites W2018369686 @default.
- W4361190264 cites W2030197044 @default.
- W4361190264 cites W2046811077 @default.
- W4361190264 cites W2082657579 @default.
- W4361190264 cites W2096211780 @default.
- W4361190264 cites W2097951502 @default.
- W4361190264 cites W2111604015 @default.
- W4361190264 cites W2112784401 @default.
- W4361190264 cites W2137260452 @default.
- W4361190264 cites W2137354818 @default.
- W4361190264 cites W2141218575 @default.
- W4361190264 cites W2142758007 @default.
- W4361190264 cites W2143575872 @default.
- W4361190264 cites W2168613100 @default.
- W4361190264 cites W2168696947 @default.
- W4361190264 cites W2189116376 @default.
- W4361190264 cites W2305704688 @default.
- W4361190264 cites W2320732045 @default.
- W4361190264 cites W2323122511 @default.
- W4361190264 cites W2403202013 @default.
- W4361190264 cites W2520472295 @default.
- W4361190264 cites W2551983946 @default.
- W4361190264 cites W2590618747 @default.
- W4361190264 cites W2591378369 @default.
- W4361190264 cites W2597381530 @default.
- W4361190264 cites W2598359550 @default.
- W4361190264 cites W2615157865 @default.
- W4361190264 cites W2739776038 @default.
- W4361190264 cites W2751348861 @default.
- W4361190264 cites W2759319717 @default.
- W4361190264 cites W2797757758 @default.
- W4361190264 cites W2894396313 @default.
- W4361190264 cites W2898376995 @default.
- W4361190264 cites W2898955132 @default.
- W4361190264 cites W2901096651 @default.
- W4361190264 cites W2906369916 @default.
- W4361190264 cites W2906591584 @default.
- W4361190264 cites W2913573831 @default.
- W4361190264 cites W2920302906 @default.
- W4361190264 cites W2938748142 @default.
- W4361190264 cites W2941816803 @default.
- W4361190264 cites W2971222818 @default.
- W4361190264 cites W2984769547 @default.
- W4361190264 cites W2998567579 @default.
- W4361190264 cites W3000678109 @default.
- W4361190264 cites W3004122457 @default.
- W4361190264 cites W3014667439 @default.
- W4361190264 cites W3030471300 @default.
- W4361190264 cites W3034201112 @default.
- W4361190264 cites W3092058422 @default.
- W4361190264 cites W3153233780 @default.
- W4361190264 cites W3183327814 @default.
- W4361190264 cites W3197071928 @default.
- W4361190264 cites W3202380741 @default.
- W4361190264 cites W3210890336 @default.
- W4361190264 cites W3211323050 @default.
- W4361190264 cites W4210697235 @default.
- W4361190264 cites W4237549879 @default.
- W4361190264 doi "https://doi.org/10.1021/acsami.2c19899" @default.
- W4361190264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36975176" @default.
- W4361190264 hasPublicationYear "2023" @default.
- W4361190264 type Work @default.
- W4361190264 citedByCount "0" @default.
- W4361190264 crossrefType "journal-article" @default.
- W4361190264 hasAuthorship W4361190264A5002631338 @default.
- W4361190264 hasAuthorship W4361190264A5004226797 @default.
- W4361190264 hasAuthorship W4361190264A5014740952 @default.
- W4361190264 hasAuthorship W4361190264A5018133494 @default.
- W4361190264 hasAuthorship W4361190264A5055481667 @default.
- W4361190264 hasAuthorship W4361190264A5067036957 @default.
- W4361190264 hasAuthorship W4361190264A5078821249 @default.
- W4361190264 hasConcept C161790260 @default.
- W4361190264 hasConcept C171250308 @default.
- W4361190264 hasConcept C178790620 @default.
- W4361190264 hasConcept C18150654 @default.
- W4361190264 hasConcept C185592680 @default.
- W4361190264 hasConcept C192562407 @default.
- W4361190264 hasConcept C21951064 @default.