Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361191155> ?p ?o ?g. }
- W4361191155 endingPage "5119" @default.
- W4361191155 startingPage "5094" @default.
- W4361191155 abstract "Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and exhibit limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illness therapy. GBM biomarkers have been investigated for their potential utility in prognostic stratification, driving the development of targeted therapy and customizing therapeutic treatment. Due to the availability of a specific EGFRvIII mutational variation with a clear function in glioma-genesis, recent research suggests that EGFR has the potential to be a prognostic factor in GBM, while others have shown no clinical link between EGFR and survival. The pre-existing pharmaceutical lapatinib (PubChem ID: 208,908) with a higher affinity score is used for virtual screening. As a result, the current study revealed a newly screened chemical (PubChem CID: 59,671,768) with a higher affinity than the previously known molecule. When the two compounds are compared, the former has the lowest re-rank score. The time-resolved features of a virtually screened chemical and an established compound were investigated using molecular dynamics simulation. Both compounds are equivalent, according to the ADMET study. This report implies that the virtual screened chemical could be a promising Glioblastoma therapy." @default.
- W4361191155 created "2023-03-31" @default.
- W4361191155 creator A5005935180 @default.
- W4361191155 creator A5015958143 @default.
- W4361191155 creator A5018119690 @default.
- W4361191155 creator A5023674386 @default.
- W4361191155 creator A5028507292 @default.
- W4361191155 creator A5029236328 @default.
- W4361191155 creator A5035517514 @default.
- W4361191155 creator A5039698974 @default.
- W4361191155 creator A5048611771 @default.
- W4361191155 creator A5051797139 @default.
- W4361191155 creator A5054825291 @default.
- W4361191155 creator A5057396409 @default.
- W4361191155 creator A5060700478 @default.
- W4361191155 creator A5064744326 @default.
- W4361191155 creator A5071200904 @default.
- W4361191155 creator A5079032250 @default.
- W4361191155 creator A5084244430 @default.
- W4361191155 date "2023-03-28" @default.
- W4361191155 modified "2023-09-30" @default.
- W4361191155 title "Structure-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation of EGFR for the Clinical Treatment of Glioblastoma" @default.
- W4361191155 cites W1553254670 @default.
- W4361191155 cites W1934617888 @default.
- W4361191155 cites W1952429608 @default.
- W4361191155 cites W1967759145 @default.
- W4361191155 cites W1970174108 @default.
- W4361191155 cites W1992064692 @default.
- W4361191155 cites W1993496827 @default.
- W4361191155 cites W2000078674 @default.
- W4361191155 cites W2000387332 @default.
- W4361191155 cites W2007920048 @default.
- W4361191155 cites W2008011004 @default.
- W4361191155 cites W2011179500 @default.
- W4361191155 cites W2015325092 @default.
- W4361191155 cites W2026493967 @default.
- W4361191155 cites W2026761135 @default.
- W4361191155 cites W2036926586 @default.
- W4361191155 cites W2037466740 @default.
- W4361191155 cites W2037483912 @default.
- W4361191155 cites W2039769495 @default.
- W4361191155 cites W2046189043 @default.
- W4361191155 cites W2054727624 @default.
- W4361191155 cites W2056681493 @default.
- W4361191155 cites W2059720052 @default.
- W4361191155 cites W2061701210 @default.
- W4361191155 cites W2078417687 @default.
- W4361191155 cites W2084817237 @default.
- W4361191155 cites W2085046739 @default.
- W4361191155 cites W2090001322 @default.
- W4361191155 cites W2093019970 @default.
- W4361191155 cites W2095032529 @default.
- W4361191155 cites W2102000647 @default.
- W4361191155 cites W2108535530 @default.
- W4361191155 cites W2113176971 @default.
- W4361191155 cites W2117139777 @default.
- W4361191155 cites W2122919112 @default.
- W4361191155 cites W2124254332 @default.
- W4361191155 cites W2134871530 @default.
- W4361191155 cites W2143580838 @default.
- W4361191155 cites W2143897427 @default.
- W4361191155 cites W2150200928 @default.
- W4361191155 cites W2152064969 @default.
- W4361191155 cites W2153382082 @default.
- W4361191155 cites W2154889628 @default.
- W4361191155 cites W2161008794 @default.
- W4361191155 cites W2163649178 @default.
- W4361191155 cites W2165469857 @default.
- W4361191155 cites W2270910539 @default.
- W4361191155 cites W2345475763 @default.
- W4361191155 cites W2350344411 @default.
- W4361191155 cites W2398883411 @default.
- W4361191155 cites W2403800803 @default.
- W4361191155 cites W2424491200 @default.
- W4361191155 cites W2460971110 @default.
- W4361191155 cites W2553447691 @default.
- W4361191155 cites W2560698422 @default.
- W4361191155 cites W2593436234 @default.
- W4361191155 cites W2612691429 @default.
- W4361191155 cites W2621082482 @default.
- W4361191155 cites W2747311978 @default.
- W4361191155 cites W2757955078 @default.
- W4361191155 cites W2766250556 @default.
- W4361191155 cites W2788268344 @default.
- W4361191155 cites W2794558853 @default.
- W4361191155 cites W2795151481 @default.
- W4361191155 cites W2888936354 @default.
- W4361191155 cites W2901524314 @default.
- W4361191155 cites W2902954978 @default.
- W4361191155 cites W2905505062 @default.
- W4361191155 cites W2929859766 @default.
- W4361191155 cites W2941427054 @default.
- W4361191155 cites W2952332644 @default.
- W4361191155 cites W2953462635 @default.
- W4361191155 cites W2954403888 @default.
- W4361191155 cites W2955111598 @default.
- W4361191155 cites W2955644682 @default.
- W4361191155 cites W2969747342 @default.