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- W4361200133 abstract "<p>Corresponding signal of previous reported autoantibodies for early lung cancer detection were evaluated in our study cohort with both HuProtTM protein microarray (detail data not shown) and peptide array. All peptides were aligned to 10 proteins using blastp method, 246 peptides were mapped under the set of e-value of 1 and identity of 90. Accumulated peptide signal was set as autoantibody signal of corresponding antigen protein. Nine autoantibodies had effective testing value in HuprotTM. a.t test P value of autoantibodies signals for Early-LUAD versus NHC from peptide array and HuProtTM detection respectively. Two autoantibodies from peptide array and 2 autoantibodies from HuProtTM showed higher signal in Early-LUAD group under P <0.05. Five autoantibodies from peptide array and 2 autoantibodies from HuProtTM showed higher signal in Early-LUAD group under P < 0.1.b.Volcano plot of peptides signals corresponding to 10 autoantigens. X-axis represents the log10 of the fold change, y-axis represents -log10 (P adjust) for Early-LUAD versus NHC. Significantly up-regulated and down-regulated peptides in Early-LUAD group are shown in light red and blue. Two hundred and forty-six peptides mapped to the 10 autoantibodies were shown in green, and 8 significantly upregulated peptides in Early-LUAD shown in green cross. No intersection between the green mapped signals and the peptides used for classifier model (dark red).</p>" @default.
- W4361200133 created "2023-03-31" @default.
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- W4361200133 date "2023-03-29" @default.
- W4361200133 modified "2023-10-16" @default.
- W4361200133 title "Figure S2 from High-Throughput Peptide Arrays Identify Potential Diagnostic Autoantibody Signatures in Early-Stage Lung Adenocarcinoma" @default.
- W4361200133 doi "https://doi.org/10.1158/1055-9965.22354207" @default.
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