FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361204667> ?p ?o ?g. }

• W4361204667 endingPage "131293" @default.
• W4361204667 startingPage "131293" @default.
• W4361204667 abstract "Research on the negative impacts of PM2.5 have been focused on lung, brain, immune, and metabolism-related diseases. However, little is known about the mechanism underlying the effects of PM2.5 on the modulation of hematopoietic stem cell (HSC) fate. Maturation of the hematopoietic system and differentiation of hematopoietic stem progenitor cells (HSPCs) occurs soon after birth when infants are susceptible to external stresses. We investigated how exposure to atmospherically relevant artificial particulate matter of diameter < 2.5 µm (termed, PM2.5) affects HSPCs in newborns. The lungs of newborn mice exposed to PM2.5 exhibited higher levels of oxidative stress and inflammasome activation, which continued during aging. PM2.5 also stimulated oxidative stress and inflammasome activation in bone marrow (BM). PM2.5-exposed infant mice at 12 months but not at 6 months displayed progressive senescence of HSCs accompanied by preferential impairment of the BM microenvironment with age-related phenotypes, as evidenced by colony-forming assay and serial transplantation and animal survival experiments. Further, PM2.5-exposed middle-aged mice did not exhibit radioprotective potential. Collectively, exposure of newborns to PM2.5 causes progressive senescence of HSCs. These findings revealed a novel mechanism by which PM2.5 affects the fate of HSCs, highlighting the crucial role of early life exposure to air pollution in determining human health outcomes." @default.
• W4361204667 created "2023-03-31" @default.
• W4361204667 creator A5027793412 @default.
• W4361204667 creator A5044518854 @default.
• W4361204667 creator A5055939739 @default.
• W4361204667 creator A5058409034 @default.
• W4361204667 creator A5059865096 @default.
• W4361204667 date "2023-06-01" @default.
• W4361204667 modified "2023-09-30" @default.
• W4361204667 title "Exposure of newborns to atmospherically relevant artificial particulate matter induces hematopoietic stem cell senescence" @default.
• W4361204667 cites W1640993000 @default.
• W4361204667 cites W1665091387 @default.
• W4361204667 cites W1792070163 @default.
• W4361204667 cites W1925093782 @default.
• W4361204667 cites W1952464171 @default.
• W4361204667 cites W1956607899 @default.
• W4361204667 cites W1978683461 @default.
• W4361204667 cites W1987628377 @default.
• W4361204667 cites W1992635510 @default.
• W4361204667 cites W1995889511 @default.
• W4361204667 cites W1998974001 @default.
• W4361204667 cites W2020383780 @default.
• W4361204667 cites W2023355455 @default.
• W4361204667 cites W2026212073 @default.
• W4361204667 cites W2027610354 @default.
• W4361204667 cites W2028769116 @default.
• W4361204667 cites W2040113717 @default.
• W4361204667 cites W2053889157 @default.
• W4361204667 cites W2073692681 @default.
• W4361204667 cites W2077330278 @default.
• W4361204667 cites W2083441060 @default.
• W4361204667 cites W2084156847 @default.
• W4361204667 cites W2094069370 @default.
• W4361204667 cites W2101584854 @default.
• W4361204667 cites W2102501205 @default.
• W4361204667 cites W2114514472 @default.
• W4361204667 cites W2126138300 @default.
• W4361204667 cites W2129741340 @default.
• W4361204667 cites W2129935236 @default.
• W4361204667 cites W2134100561 @default.
• W4361204667 cites W2136263534 @default.
• W4361204667 cites W2141970008 @default.
• W4361204667 cites W2142120156 @default.
• W4361204667 cites W2154589633 @default.
• W4361204667 cites W2158822760 @default.
• W4361204667 cites W2267931422 @default.
• W4361204667 cites W2296385664 @default.
• W4361204667 cites W2436589948 @default.
• W4361204667 cites W2496826203 @default.
• W4361204667 cites W2514973363 @default.
• W4361204667 cites W2531799707 @default.
• W4361204667 cites W2606569879 @default.
• W4361204667 cites W2943293743 @default.
• W4361204667 cites W2990240899 @default.
• W4361204667 cites W3110398707 @default.
• W4361204667 cites W3161832189 @default.
• W4361204667 cites W3186325341 @default.
• W4361204667 cites W4200091451 @default.
• W4361204667 cites W4289545008 @default.
• W4361204667 cites W4318309524 @default.
• W4361204667 doi "https://doi.org/10.1016/j.jhazmat.2023.131293" @default.
• W4361204667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37002998" @default.
• W4361204667 hasPublicationYear "2023" @default.
• W4361204667 type Work @default.
• W4361204667 citedByCount "1" @default.
• W4361204667 crossrefType "journal-article" @default.
• W4361204667 hasAuthorship W4361204667A5027793412 @default.
• W4361204667 hasAuthorship W4361204667A5044518854 @default.
• W4361204667 hasAuthorship W4361204667A5055939739 @default.
• W4361204667 hasAuthorship W4361204667A5058409034 @default.
• W4361204667 hasAuthorship W4361204667A5059865096 @default.
• W4361204667 hasBestOaLocation W43612046671 @default.
• W4361204667 hasConcept C109159458 @default.
• W4361204667 hasConcept C134018914 @default.
• W4361204667 hasConcept C201750760 @default.
• W4361204667 hasConcept C203014093 @default.
• W4361204667 hasConcept C2776151105 @default.
• W4361204667 hasConcept C2776914184 @default.
• W4361204667 hasConcept C2777209026 @default.
• W4361204667 hasConcept C2780007613 @default.
• W4361204667 hasConcept C28328180 @default.
• W4361204667 hasConcept C522857546 @default.
• W4361204667 hasConcept C86803240 @default.
• W4361204667 hasConcept C95444343 @default.
• W4361204667 hasConceptScore W4361204667C109159458 @default.
• W4361204667 hasConceptScore W4361204667C134018914 @default.
• W4361204667 hasConceptScore W4361204667C201750760 @default.
• W4361204667 hasConceptScore W4361204667C203014093 @default.
• W4361204667 hasConceptScore W4361204667C2776151105 @default.
• W4361204667 hasConceptScore W4361204667C2776914184 @default.
• W4361204667 hasConceptScore W4361204667C2777209026 @default.
• W4361204667 hasConceptScore W4361204667C2780007613 @default.
• W4361204667 hasConceptScore W4361204667C28328180 @default.
• W4361204667 hasConceptScore W4361204667C522857546 @default.
• W4361204667 hasConceptScore W4361204667C86803240 @default.
• W4361204667 hasConceptScore W4361204667C95444343 @default.
• W4361204667 hasFunder F4320322120 @default.
• W4361204667 hasLocation W43612046671 @default.

• next