FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361204841> ?p ?o ?g. }

• W4361204841 endingPage "6367" @default.
• W4361204841 startingPage "6367" @default.
• W4361204841 abstract "The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in a variety of central nervous system disorders and whose agonists have neuroprotective activity. In spite of σ1-R’s physio-pathological and pharmacological importance, two of the most important features required to fully understand σ1-R function, namely the receptor endogenous ligand(s) and the molecular mechanism of ligand access to the binding site, have not yet been unequivocally determined. In this work, we performed molecular dynamics (MD) simulations to help clarify the potential route of access of ligand(s) to the σ1-R binding site, on which discordant results had been reported in the literature. Further, we combined computational and experimental procedures (i.e., virtual screening (VS), electron density map fitting and fluorescence titration experiments) to provide indications about the nature of σ1-R endogenous ligand(s). Our MD simulations on human σ1-R suggested that ligands access the binding site through a cavity that opens on the protein surface in contact with the membrane, in agreement with previous experimental studies on σ1-R from Xenopus laevis. Additionally, steroids were found to be among the preferred σ1-R ligands predicted by VS, and 16,17-didehydroprogesterone was shown by fluorescence titration to bind human σ1-R, with significantly higher affinity than the prototypic σ1-R ligand pridopidine in the same essay. These results support the hypothesis that steroids are among the most important physiological σ1-R ligands." @default.
• W4361204841 created "2023-03-31" @default.
• W4361204841 creator A5000267232 @default.
• W4361204841 creator A5004005837 @default.
• W4361204841 creator A5007685206 @default.
• W4361204841 creator A5032998349 @default.
• W4361204841 creator A5046909312 @default.
• W4361204841 creator A5060832175 @default.
• W4361204841 creator A5071863016 @default.
• W4361204841 creator A5072838208 @default.
• W4361204841 creator A5081679633 @default.
• W4361204841 date "2023-03-28" @default.
• W4361204841 modified "2023-10-01" @default.
• W4361204841 title "Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands" @default.
• W4361204841 cites W1515218878 @default.
• W4361204841 cites W1757990252 @default.
• W4361204841 cites W1875710910 @default.
• W4361204841 cites W1911958566 @default.
• W4361204841 cites W1935434993 @default.
• W4361204841 cites W1971344996 @default.
• W4361204841 cites W1975734016 @default.
• W4361204841 cites W1976499671 @default.
• W4361204841 cites W1977486075 @default.
• W4361204841 cites W1978498560 @default.
• W4361204841 cites W1990842136 @default.
• W4361204841 cites W1991794210 @default.
• W4361204841 cites W2001641653 @default.
• W4361204841 cites W2003532781 @default.
• W4361204841 cites W2015642465 @default.
• W4361204841 cites W2022484181 @default.
• W4361204841 cites W2026638336 @default.
• W4361204841 cites W2027616377 @default.
• W4361204841 cites W2031211058 @default.
• W4361204841 cites W2035266068 @default.
• W4361204841 cites W2038840577 @default.
• W4361204841 cites W2042609185 @default.
• W4361204841 cites W2045536764 @default.
• W4361204841 cites W2049591446 @default.
• W4361204841 cites W2055035610 @default.
• W4361204841 cites W2057477511 @default.
• W4361204841 cites W2067174909 @default.
• W4361204841 cites W2067216985 @default.
• W4361204841 cites W2069123478 @default.
• W4361204841 cites W2081693079 @default.
• W4361204841 cites W2096769282 @default.
• W4361204841 cites W2105668062 @default.
• W4361204841 cites W2108921801 @default.
• W4361204841 cites W2115086145 @default.
• W4361204841 cites W2119079146 @default.
• W4361204841 cites W2123212921 @default.
• W4361204841 cites W2123768693 @default.
• W4361204841 cites W2124065668 @default.
• W4361204841 cites W2128572087 @default.
• W4361204841 cites W2130479394 @default.
• W4361204841 cites W2132629607 @default.
• W4361204841 cites W2134967712 @default.
• W4361204841 cites W2144081223 @default.
• W4361204841 cites W2152997175 @default.
• W4361204841 cites W2159482845 @default.
• W4361204841 cites W2165526004 @default.
• W4361204841 cites W2169546341 @default.
• W4361204841 cites W2171268876 @default.
• W4361204841 cites W2314811232 @default.
• W4361204841 cites W2330718890 @default.
• W4361204841 cites W2558428302 @default.
• W4361204841 cites W2585341756 @default.
• W4361204841 cites W2593259538 @default.
• W4361204841 cites W2595836464 @default.
• W4361204841 cites W2738387201 @default.
• W4361204841 cites W2767891136 @default.
• W4361204841 cites W2939054293 @default.
• W4361204841 cites W2947103054 @default.
• W4361204841 cites W2949926789 @default.
• W4361204841 cites W2972008566 @default.
• W4361204841 cites W2992373811 @default.
• W4361204841 cites W3043173157 @default.
• W4361204841 cites W3098082001 @default.
• W4361204841 cites W3125741175 @default.
• W4361204841 cites W3177828909 @default.
• W4361204841 cites W3205102356 @default.
• W4361204841 cites W3211795435 @default.
• W4361204841 cites W4220787842 @default.
• W4361204841 cites W4294216483 @default.
• W4361204841 cites W4299496276 @default.
• W4361204841 doi "https://doi.org/10.3390/ijms24076367" @default.
• W4361204841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37047338" @default.
• W4361204841 hasPublicationYear "2023" @default.
• W4361204841 type Work @default.
• W4361204841 citedByCount "0" @default.
• W4361204841 crossrefType "journal-article" @default.
• W4361204841 hasAuthorship W4361204841A5000267232 @default.
• W4361204841 hasAuthorship W4361204841A5004005837 @default.
• W4361204841 hasAuthorship W4361204841A5007685206 @default.
• W4361204841 hasAuthorship W4361204841A5032998349 @default.
• W4361204841 hasAuthorship W4361204841A5046909312 @default.
• W4361204841 hasAuthorship W4361204841A5060832175 @default.
• W4361204841 hasAuthorship W4361204841A5071863016 @default.
• W4361204841 hasAuthorship W4361204841A5072838208 @default.

• next