Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361208088> ?p ?o ?g. }
- W4361208088 endingPage "1286" @default.
- W4361208088 startingPage "1262" @default.
- W4361208088 abstract "Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM). Melatonin is the major chronobiotic hormone regulating both circadian rhythm and glucose homeostasis. The rs10830963 (G allele) of the melatonin receptor 1B (MTNR1B) gene has the strongest genetic associations with T2DM according to several genome-wide association studies. The MTNR1B rs10830963 G allele is also associated with disturbed circadian phenotypes and altered melatonin secretion, both factors that can elevate the risk of diabetes. Furthermore, evolutionary studies implied the presence of selection pressure and ethnic diversity in MTNR1B, which was consistent with the thrifty gene hypothesis in T2DM. The rs10830963 G risk allele is associated with delayed melatonin secretion onset in dim-light and prolonged duration of peak melatonin. This delayed melatonin secretion may help human ancestors adapt to famine or food shortages during long nights and early mornings and avoid nocturnal hypoglycemia but confers susceptibility to T2DM due to adequate energy intake in modern society. We provide new insight into the role of MTNR1B variants in T2DM via disturbed circadian rhythms from the perspective of the thrifty gene hypothesis; these data indicate a novel target for the prevention and treatment of susceptible populations with the thrifty genotype." @default.
- W4361208088 created "2023-03-31" @default.
- W4361208088 creator A5011287020 @default.
- W4361208088 creator A5027046805 @default.
- W4361208088 creator A5032683472 @default.
- W4361208088 creator A5041983007 @default.
- W4361208088 creator A5063174892 @default.
- W4361208088 creator A5068112395 @default.
- W4361208088 creator A5089559870 @default.
- W4361208088 date "2023-03-28" @default.
- W4361208088 modified "2023-10-02" @default.
- W4361208088 title "The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story" @default.
- W4361208088 cites W1481045036 @default.
- W4361208088 cites W1485919284 @default.
- W4361208088 cites W1505050831 @default.
- W4361208088 cites W1541471661 @default.
- W4361208088 cites W1598010519 @default.
- W4361208088 cites W1898035990 @default.
- W4361208088 cites W1932521829 @default.
- W4361208088 cites W1964109421 @default.
- W4361208088 cites W1965141016 @default.
- W4361208088 cites W1966902632 @default.
- W4361208088 cites W1967778610 @default.
- W4361208088 cites W1968043731 @default.
- W4361208088 cites W1970446877 @default.
- W4361208088 cites W1970792890 @default.
- W4361208088 cites W1970980171 @default.
- W4361208088 cites W1971958777 @default.
- W4361208088 cites W1977376450 @default.
- W4361208088 cites W1978178232 @default.
- W4361208088 cites W1981452461 @default.
- W4361208088 cites W1982685226 @default.
- W4361208088 cites W1982974848 @default.
- W4361208088 cites W1986608768 @default.
- W4361208088 cites W1986673931 @default.
- W4361208088 cites W1988269619 @default.
- W4361208088 cites W1988550244 @default.
- W4361208088 cites W1994290678 @default.
- W4361208088 cites W1998320088 @default.
- W4361208088 cites W1998342078 @default.
- W4361208088 cites W2002293846 @default.
- W4361208088 cites W2003702559 @default.
- W4361208088 cites W2005421391 @default.
- W4361208088 cites W2008596767 @default.
- W4361208088 cites W2010764945 @default.
- W4361208088 cites W2013112246 @default.
- W4361208088 cites W2016317262 @default.
- W4361208088 cites W2020244868 @default.
- W4361208088 cites W2021697616 @default.
- W4361208088 cites W2021990756 @default.
- W4361208088 cites W2022220021 @default.
- W4361208088 cites W2022442940 @default.
- W4361208088 cites W2024449200 @default.
- W4361208088 cites W2028004193 @default.
- W4361208088 cites W2030018707 @default.
- W4361208088 cites W2033145761 @default.
- W4361208088 cites W2033228845 @default.
- W4361208088 cites W2033759772 @default.
- W4361208088 cites W2036161162 @default.
- W4361208088 cites W2038902313 @default.
- W4361208088 cites W2043165727 @default.
- W4361208088 cites W2050444718 @default.
- W4361208088 cites W2055410610 @default.
- W4361208088 cites W2056229820 @default.
- W4361208088 cites W2059085109 @default.
- W4361208088 cites W2062255180 @default.
- W4361208088 cites W2062790175 @default.
- W4361208088 cites W2064385910 @default.
- W4361208088 cites W2066199795 @default.
- W4361208088 cites W2070371680 @default.
- W4361208088 cites W2070753981 @default.
- W4361208088 cites W2071759640 @default.
- W4361208088 cites W2071881237 @default.
- W4361208088 cites W2074557491 @default.
- W4361208088 cites W2079301735 @default.
- W4361208088 cites W2081029102 @default.
- W4361208088 cites W2082165651 @default.
- W4361208088 cites W2082407123 @default.
- W4361208088 cites W2082790308 @default.
- W4361208088 cites W2083954139 @default.
- W4361208088 cites W2085663109 @default.
- W4361208088 cites W2086677877 @default.
- W4361208088 cites W2086989226 @default.
- W4361208088 cites W2090392937 @default.
- W4361208088 cites W2090634242 @default.
- W4361208088 cites W2091374441 @default.
- W4361208088 cites W2091385411 @default.
- W4361208088 cites W2091705028 @default.
- W4361208088 cites W2091912666 @default.
- W4361208088 cites W2093362931 @default.
- W4361208088 cites W2094816577 @default.
- W4361208088 cites W2097186269 @default.
- W4361208088 cites W2098238559 @default.
- W4361208088 cites W2103920106 @default.
- W4361208088 cites W2107832950 @default.
- W4361208088 cites W2109679032 @default.
- W4361208088 cites W2115218756 @default.
- W4361208088 cites W2116417140 @default.