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• W4361208540 endingPage "3013" @default.
• W4361208540 startingPage "3013" @default.
• W4361208540 abstract "Aflatoxin B1 (AFB1) is a recalcitrant metabolite produced by fungi species, and due to its intoxications in animals and humans, it has been classified as a Group 1 carcinogen in humans. Preserving food products with Sorghum bicolor sheath can minimise the contamination of agricultural products and avert ill health occasioned by exposure to AFB1. The current study investigated the ameliorating effect of Sorghum bicolor sheath hydrophobic extract (SBE-HP) enriched in Apigenin (API) on the hepatorenal tissues of rats exposed to AFB1. The SBE-HP was characterised using TLC and LC-MS and was found to be enriched in Apigenin and its methylated analogues. The study used adult male rats divided into four experimental cohorts co-treated with AFB1 (50 µg/kg) and SBE-HP (5 and 10 mg/kg) for 28 days. Biochemical, enzyme-linked immunosorbent assays (ELISA) and histological staining were used to examine biomarkers of hepatorenal function, oxidative status, inflammation and apoptosis, and hepatorenal tissue histo-architectural alterations. Data were analysed using GraphPad Prism 8.3.0, an independent t-test, and a one-way analysis of variance. Co-treatment with SBE-HP ameliorated an upsurge in the biomarkers of hepatorenal functionality in the sera of rats, reduced the alterations in redox balance, resolved inflammation, inhibited apoptosis, and preserved the histological features of the liver and kidney of rats exposed to AFB1. SBE-HP-containing API is an excellent antioxidant regiment. It can amply prevent the induction of oxidative stress, inflammation, and apoptosis in the hepatorenal system of rats. Therefore, supplementing animal feeds and human foods with SBE-HP enriched in Apigenin may reduce the burden of AFB1 intoxication in developing countries with a shortage of effective antifungal agents." @default.
• W4361208540 created "2023-03-31" @default.
• W4361208540 creator A5000448828 @default.
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• W4361208540 date "2023-03-28" @default.
• W4361208540 modified "2023-10-01" @default.
• W4361208540 title "The Hydrophobic Extract of Sorghum bicolor (L. Moench) Enriched in Apigenin-Protected Rats against Aflatoxin B1-Associated Hepatorenal Derangement" @default.
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• W4361208540 cites W1581414347 @default.
• W4361208540 cites W1750690213 @default.
• W4361208540 cites W1970723735 @default.
• W4361208540 cites W1972537772 @default.
• W4361208540 cites W1972557285 @default.
• W4361208540 cites W1983310681 @default.
• W4361208540 cites W1990802251 @default.
• W4361208540 cites W1994048223 @default.
• W4361208540 cites W1996109844 @default.
• W4361208540 cites W2006370393 @default.
• W4361208540 cites W2008715871 @default.
• W4361208540 cites W2030544852 @default.
• W4361208540 cites W2035817024 @default.
• W4361208540 cites W2038416402 @default.
• W4361208540 cites W2046962183 @default.
• W4361208540 cites W2054850562 @default.
• W4361208540 cites W2059173469 @default.
• W4361208540 cites W2060194897 @default.
• W4361208540 cites W2062515216 @default.
• W4361208540 cites W2073092594 @default.
• W4361208540 cites W2081779137 @default.
• W4361208540 cites W2082881125 @default.
• W4361208540 cites W2085143181 @default.
• W4361208540 cites W2087484885 @default.
• W4361208540 cites W2099287329 @default.
• W4361208540 cites W2099984595 @default.
• W4361208540 cites W2108280647 @default.
• W4361208540 cites W2120848283 @default.
• W4361208540 cites W2122478768 @default.
• W4361208540 cites W2132467422 @default.
• W4361208540 cites W2140100705 @default.
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• W4361208540 cites W2293247286 @default.
• W4361208540 cites W2561520623 @default.
• W4361208540 cites W2565850482 @default.
• W4361208540 cites W2605396129 @default.
• W4361208540 cites W2610715976 @default.
• W4361208540 cites W2782959446 @default.
• W4361208540 cites W2783447142 @default.
• W4361208540 cites W2803021236 @default.
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• W4361208540 cites W2897950718 @default.
• W4361208540 cites W2913590717 @default.
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• W4361208540 cites W2969773000 @default.
• W4361208540 cites W2997763290 @default.
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• W4361208540 cites W3026444499 @default.
• W4361208540 cites W3032801994 @default.
• W4361208540 cites W3035934651 @default.
• W4361208540 cites W3035937590 @default.
• W4361208540 cites W3047271839 @default.
• W4361208540 cites W3080796060 @default.
• W4361208540 cites W3110028318 @default.
• W4361208540 cites W3115223529 @default.
• W4361208540 cites W3119122944 @default.
• W4361208540 cites W3119806864 @default.
• W4361208540 cites W3121866388 @default.
• W4361208540 cites W3147241681 @default.
• W4361208540 cites W3156704618 @default.
• W4361208540 cites W3189502259 @default.
• W4361208540 cites W3195313266 @default.
• W4361208540 cites W3200240103 @default.
• W4361208540 cites W3204188118 @default.
• W4361208540 cites W3206869284 @default.
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• W4361208540 doi "https://doi.org/10.3390/molecules28073013" @default.
• W4361208540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37049776" @default.
• W4361208540 hasPublicationYear "2023" @default.
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