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- W4361213507 endingPage "1713" @default.
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- W4361213507 abstract "Platelets play a central role in the arrest of bleeding. The ability of platelets to engage with extracellular matrix proteins of the subendothelium has long been recognized as a pivotal platelet attribute, underpinning adequate hemostasis. The propensity of platelets to rapidly bind and functionally respond to collagen was one of the earliest documented events in platelet biology. The receptor primarily responsible for mediating platelet/collagen responses was identified as glycoprotein (GP) VI and successfully cloned in 1999. Since that time, this receptor has held the attention of many research groups, and through these efforts, we now have an excellent understanding of the roles of GPVI as a platelet- and megakaryocyte-specific adheso-signaling receptor in platelet biology. GPVI is considered a viable antithrombotic target, as data obtained from groups across the world is consistent with GPVI being less involved in physiological hemostatic processes but participating in arterial thrombosis. This review will highlight the key aspects of GPVI contributions to platelet biology and concentrate on the interaction with recently identified ligands, with a focus on fibrin and fibrinogen, discussing the role of these interactions in the growth and stability of thrombi. We will also discuss important therapeutic developments that target GPVI to modulate platelet function while minimizing bleeding outcomes." @default.
- W4361213507 created "2023-03-31" @default.
- W4361213507 creator A5008277035 @default.
- W4361213507 creator A5032313555 @default.
- W4361213507 creator A5049047494 @default.
- W4361213507 creator A5061171100 @default.
- W4361213507 date "2023-07-01" @default.
- W4361213507 modified "2023-10-06" @default.
- W4361213507 title "Glycoprotein VI interplay with fibrin(ogen) in thrombosis" @default.
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