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- W4361213948 abstract "The aim of our study was to analyze the effect of ATP on possible ovarian damage of 5-FU in rats.The animals were divided to three groups; healthy group (HG), 5-FU alone group (FUG) and ATP+5-FU administered group (AFU). The ATP 4 mg/kg was injected intraperitoneally (IP) into the AFU group. The same volume of saline (0.9% NaCl) as the solvent was administered intraperitoneally to the HG and FUG groups. One hour after administering ATP and solvent, 5-FU 100 mg/kg was injected intraperitoneally to the animals in the AFU and FUG groups. ATP was administered to the animals once a day for 10 days. On the 1st, 3rd and 5th days of 5-FU, one dose (total of 3 doses) was administered. On day 10, the animals were euthanasia with high-dose anaesthesia and ovarian tissues were removed. The removed ovaries were analyzed biochemically andhistopathological.ATP significantly suppressed both the increase in MDA and IL-6 levels, and the decrease in tGSH, SOD and CAT levels. Treatment with ATP significantly suppressed the severe vacuolization and primordial follicle degeneration induced by 5-FU in our study.ATP was possible to be useful for the treatment of 5-FU-induced ovarian damage." @default.
- W4361213948 created "2023-03-31" @default.
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- W4361213948 date "2023-03-01" @default.
- W4361213948 modified "2023-10-16" @default.
- W4361213948 title "Protective Effect of Adenosine Triphosphate against 5-Fluorouracil-Induced Oxidative Ovarian Damage in vivo" @default.
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- W4361213948 doi "https://doi.org/10.31557/apjcp.2023.24.3.1007" @default.
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