Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361215620> ?p ?o ?g. }
- W4361215620 abstract "Intestinal epithelial cells (IECs) constitute a critical first line of defense against microbes. While IECs are known to respond to various microbial signals, the precise upstream cues regulating diverse IEC responses are not clear. Here, we discover a dual role for IEC-intrinsic interleukin-1 receptor (IL-1R) signaling in regulating intestinal homeostasis and inflammation. Absence of IL-1R in epithelial cells abrogates a homeostatic antimicrobial program including production of antimicrobial peptides (AMPs). Mice deficient for IEC-intrinsic IL-1R are unable to clear Citrobacter rodentium (C. rodentium) but are protected from DSS-induced colitis. Mechanistically, IL-1R signaling enhances IL-22R-induced signal transducer and activator of transcription 3 (STAT3) phosphorylation in IECs leading to elevated production of AMPs. IL-1R signaling in IECs also directly induces expression of chemokines as well as genes involved in the production of reactive oxygen species. Our findings establish a protective role for IEC-intrinsic IL-1R signaling in combating infections but a detrimental role during colitis induced by epithelial damage." @default.
- W4361215620 created "2023-03-31" @default.
- W4361215620 creator A5002984702 @default.
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- W4361215620 creator A5091009164 @default.
- W4361215620 date "2023-03-28" @default.
- W4361215620 modified "2023-10-18" @default.
- W4361215620 title "IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation" @default.
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