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• W4361218330 abstract "Background In this nationwide population-based cohort study, we investigated the overall minimum margin width that is independently associated with improved survival following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) and evaluated whether certain margins or surfaces hold independent prognostic significance. Methods Data from 367 patients who underwent PD for PDAC in the period 2015–2019 were retrieved from the Danish Pancreatic Cancer Database. Missing data were obtained by review of pathology reports and re-microscopy of resection specimens. Surgical specimens were evaluated using a standardised pathological protocol involving multicolour inking, axial slicing and exact reporting of circumferential margin clearances in 0.5 mm increments. Results When categorised according to margin widths of <0.5, <1.0, <1.5, <2.0, <2.5 and <3.0 mm, R1 resections were detected in 34%, 57%, 75%, 78%, 86% and 87% of cases, respectively. In multivariable analyses, an overall margin clearance of ≥1.5 mm was associated with improved survival compared with a clearance of <1.5 mm (HR 0.70 95% CI 0.51–0.97 (p = 0.031)). When evaluating the margins separately, no margin had independent prognostic significance. Conclusion Margin clearance of at least 1.5 mm was independently associated with improved survival following PD for PDAC." @default.
• W4361218330 created "2023-03-31" @default.
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• W4361218330 date "2023-07-01" @default.
• W4361218330 modified "2023-10-18" @default.
• W4361218330 title "Prognostic significance of margin clearance in pancreaticoduodenectomy specimens with pancreatic ductal adenocarcinoma in a Danish population-based nationwide study" @default.
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• W4361218330 doi "https://doi.org/10.1016/j.hpb.2023.03.016" @default.
• W4361218330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37173163" @default.
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