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- W4361218933 abstract "A State of the Art lecture titled Personalizing Antiplatelet Therapy Based on Platelet Turnover and Metabolic Phenotype was presented by Bianca Rocca at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2022. Increased variability in drug response may be associated with serious, mechanism-based and off-target side effects, especially in the case of drugs that do not routinely undergo therapeutic drug monitoring, such as antiplatelet drugs or direct oral anticoagulants. Precision pharmacology can be defined as the identification of a drug regimen that maximizes the benefit/risk balance at the level of an individual patient. Key tools for identifying relevant sources of variability and developing precision drug dosing are represented by genetic, biochemical, and pharmacological biomarkers recognized as a valid surrogate or strong predictor of major clinical complications. Pharmacodynamic, pharmacokinetic, and/or disease-related biomarkers are central to identifying the right population to be targeted, characterizing the sources of variability in drug response, guiding precision treatments that maximize benefits and minimize risks, and designing precision dosing trials. Another valuable tool for guiding precision pharmacology is represented by in silico pharmacokinetic/pharmacodynamic models and simulations instructed by real-world data of validated biomarkers. This review critically analyzes the tools for precision dosing and exemplifies conditions in which precision dosing can considerably optimize the efficacy and safety of antiplatelet drugs, namely aspirin and P2Y12 receptor blockers, used alone and in combination. Finally, we summarize relevant new data on this topic presented during the 2022 ISTH Congress." @default.
- W4361218933 created "2023-03-31" @default.
- W4361218933 creator A5037962146 @default.
- W4361218933 creator A5057207523 @default.
- W4361218933 date "2023-03-01" @default.
- W4361218933 modified "2023-10-01" @default.
- W4361218933 title "Precision antiplatelet therapy" @default.
- W4361218933 cites W107715711 @default.
- W4361218933 cites W1501922076 @default.
- W4361218933 cites W1523885354 @default.
- W4361218933 cites W1630039729 @default.
- W4361218933 cites W1709234658 @default.
- W4361218933 cites W1750665238 @default.
- W4361218933 cites W1861694954 @default.
- W4361218933 cites W1928941855 @default.
- W4361218933 cites W1981260144 @default.
- W4361218933 cites W1985059672 @default.
- W4361218933 cites W1986073508 @default.
- W4361218933 cites W1990476076 @default.
- W4361218933 cites W1991372259 @default.
- W4361218933 cites W2009530504 @default.
- W4361218933 cites W2011861566 @default.
- W4361218933 cites W2012369487 @default.
- W4361218933 cites W2014644245 @default.
- W4361218933 cites W2017299352 @default.
- W4361218933 cites W2018670288 @default.
- W4361218933 cites W2045934073 @default.
- W4361218933 cites W2054008451 @default.
- W4361218933 cites W2097657831 @default.
- W4361218933 cites W2110861336 @default.
- W4361218933 cites W2112357684 @default.
- W4361218933 cites W2115854144 @default.
- W4361218933 cites W2118079068 @default.
- W4361218933 cites W2118300357 @default.
- W4361218933 cites W2125389594 @default.
- W4361218933 cites W2138597449 @default.
- W4361218933 cites W2140261980 @default.
- W4361218933 cites W2145323902 @default.
- W4361218933 cites W2147195562 @default.
- W4361218933 cites W2150959326 @default.
- W4361218933 cites W2154940301 @default.
- W4361218933 cites W2157833432 @default.
- W4361218933 cites W2159858918 @default.
- W4361218933 cites W2170112844 @default.
- W4361218933 cites W2170949977 @default.
- W4361218933 cites W2293189561 @default.
- W4361218933 cites W2385547 @default.
- W4361218933 cites W2402119165 @default.
- W4361218933 cites W2460422691 @default.
- W4361218933 cites W2472420285 @default.
- W4361218933 cites W2478356558 @default.
- W4361218933 cites W2509918966 @default.
- W4361218933 cites W2512694359 @default.
- W4361218933 cites W2521494339 @default.
- W4361218933 cites W2546826621 @default.
- W4361218933 cites W2604114528 @default.
- W4361218933 cites W2604835455 @default.
- W4361218933 cites W2792176836 @default.
- W4361218933 cites W2792364309 @default.
- W4361218933 cites W2805991204 @default.
- W4361218933 cites W2905839804 @default.
- W4361218933 cites W2934572398 @default.
- W4361218933 cites W2946137898 @default.
- W4361218933 cites W2954118209 @default.
- W4361218933 cites W2963599700 @default.
- W4361218933 cites W2982343288 @default.
- W4361218933 cites W2998925776 @default.
- W4361218933 cites W3015123096 @default.
- W4361218933 cites W3019788133 @default.
- W4361218933 cites W3043324822 @default.
- W4361218933 cites W3081450704 @default.
- W4361218933 cites W3088307847 @default.
- W4361218933 cites W3112837127 @default.
- W4361218933 cites W3117496643 @default.
- W4361218933 cites W3123453085 @default.
- W4361218933 cites W3136745123 @default.
- W4361218933 cites W3139080159 @default.
- W4361218933 cites W3162833931 @default.
- W4361218933 cites W3196271835 @default.
- W4361218933 cites W3197233987 @default.
- W4361218933 cites W3211312200 @default.
- W4361218933 cites W4206592184 @default.
- W4361218933 cites W4207040168 @default.
- W4361218933 cites W4210259415 @default.
- W4361218933 cites W4212868611 @default.
- W4361218933 cites W4213338231 @default.
- W4361218933 cites W4224295384 @default.
- W4361218933 cites W4224317096 @default.
- W4361218933 cites W4244537139 @default.
- W4361218933 cites W4245466284 @default.
- W4361218933 cites W4281759299 @default.
- W4361218933 cites W4285038159 @default.
- W4361218933 cites W4286253180 @default.
- W4361218933 cites W4288751699 @default.
- W4361218933 cites W4289223986 @default.
- W4361218933 cites W4290633377 @default.
- W4361218933 cites W4293066137 @default.
- W4361218933 cites W4302287398 @default.