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- W4361223851 endingPage "1845.e5" @default.
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- W4361223851 abstract "•Best memory recall if retrieval neural state matches encoding (encoding specificity) •Memory thought to be stored in engram (engram neurons) •Across conditions, engram optimally reactivated if retrieval state matches encoding •Engram encoding specificity observed across multiple match/mismatch conditions According to the encoding specificity hypothesis, memory is best recalled by retrieval cues that overlap with training cues. Human studies generally support this hypothesis. However, memories are thought to be stored in neuronal ensembles (engrams), and retrieval cues are thought to reactivate neurons in an engram to induce memory recall. Here, we visualized engrams in mice to test whether retrieval cues that overlap with training cues produce maximal memory recall via high engram reactivation (engram encoding specificity hypothesis). Using variations of cued threat conditioning (pairing conditioned stimulus [CS] with footshock), we manipulated encoding and retrieval conditions along multiple domains, including pharmacological state, external sensory cue, and internal optogenetic cue. Maximal engram reactivation and memory recall occurred when retrieval conditions closely matched training conditions. These findings provide a biological basis for the encoding specificity hypothesis and highlight the important interaction between stored information (engram) and cues available at memory retrieval (ecphory). According to the encoding specificity hypothesis, memory is best recalled by retrieval cues that overlap with training cues. Human studies generally support this hypothesis. However, memories are thought to be stored in neuronal ensembles (engrams), and retrieval cues are thought to reactivate neurons in an engram to induce memory recall. Here, we visualized engrams in mice to test whether retrieval cues that overlap with training cues produce maximal memory recall via high engram reactivation (engram encoding specificity hypothesis). Using variations of cued threat conditioning (pairing conditioned stimulus [CS] with footshock), we manipulated encoding and retrieval conditions along multiple domains, including pharmacological state, external sensory cue, and internal optogenetic cue. Maximal engram reactivation and memory recall occurred when retrieval conditions closely matched training conditions. These findings provide a biological basis for the encoding specificity hypothesis and highlight the important interaction between stored information (engram) and cues available at memory retrieval (ecphory)." @default.
- W4361223851 created "2023-03-31" @default.
- W4361223851 creator A5010985976 @default.
- W4361223851 creator A5015347221 @default.
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- W4361223851 creator A5076316263 @default.
- W4361223851 creator A5080361179 @default.
- W4361223851 creator A5083141368 @default.
- W4361223851 date "2023-06-01" @default.
- W4361223851 modified "2023-10-17" @default.
- W4361223851 title "Examining the engram encoding specificity hypothesis in mice" @default.
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