Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361223870> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4361223870 endingPage "38" @default.
- W4361223870 startingPage "36" @default.
- W4361223870 abstract "Cognitive impairment associated with memory loss and dysfunctional communication is a common condition in older people. Regions of the brain have been reported to decrease in size with increasing age, but the relationship with cognitive impairment is not well understood. Inbred and hybrid mouse strains can be useful models to investigate cognitive impairment and morphological changes at older ages. CB6F1 hybrid mice, a cross between C57BL/6 and Balb/c mice, were tested for learning and memory using a radial water tread maze. Old CB6F1 male mice (30 months of age) had severe cognitive impairment, while it was virtually absent in young (6 months old) male mice. In these same mice, there was a significant decrease in sagittal flat surface area of the hippocampus and pons in old versus young animals. The aging CB6F1 mouse would be a potential model to study the relationship between changes in brain morphometry and cognitive impairment and the identification of possible therapeutic targets. Keywords: CB6F1 mouse, cognitive impairment, aging, brain size, mouse model of brain aging" @default.
- W4361223870 created "2023-03-31" @default.
- W4361223870 creator A5016579629 @default.
- W4361223870 creator A5032862480 @default.
- W4361223870 creator A5073566379 @default.
- W4361223870 date "2023-03-29" @default.
- W4361223870 modified "2023-10-01" @default.
- W4361223870 title "The CB6F1 mouse is a model for studying cognition and brain morphometry with increasing age" @default.
- W4361223870 cites W2045892248 @default.
- W4361223870 cites W2057495929 @default.
- W4361223870 cites W2074615812 @default.
- W4361223870 cites W2088762260 @default.
- W4361223870 cites W2221276418 @default.
- W4361223870 cites W2510560444 @default.
- W4361223870 doi "https://doi.org/10.31491/apt.2023.03.110" @default.
- W4361223870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37427388" @default.
- W4361223870 hasPublicationYear "2023" @default.
- W4361223870 type Work @default.
- W4361223870 citedByCount "0" @default.
- W4361223870 crossrefType "journal-article" @default.
- W4361223870 hasAuthorship W4361223870A5016579629 @default.
- W4361223870 hasAuthorship W4361223870A5032862480 @default.
- W4361223870 hasAuthorship W4361223870A5073566379 @default.
- W4361223870 hasBestOaLocation W43612238701 @default.
- W4361223870 hasConcept C126838900 @default.
- W4361223870 hasConcept C143409427 @default.
- W4361223870 hasConcept C145940234 @default.
- W4361223870 hasConcept C15744967 @default.
- W4361223870 hasConcept C169760540 @default.
- W4361223870 hasConcept C169900460 @default.
- W4361223870 hasConcept C27502469 @default.
- W4361223870 hasConcept C2781161787 @default.
- W4361223870 hasConcept C2984915365 @default.
- W4361223870 hasConcept C3018842126 @default.
- W4361223870 hasConcept C44752575 @default.
- W4361223870 hasConcept C70410870 @default.
- W4361223870 hasConcept C71924100 @default.
- W4361223870 hasConceptScore W4361223870C126838900 @default.
- W4361223870 hasConceptScore W4361223870C143409427 @default.
- W4361223870 hasConceptScore W4361223870C145940234 @default.
- W4361223870 hasConceptScore W4361223870C15744967 @default.
- W4361223870 hasConceptScore W4361223870C169760540 @default.
- W4361223870 hasConceptScore W4361223870C169900460 @default.
- W4361223870 hasConceptScore W4361223870C27502469 @default.
- W4361223870 hasConceptScore W4361223870C2781161787 @default.
- W4361223870 hasConceptScore W4361223870C2984915365 @default.
- W4361223870 hasConceptScore W4361223870C3018842126 @default.
- W4361223870 hasConceptScore W4361223870C44752575 @default.
- W4361223870 hasConceptScore W4361223870C70410870 @default.
- W4361223870 hasConceptScore W4361223870C71924100 @default.
- W4361223870 hasIssue "1" @default.
- W4361223870 hasLocation W43612238701 @default.
- W4361223870 hasLocation W43612238702 @default.
- W4361223870 hasLocation W43612238703 @default.
- W4361223870 hasOpenAccess W4361223870 @default.
- W4361223870 hasPrimaryLocation W43612238701 @default.
- W4361223870 hasRelatedWork W2089457649 @default.
- W4361223870 hasRelatedWork W2276044357 @default.
- W4361223870 hasRelatedWork W2345315666 @default.
- W4361223870 hasRelatedWork W2357692759 @default.
- W4361223870 hasRelatedWork W2377078577 @default.
- W4361223870 hasRelatedWork W2588028524 @default.
- W4361223870 hasRelatedWork W2624674285 @default.
- W4361223870 hasRelatedWork W3146087251 @default.
- W4361223870 hasRelatedWork W3157191973 @default.
- W4361223870 hasRelatedWork W4239691505 @default.
- W4361223870 hasVolume "5" @default.
- W4361223870 isParatext "false" @default.
- W4361223870 isRetracted "false" @default.
- W4361223870 workType "article" @default.