FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361234540> ?p ?o ?g. }

• W4361234540 abstract "<div>Abstract<p>Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, but it still lacks effective treatment options. In this study, we utilized proteomic technology to identify lipolysis-stimulated lipoprotein receptor (LSR) as a new tumor antigen of EOC. Immunohistochemical analysis of EOC tissues in conjunction with survival analysis of EOC patients showed that high expression of LSR is associated with poor prognosis. High LSR expression also occurred in tumor metastases including to the lymph node and omentum. To evaluate the possible benefits of blocking this antigen in EOC, we raised a new monoclonal antibody (mAb) to human LSR (hLSR). In mouse xenograft models of hLSR⁺ EOC (cell lines or patient-derived tumors), we found that administration of anti-hLSR mAb inhibited tumor growth in a manner independent of both antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Mechanistic investigations showed that hLSR expression increased incorporation of very-low-density lipoprotein (VLDL) into EOC cells and that anti-hLSR mAb inhibited lipid uptake <i>in vitro</i> and <i>in vivo</i>. Moreover, VLDL promoted cell proliferation in hLSR-positive EOC cells <i>in vitro</i>, and this effect was inhibited by anti-hLSR mAb. While the anti-hLSR mAb studied cross reacted with the mouse antigen, we observed no adverse effects on normal organs and lipid metabolism in murine hosts. Our findings suggest that hLSR plays a key functional role in EOC development and that this antigen can be therapeutically targeted by specific mAb to improve EOC treatment.</p><p><b>Significance:</b> These findings offer preclinical evidence of the therapeutic efficacy of a novel targeted antibody therapy against deadly epithelial ovarian cancers. <i>Cancer Res; 78(2); 516–27. ©2017 AACR</i>.</p></div>" @default.
• W4361234540 created "2023-03-31" @default.
• W4361234540 creator A5002638004 @default.
• W4361234540 creator A5007987129 @default.
• W4361234540 creator A5009314886 @default.
• W4361234540 creator A5013910008 @default.
• W4361234540 creator A5018600874 @default.
• W4361234540 creator A5020771892 @default.
• W4361234540 creator A5026657616 @default.
• W4361234540 creator A5031128573 @default.
• W4361234540 creator A5046856618 @default.
• W4361234540 creator A5049747685 @default.
• W4361234540 creator A5055405608 @default.
• W4361234540 creator A5056238856 @default.
• W4361234540 creator A5056561389 @default.
• W4361234540 creator A5058902589 @default.
• W4361234540 creator A5063515948 @default.
• W4361234540 creator A5071731375 @default.
• W4361234540 creator A5084323300 @default.
• W4361234540 date "2023-03-31" @default.
• W4361234540 modified "2023-10-16" @default.
• W4361234540 title "Data from LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake" @default.
• W4361234540 doi "https://doi.org/10.1158/0008-5472.c.6509988.v1" @default.
• W4361234540 hasPublicationYear "2023" @default.
• W4361234540 type Work @default.
• W4361234540 citedByCount "0" @default.
• W4361234540 crossrefType "posted-content" @default.
• W4361234540 hasAuthorship W4361234540A5002638004 @default.
• W4361234540 hasAuthorship W4361234540A5007987129 @default.
• W4361234540 hasAuthorship W4361234540A5009314886 @default.
• W4361234540 hasAuthorship W4361234540A5013910008 @default.
• W4361234540 hasAuthorship W4361234540A5018600874 @default.
• W4361234540 hasAuthorship W4361234540A5020771892 @default.
• W4361234540 hasAuthorship W4361234540A5026657616 @default.
• W4361234540 hasAuthorship W4361234540A5031128573 @default.
• W4361234540 hasAuthorship W4361234540A5046856618 @default.
• W4361234540 hasAuthorship W4361234540A5049747685 @default.
• W4361234540 hasAuthorship W4361234540A5055405608 @default.
• W4361234540 hasAuthorship W4361234540A5056238856 @default.
• W4361234540 hasAuthorship W4361234540A5056561389 @default.
• W4361234540 hasAuthorship W4361234540A5058902589 @default.
• W4361234540 hasAuthorship W4361234540A5063515948 @default.
• W4361234540 hasAuthorship W4361234540A5071731375 @default.
• W4361234540 hasAuthorship W4361234540A5084323300 @default.
• W4361234540 hasConcept C109316439 @default.
• W4361234540 hasConcept C121608353 @default.
• W4361234540 hasConcept C126322002 @default.
• W4361234540 hasConcept C147483822 @default.
• W4361234540 hasConcept C150903083 @default.
• W4361234540 hasConcept C153911025 @default.
• W4361234540 hasConcept C159654299 @default.
• W4361234540 hasConcept C185592680 @default.
• W4361234540 hasConcept C202751555 @default.
• W4361234540 hasConcept C203014093 @default.
• W4361234540 hasConcept C207001950 @default.
• W4361234540 hasConcept C2780427987 @default.
• W4361234540 hasConcept C502942594 @default.
• W4361234540 hasConcept C542903549 @default.
• W4361234540 hasConcept C55493867 @default.
• W4361234540 hasConcept C71924100 @default.
• W4361234540 hasConcept C86803240 @default.
• W4361234540 hasConceptScore W4361234540C109316439 @default.
• W4361234540 hasConceptScore W4361234540C121608353 @default.
• W4361234540 hasConceptScore W4361234540C126322002 @default.
• W4361234540 hasConceptScore W4361234540C147483822 @default.
• W4361234540 hasConceptScore W4361234540C150903083 @default.
• W4361234540 hasConceptScore W4361234540C153911025 @default.
• W4361234540 hasConceptScore W4361234540C159654299 @default.
• W4361234540 hasConceptScore W4361234540C185592680 @default.
• W4361234540 hasConceptScore W4361234540C202751555 @default.
• W4361234540 hasConceptScore W4361234540C203014093 @default.
• W4361234540 hasConceptScore W4361234540C207001950 @default.
• W4361234540 hasConceptScore W4361234540C2780427987 @default.
• W4361234540 hasConceptScore W4361234540C502942594 @default.
• W4361234540 hasConceptScore W4361234540C542903549 @default.
• W4361234540 hasConceptScore W4361234540C55493867 @default.
• W4361234540 hasConceptScore W4361234540C71924100 @default.
• W4361234540 hasConceptScore W4361234540C86803240 @default.
• W4361234540 hasLocation W43612345401 @default.
• W4361234540 hasOpenAccess W4361234540 @default.
• W4361234540 hasPrimaryLocation W43612345401 @default.
• W4361234540 hasRelatedWork W1592261125 @default.
• W4361234540 hasRelatedWork W1973692620 @default.
• W4361234540 hasRelatedWork W1982027601 @default.
• W4361234540 hasRelatedWork W2064089409 @default.
• W4361234540 hasRelatedWork W2368460920 @default.
• W4361234540 hasRelatedWork W2380360044 @default.
• W4361234540 hasRelatedWork W2443772760 @default.
• W4361234540 hasRelatedWork W2464301138 @default.
• W4361234540 hasRelatedWork W2517050254 @default.
• W4361234540 hasRelatedWork W3143432856 @default.
• W4361234540 isParatext "false" @default.
• W4361234540 isRetracted "false" @default.
• W4361234540 workType "article" @default.