Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361237900> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4361237900 abstract "<div>Abstract<p>Breast cancer is the most common cancer among women worldwide, yet successful treatment remains a clinical challenge. Ivermectin, a broad-spectrum antiparasitic drug, has recently been characterized as a potential anticancer agent due to observed antitumor effects. However, the molecular mechanisms involved remain poorly understood. Here, we report a role for ivermectin in breast cancer suppression by activating cytostatic autophagy both <i>in vitro</i> and <i>in vivo</i>. Mechanistically, ivermectin-induced autophagy in breast cancer cells is associated with decreased P21-activated kinase 1 (PAK1) expression via the ubiquitination-mediated degradation pathway. The inhibition of PAK1 decreases the phosphorylation level of Akt, resulting in the blockade of the Akt/mTOR signaling pathway. In breast cancer xenografts, the ivermectin-induced cytostatic autophagy leads to suppression of tumor growth. Together, our results provide a molecular basis for the use of ivermectin to inhibit the proliferation of breast cancer cells and indicate that ivermectin is a potential option for the treatment of breast cancer. <i>Cancer Res; 76(15); 4457–69. ©2016 AACR</i>.</p></div>" @default.
- W4361237900 created "2023-03-31" @default.
- W4361237900 creator A5016414843 @default.
- W4361237900 creator A5017642778 @default.
- W4361237900 creator A5021561362 @default.
- W4361237900 creator A5028151790 @default.
- W4361237900 creator A5030699864 @default.
- W4361237900 creator A5031792222 @default.
- W4361237900 creator A5037458498 @default.
- W4361237900 creator A5039607842 @default.
- W4361237900 creator A5044757881 @default.
- W4361237900 creator A5051363890 @default.
- W4361237900 creator A5056106013 @default.
- W4361237900 creator A5063727322 @default.
- W4361237900 creator A5071941735 @default.
- W4361237900 creator A5090166634 @default.
- W4361237900 creator A5090403310 @default.
- W4361237900 date "2023-03-30" @default.
- W4361237900 modified "2023-09-24" @default.
- W4361237900 title "Data from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer" @default.
- W4361237900 doi "https://doi.org/10.1158/0008-5472.c.6507954" @default.
- W4361237900 hasPublicationYear "2023" @default.
- W4361237900 type Work @default.
- W4361237900 citedByCount "0" @default.
- W4361237900 crossrefType "posted-content" @default.
- W4361237900 hasAuthorship W4361237900A5016414843 @default.
- W4361237900 hasAuthorship W4361237900A5017642778 @default.
- W4361237900 hasAuthorship W4361237900A5021561362 @default.
- W4361237900 hasAuthorship W4361237900A5028151790 @default.
- W4361237900 hasAuthorship W4361237900A5030699864 @default.
- W4361237900 hasAuthorship W4361237900A5031792222 @default.
- W4361237900 hasAuthorship W4361237900A5037458498 @default.
- W4361237900 hasAuthorship W4361237900A5039607842 @default.
- W4361237900 hasAuthorship W4361237900A5044757881 @default.
- W4361237900 hasAuthorship W4361237900A5051363890 @default.
- W4361237900 hasAuthorship W4361237900A5056106013 @default.
- W4361237900 hasAuthorship W4361237900A5063727322 @default.
- W4361237900 hasAuthorship W4361237900A5071941735 @default.
- W4361237900 hasAuthorship W4361237900A5090166634 @default.
- W4361237900 hasAuthorship W4361237900A5090403310 @default.
- W4361237900 hasConcept C11960822 @default.
- W4361237900 hasConcept C121608353 @default.
- W4361237900 hasConcept C126322002 @default.
- W4361237900 hasConcept C150903083 @default.
- W4361237900 hasConcept C184235292 @default.
- W4361237900 hasConcept C190283241 @default.
- W4361237900 hasConcept C203522944 @default.
- W4361237900 hasConcept C207001950 @default.
- W4361237900 hasConcept C24901178 @default.
- W4361237900 hasConcept C2777499811 @default.
- W4361237900 hasConcept C42972112 @default.
- W4361237900 hasConcept C502942594 @default.
- W4361237900 hasConcept C530470458 @default.
- W4361237900 hasConcept C55493867 @default.
- W4361237900 hasConcept C62478195 @default.
- W4361237900 hasConcept C71924100 @default.
- W4361237900 hasConcept C75217442 @default.
- W4361237900 hasConcept C86554907 @default.
- W4361237900 hasConcept C86803240 @default.
- W4361237900 hasConcept C95444343 @default.
- W4361237900 hasConcept C98274493 @default.
- W4361237900 hasConceptScore W4361237900C11960822 @default.
- W4361237900 hasConceptScore W4361237900C121608353 @default.
- W4361237900 hasConceptScore W4361237900C126322002 @default.
- W4361237900 hasConceptScore W4361237900C150903083 @default.
- W4361237900 hasConceptScore W4361237900C184235292 @default.
- W4361237900 hasConceptScore W4361237900C190283241 @default.
- W4361237900 hasConceptScore W4361237900C203522944 @default.
- W4361237900 hasConceptScore W4361237900C207001950 @default.
- W4361237900 hasConceptScore W4361237900C24901178 @default.
- W4361237900 hasConceptScore W4361237900C2777499811 @default.
- W4361237900 hasConceptScore W4361237900C42972112 @default.
- W4361237900 hasConceptScore W4361237900C502942594 @default.
- W4361237900 hasConceptScore W4361237900C530470458 @default.
- W4361237900 hasConceptScore W4361237900C55493867 @default.
- W4361237900 hasConceptScore W4361237900C62478195 @default.
- W4361237900 hasConceptScore W4361237900C71924100 @default.
- W4361237900 hasConceptScore W4361237900C75217442 @default.
- W4361237900 hasConceptScore W4361237900C86554907 @default.
- W4361237900 hasConceptScore W4361237900C86803240 @default.
- W4361237900 hasConceptScore W4361237900C95444343 @default.
- W4361237900 hasConceptScore W4361237900C98274493 @default.
- W4361237900 hasLocation W43612379001 @default.
- W4361237900 hasOpenAccess W4361237900 @default.
- W4361237900 hasPrimaryLocation W43612379001 @default.
- W4361237900 hasRelatedWork W2045005486 @default.
- W4361237900 hasRelatedWork W2047115263 @default.
- W4361237900 hasRelatedWork W2127153258 @default.
- W4361237900 hasRelatedWork W2135050229 @default.
- W4361237900 hasRelatedWork W2369110093 @default.
- W4361237900 hasRelatedWork W2388733637 @default.
- W4361237900 hasRelatedWork W2534134632 @default.
- W4361237900 hasRelatedWork W2944620552 @default.
- W4361237900 hasRelatedWork W3089957099 @default.
- W4361237900 hasRelatedWork W4296120550 @default.
- W4361237900 isParatext "false" @default.
- W4361237900 isRetracted "false" @default.
- W4361237900 workType "article" @default.