Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361238527> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4361238527 abstract "<div>Abstract<p>Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenoviral transfer to bone marrow–derived DC, this chimeric receptor (CR) induced nuclear factor-κB (NF-κB)–dependent DC activation and effector function when cultured with immobilized ErbB2 protein or ErbB2-positive tumor cells <i>in vitro. In vivo</i> migration assays showed that ∼40% injected CR-modified DC (scFv-CD40-DC) effectively migrated to ErbB2-positive tumors, where they were activated after ErbB2 antigen stimulation, and sequentially homed into the draining lymph nodes. In murine ErbB2-positive D2F2/E2 breast tumor (BALB/c) and EL4/E2 thymoma (C57BL/6) models, i.v. injection of 1 × 10<sup>6</sup> scFv-CD40-DC significantly inhibited tumor growth and cured established tumors. Importantly, the cured mice treated by injection of scFv-CD40-DC were effective in preventing both ErbB2-positive and parental ErbB2-negative tumor rechallenge. Analysis of the underlying mechanism revealed that i.v. infusion of scFv-CD40-DC elicited tumor-specific CTL responses, and the transfer of CTLs from scFv-CD40-DC–treated mice protected naive mice against a subsequent tumor challenge. These results support the concept that genetic modification of DC with tumor-associated antigen-specific CD40 chimeric receptor might be a useful strategy for treatment of human cancers. [Cancer Res 2008;68(10):3854–62]</p></div>" @default.
- W4361238527 created "2023-03-31" @default.
- W4361238527 creator A5014528965 @default.
- W4361238527 creator A5021231933 @default.
- W4361238527 creator A5024970317 @default.
- W4361238527 creator A5034570457 @default.
- W4361238527 creator A5059854792 @default.
- W4361238527 creator A5074016021 @default.
- W4361238527 creator A5077885692 @default.
- W4361238527 creator A5079656430 @default.
- W4361238527 creator A5080102032 @default.
- W4361238527 creator A5084547085 @default.
- W4361238527 date "2023-03-30" @default.
- W4361238527 modified "2023-10-16" @default.
- W4361238527 title "Data from Cancer Immunotherapy Using <i>In vitro</i> Genetically Modified Targeted Dendritic Cells" @default.
- W4361238527 doi "https://doi.org/10.1158/0008-5472.c.6497697" @default.
- W4361238527 hasPublicationYear "2023" @default.
- W4361238527 type Work @default.
- W4361238527 citedByCount "0" @default.
- W4361238527 crossrefType "posted-content" @default.
- W4361238527 hasAuthorship W4361238527A5014528965 @default.
- W4361238527 hasAuthorship W4361238527A5021231933 @default.
- W4361238527 hasAuthorship W4361238527A5024970317 @default.
- W4361238527 hasAuthorship W4361238527A5034570457 @default.
- W4361238527 hasAuthorship W4361238527A5059854792 @default.
- W4361238527 hasAuthorship W4361238527A5074016021 @default.
- W4361238527 hasAuthorship W4361238527A5077885692 @default.
- W4361238527 hasAuthorship W4361238527A5079656430 @default.
- W4361238527 hasAuthorship W4361238527A5080102032 @default.
- W4361238527 hasAuthorship W4361238527A5084547085 @default.
- W4361238527 hasConcept C147483822 @default.
- W4361238527 hasConcept C147969180 @default.
- W4361238527 hasConcept C150903083 @default.
- W4361238527 hasConcept C153911025 @default.
- W4361238527 hasConcept C154317977 @default.
- W4361238527 hasConcept C167672396 @default.
- W4361238527 hasConcept C185592680 @default.
- W4361238527 hasConcept C202751555 @default.
- W4361238527 hasConcept C203014093 @default.
- W4361238527 hasConcept C207001950 @default.
- W4361238527 hasConcept C2776090121 @default.
- W4361238527 hasConcept C2776662205 @default.
- W4361238527 hasConcept C2777701055 @default.
- W4361238527 hasConcept C39347974 @default.
- W4361238527 hasConcept C502942594 @default.
- W4361238527 hasConcept C55493867 @default.
- W4361238527 hasConcept C86803240 @default.
- W4361238527 hasConcept C8891405 @default.
- W4361238527 hasConcept C90375314 @default.
- W4361238527 hasConceptScore W4361238527C147483822 @default.
- W4361238527 hasConceptScore W4361238527C147969180 @default.
- W4361238527 hasConceptScore W4361238527C150903083 @default.
- W4361238527 hasConceptScore W4361238527C153911025 @default.
- W4361238527 hasConceptScore W4361238527C154317977 @default.
- W4361238527 hasConceptScore W4361238527C167672396 @default.
- W4361238527 hasConceptScore W4361238527C185592680 @default.
- W4361238527 hasConceptScore W4361238527C202751555 @default.
- W4361238527 hasConceptScore W4361238527C203014093 @default.
- W4361238527 hasConceptScore W4361238527C207001950 @default.
- W4361238527 hasConceptScore W4361238527C2776090121 @default.
- W4361238527 hasConceptScore W4361238527C2776662205 @default.
- W4361238527 hasConceptScore W4361238527C2777701055 @default.
- W4361238527 hasConceptScore W4361238527C39347974 @default.
- W4361238527 hasConceptScore W4361238527C502942594 @default.
- W4361238527 hasConceptScore W4361238527C55493867 @default.
- W4361238527 hasConceptScore W4361238527C86803240 @default.
- W4361238527 hasConceptScore W4361238527C8891405 @default.
- W4361238527 hasConceptScore W4361238527C90375314 @default.
- W4361238527 hasLocation W43612385271 @default.
- W4361238527 hasOpenAccess W4361238527 @default.
- W4361238527 hasPrimaryLocation W43612385271 @default.
- W4361238527 hasRelatedWork W1937682064 @default.
- W4361238527 hasRelatedWork W1975011225 @default.
- W4361238527 hasRelatedWork W1988241479 @default.
- W4361238527 hasRelatedWork W1995781391 @default.
- W4361238527 hasRelatedWork W2032597637 @default.
- W4361238527 hasRelatedWork W2043241288 @default.
- W4361238527 hasRelatedWork W2328013749 @default.
- W4361238527 hasRelatedWork W2416350818 @default.
- W4361238527 hasRelatedWork W4361238527 @default.
- W4361238527 hasRelatedWork W4361244139 @default.
- W4361238527 isParatext "false" @default.
- W4361238527 isRetracted "false" @default.
- W4361238527 workType "article" @default.