FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361241768> ?p ?o ?g. }

• W4361241768 abstract "<div>Abstract<p>The mitochondrial transcription factor A (TFAM) is required for mitochondrial DNA (mtDNA) replication and transcription. Disruption of TFAM results in heart failure and premature aging in mice. But very little is known about the role of TFAM in cancer development. Here, we report the identification of frequent frameshift mutations in the coding mononucleotide repeat of <i>TFAM</i> in sporadic colorectal cancer (CRC) cell lines and in primary tumors with microsatellite instability (MSI), but not in microsatellite stable (MSS) CRC cell lines and tumors. The presence of the <i>TFAM</i> truncating mutation, in CRC cells with MSI, reduced the TFAM protein level <i>in vivo</i> and <i>in vitro</i> and correlated with mtDNA depletion. Furthermore, forced overexpression of wild-type TFAM in RKO cells carrying a <i>TFAM</i> truncating mutation suppressed cell proliferation and inhibited RKO cell-induced xenograft tumor growth. Moreover, these cells showed more susceptibility to cisplatin-induced apoptosis due to an increase of cytochrome <i>b</i> (Cyt <i>b</i>) expression and its release from mitochondria. An interaction assay between TFAM and the heavy-strand promoter (HSP) of mitochondria revealed that mutant TFAM exhibited reduced binding to HSP, leading to reduction in Cyt <i>b</i> transcription. Collectively, these data provide evidence that a high incidence of <i>TFAM</i> truncating mutations leads to mitochondrial copy number reduction and mitochondrial instability, distinguishing most CRC with MSI from MSS CRC. These mutations may play an important role in tumorigenesis and cisplatin-induced apoptotic resistance of most microsatellite-unstable CRCs. <i>Cancer Res; 71(8); 2978–87. ©2011 AACR</i>.</p></div>" @default.
• W4361241768 created "2023-03-31" @default.
• W4361241768 creator A5007562507 @default.
• W4361241768 creator A5007606729 @default.
• W4361241768 creator A5027681465 @default.
• W4361241768 creator A5049166738 @default.
• W4361241768 creator A5060335470 @default.
• W4361241768 creator A5073269968 @default.
• W4361241768 creator A5078143614 @default.
• W4361241768 creator A5084192942 @default.
• W4361241768 creator A5086141666 @default.
• W4361241768 creator A5090473173 @default.
• W4361241768 creator A5091784924 @default.
• W4361241768 date "2023-03-30" @default.
• W4361241768 modified "2023-09-29" @default.
• W4361241768 title "Data from Frequent Truncating Mutation of <i>TFAM</i> Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer" @default.
• W4361241768 doi "https://doi.org/10.1158/0008-5472.c.6502751" @default.
• W4361241768 hasPublicationYear "2023" @default.
• W4361241768 type Work @default.
• W4361241768 citedByCount "0" @default.
• W4361241768 crossrefType "posted-content" @default.
• W4361241768 hasAuthorship W4361241768A5007562507 @default.
• W4361241768 hasAuthorship W4361241768A5007606729 @default.
• W4361241768 hasAuthorship W4361241768A5027681465 @default.
• W4361241768 hasAuthorship W4361241768A5049166738 @default.
• W4361241768 hasAuthorship W4361241768A5060335470 @default.
• W4361241768 hasAuthorship W4361241768A5073269968 @default.
• W4361241768 hasAuthorship W4361241768A5078143614 @default.
• W4361241768 hasAuthorship W4361241768A5084192942 @default.
• W4361241768 hasAuthorship W4361241768A5086141666 @default.
• W4361241768 hasAuthorship W4361241768A5090473173 @default.
• W4361241768 hasAuthorship W4361241768A5091784924 @default.
• W4361241768 hasConcept C104317684 @default.
• W4361241768 hasConcept C153911025 @default.
• W4361241768 hasConcept C169415338 @default.
• W4361241768 hasConcept C190283241 @default.
• W4361241768 hasConcept C24586158 @default.
• W4361241768 hasConcept C502942594 @default.
• W4361241768 hasConcept C54355233 @default.
• W4361241768 hasConcept C86803240 @default.
• W4361241768 hasConceptScore W4361241768C104317684 @default.
• W4361241768 hasConceptScore W4361241768C153911025 @default.
• W4361241768 hasConceptScore W4361241768C169415338 @default.
• W4361241768 hasConceptScore W4361241768C190283241 @default.
• W4361241768 hasConceptScore W4361241768C24586158 @default.
• W4361241768 hasConceptScore W4361241768C502942594 @default.
• W4361241768 hasConceptScore W4361241768C54355233 @default.
• W4361241768 hasConceptScore W4361241768C86803240 @default.
• W4361241768 hasLocation W43612417681 @default.
• W4361241768 hasOpenAccess W4361241768 @default.
• W4361241768 hasPrimaryLocation W43612417681 @default.
• W4361241768 hasRelatedWork W1972275087 @default.
• W4361241768 hasRelatedWork W2019671050 @default.
• W4361241768 hasRelatedWork W2028339345 @default.
• W4361241768 hasRelatedWork W2168354816 @default.
• W4361241768 hasRelatedWork W2809940766 @default.
• W4361241768 hasRelatedWork W2947271275 @default.
• W4361241768 hasRelatedWork W4210674381 @default.
• W4361241768 hasRelatedWork W4318448161 @default.
• W4361241768 hasRelatedWork W4323294545 @default.
• W4361241768 hasRelatedWork W2183709724 @default.
• W4361241768 isParatext "false" @default.
• W4361241768 isRetracted "false" @default.
• W4361241768 workType "article" @default.