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- W4361242034 abstract "<div>Abstract<p>Fusion genes play important roles in tumorigenesis. The identification of the high-frequency <i>TMPRSS2</i> fusion with <i>ERG</i> and other <i>ETS</i> family genes in prostate cancer highlights the importance of fusion genes in solid tumor development and progression. However, the mechanisms leading to these fusions are unclear. We investigated whether androgen, through stimulating its receptor, could promote spatial genome reorganization and contribute to the generation of the <i>TMPRSS2:ERG</i> fusion. We show that treatment with androgen can induce the <i>TMPRSS2:ERG</i> fusion in both malignant and nonmalignant prostate epithelial cells. Although the fusion could be detected in malignant cells following 24-hour treatment, prolonged exposure to androgen was required to detect the fusion transcript in nonmalignant cells. We associated the fusion incidence with genetic factors, including androgen-induced gene proximity, androgen receptor exon1 CAG repeat length and expression of the <i>PIWIL1</i> gene. This study demonstrates that fusions can be induced prior to malignant transformation and generation of the fusion is associated with both gene proximity and loss of the ability to prevent double-strand breaks. <i>Cancer Res; 70(23); 9544–8. ©2010 AACR</i>.</p></div>" @default.
- W4361242034 created "2023-03-31" @default.
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- W4361242034 date "2023-03-30" @default.
- W4361242034 modified "2023-10-16" @default.
- W4361242034 title "Data from Androgen-Induced <i>TMPRSS2:ERG</i> Fusion in Nonmalignant Prostate Epithelial Cells" @default.
- W4361242034 doi "https://doi.org/10.1158/0008-5472.c.6501591" @default.
- W4361242034 hasPublicationYear "2023" @default.
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