Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361243669> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4361243669 abstract "<div>Abstract<p>Cyclin-dependent kinase 6 (CDK6) promotes cell cycle progression and is overexpressed in human lymphoid malignancies. To determine the role of CDK6 in development and tumorigenesis, we generated and analyzed knockout mice. <i>Cdk6</i>-deficient mice show pronounced thymic atrophy due to reduced proliferative fractions and concomitant transitional blocks in the double-negative stages. Using the OP9-DL1 system to deliver temporally controlled Notch receptor–dependent signaling, we show that CDK6 is required for Notch-dependent survival, proliferation, and differentiation. Furthermore, CDK6-deficient mice were resistant to lymphomagenesis induced by active Akt, a downstream target of Notch signaling. These results show a critical requirement for CDK6 in Notch/Akt-dependent T-cell development and tumorigenesis and strongly support CDK6 as a specific therapeutic target in human lymphoid malignancies. [Cancer Res 2009;69(3):810–8]</p></div>" @default.
- W4361243669 created "2023-03-31" @default.
- W4361243669 creator A5000634626 @default.
- W4361243669 creator A5018484566 @default.
- W4361243669 creator A5029414285 @default.
- W4361243669 creator A5036467169 @default.
- W4361243669 creator A5040097798 @default.
- W4361243669 creator A5041486255 @default.
- W4361243669 creator A5044831560 @default.
- W4361243669 creator A5050180985 @default.
- W4361243669 creator A5053708365 @default.
- W4361243669 creator A5057482532 @default.
- W4361243669 creator A5086035685 @default.
- W4361243669 creator A5088026481 @default.
- W4361243669 creator A5090059379 @default.
- W4361243669 date "2023-03-30" @default.
- W4361243669 modified "2023-10-14" @default.
- W4361243669 title "Data from A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis" @default.
- W4361243669 doi "https://doi.org/10.1158/0008-5472.c.6499448" @default.
- W4361243669 hasPublicationYear "2023" @default.
- W4361243669 type Work @default.
- W4361243669 citedByCount "0" @default.
- W4361243669 crossrefType "posted-content" @default.
- W4361243669 hasAuthorship W4361243669A5000634626 @default.
- W4361243669 hasAuthorship W4361243669A5018484566 @default.
- W4361243669 hasAuthorship W4361243669A5029414285 @default.
- W4361243669 hasAuthorship W4361243669A5036467169 @default.
- W4361243669 hasAuthorship W4361243669A5040097798 @default.
- W4361243669 hasAuthorship W4361243669A5041486255 @default.
- W4361243669 hasAuthorship W4361243669A5044831560 @default.
- W4361243669 hasAuthorship W4361243669A5050180985 @default.
- W4361243669 hasAuthorship W4361243669A5053708365 @default.
- W4361243669 hasAuthorship W4361243669A5057482532 @default.
- W4361243669 hasAuthorship W4361243669A5086035685 @default.
- W4361243669 hasAuthorship W4361243669A5088026481 @default.
- W4361243669 hasAuthorship W4361243669A5090059379 @default.
- W4361243669 hasConcept C11882975 @default.
- W4361243669 hasConcept C121608353 @default.
- W4361243669 hasConcept C124320809 @default.
- W4361243669 hasConcept C161879069 @default.
- W4361243669 hasConcept C184235292 @default.
- W4361243669 hasConcept C199649820 @default.
- W4361243669 hasConcept C203014093 @default.
- W4361243669 hasConcept C2776090121 @default.
- W4361243669 hasConcept C2778954852 @default.
- W4361243669 hasConcept C29537977 @default.
- W4361243669 hasConcept C502942594 @default.
- W4361243669 hasConcept C54355233 @default.
- W4361243669 hasConcept C555283112 @default.
- W4361243669 hasConcept C62478195 @default.
- W4361243669 hasConcept C75217442 @default.
- W4361243669 hasConcept C82495950 @default.
- W4361243669 hasConcept C86803240 @default.
- W4361243669 hasConcept C8891405 @default.
- W4361243669 hasConcept C95444343 @default.
- W4361243669 hasConcept C97029542 @default.
- W4361243669 hasConceptScore W4361243669C11882975 @default.
- W4361243669 hasConceptScore W4361243669C121608353 @default.
- W4361243669 hasConceptScore W4361243669C124320809 @default.
- W4361243669 hasConceptScore W4361243669C161879069 @default.
- W4361243669 hasConceptScore W4361243669C184235292 @default.
- W4361243669 hasConceptScore W4361243669C199649820 @default.
- W4361243669 hasConceptScore W4361243669C203014093 @default.
- W4361243669 hasConceptScore W4361243669C2776090121 @default.
- W4361243669 hasConceptScore W4361243669C2778954852 @default.
- W4361243669 hasConceptScore W4361243669C29537977 @default.
- W4361243669 hasConceptScore W4361243669C502942594 @default.
- W4361243669 hasConceptScore W4361243669C54355233 @default.
- W4361243669 hasConceptScore W4361243669C555283112 @default.
- W4361243669 hasConceptScore W4361243669C62478195 @default.
- W4361243669 hasConceptScore W4361243669C75217442 @default.
- W4361243669 hasConceptScore W4361243669C82495950 @default.
- W4361243669 hasConceptScore W4361243669C86803240 @default.
- W4361243669 hasConceptScore W4361243669C8891405 @default.
- W4361243669 hasConceptScore W4361243669C95444343 @default.
- W4361243669 hasConceptScore W4361243669C97029542 @default.
- W4361243669 hasLocation W43612436691 @default.
- W4361243669 hasOpenAccess W4361243669 @default.
- W4361243669 hasPrimaryLocation W43612436691 @default.
- W4361243669 hasRelatedWork W1593418262 @default.
- W4361243669 hasRelatedWork W2038720769 @default.
- W4361243669 hasRelatedWork W2082341926 @default.
- W4361243669 hasRelatedWork W2108559706 @default.
- W4361243669 hasRelatedWork W297761204 @default.
- W4361243669 hasRelatedWork W3019740916 @default.
- W4361243669 hasRelatedWork W3043645818 @default.
- W4361243669 hasRelatedWork W4243251494 @default.
- W4361243669 hasRelatedWork W4361239012 @default.
- W4361243669 hasRelatedWork W4361243669 @default.
- W4361243669 isParatext "false" @default.
- W4361243669 isRetracted "false" @default.
- W4361243669 workType "article" @default.