Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361243876> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4361243876 abstract "<div>Abstract<p>Several types of cancer cells, including colorectal cancer–derived cell lines, show austerity, the resistance to nutrient starvation, but exactly how cancer cells obtain energy sources under conditions in which their external nutrient supply is extremely limited remains to be clarified. Because autophagy is a catabolic process by which cells supply amino acids from self-digested organelles, cancer cells are likely to use autophagy to obtain amino acids as alternative energy sources. Amino acid deprivation-induced autophagy was assessed in DLD-1 and other colorectal cancer–derived cell lines. The autophagosome-incorporated LC3-II protein level increased after treatment with a combination of autolysosome inhibitors, which interferes with the consumption of autophagosomes. Autophagosome formation was also morphologically confirmed using ectopically expressed green fluorescent protein-LC3 fusion proteins in DLD-1 and SW480 cells. These data suggest that autophagosomes were actively produced and promptly consumed in colorectal cancer cells under nutrient starvation. Autolysosome inhibitors and 3-methyl adenine, which suppresses autophagosome formation, remarkably enhanced apoptosis under amino acid–deprived and glucose-deprived condition. Similar results were obtained in the cells with decreased ATG7 level by the RNA interference. These data suggest that autophagy is pivotal for the survival of colorectal cancer cells that have acquired austerity. Furthermore, autophagosome formation was seen only in the tumor cells but not in the adjacent noncancerous epithelial cells of colorectal cancer specimens. Taken together, autophagy is activated in colorectal cancers <i>in vitro</i> and <i>in vivo</i>, and autophagy may contribute to the survival of the cancer cells in their microenvironment. [Cancer Res 2007;67(20):9677–84]</p></div>" @default.
- W4361243876 created "2023-03-31" @default.
- W4361243876 creator A5003854379 @default.
- W4361243876 creator A5017586108 @default.
- W4361243876 creator A5028717780 @default.
- W4361243876 creator A5034012462 @default.
- W4361243876 creator A5038375140 @default.
- W4361243876 creator A5045694051 @default.
- W4361243876 creator A5062808952 @default.
- W4361243876 creator A5078003161 @default.
- W4361243876 creator A5090175609 @default.
- W4361243876 date "2023-03-30" @default.
- W4361243876 modified "2023-10-01" @default.
- W4361243876 title "Data from Autophagy Is Activated in Colorectal Cancer Cells and Contributes to the Tolerance to Nutrient Deprivation" @default.
- W4361243876 doi "https://doi.org/10.1158/0008-5472.c.6495746" @default.
- W4361243876 hasPublicationYear "2023" @default.
- W4361243876 type Work @default.
- W4361243876 citedByCount "0" @default.
- W4361243876 crossrefType "posted-content" @default.
- W4361243876 hasAuthorship W4361243876A5003854379 @default.
- W4361243876 hasAuthorship W4361243876A5017586108 @default.
- W4361243876 hasAuthorship W4361243876A5028717780 @default.
- W4361243876 hasAuthorship W4361243876A5034012462 @default.
- W4361243876 hasAuthorship W4361243876A5038375140 @default.
- W4361243876 hasAuthorship W4361243876A5045694051 @default.
- W4361243876 hasAuthorship W4361243876A5062808952 @default.
- W4361243876 hasAuthorship W4361243876A5078003161 @default.
- W4361243876 hasAuthorship W4361243876A5090175609 @default.
- W4361243876 hasConcept C121608353 @default.
- W4361243876 hasConcept C168296220 @default.
- W4361243876 hasConcept C185592680 @default.
- W4361243876 hasConcept C190283241 @default.
- W4361243876 hasConcept C203522944 @default.
- W4361243876 hasConcept C502942594 @default.
- W4361243876 hasConcept C526805850 @default.
- W4361243876 hasConcept C54355233 @default.
- W4361243876 hasConcept C55493867 @default.
- W4361243876 hasConcept C86803240 @default.
- W4361243876 hasConcept C95444343 @default.
- W4361243876 hasConcept C96232424 @default.
- W4361243876 hasConceptScore W4361243876C121608353 @default.
- W4361243876 hasConceptScore W4361243876C168296220 @default.
- W4361243876 hasConceptScore W4361243876C185592680 @default.
- W4361243876 hasConceptScore W4361243876C190283241 @default.
- W4361243876 hasConceptScore W4361243876C203522944 @default.
- W4361243876 hasConceptScore W4361243876C502942594 @default.
- W4361243876 hasConceptScore W4361243876C526805850 @default.
- W4361243876 hasConceptScore W4361243876C54355233 @default.
- W4361243876 hasConceptScore W4361243876C55493867 @default.
- W4361243876 hasConceptScore W4361243876C86803240 @default.
- W4361243876 hasConceptScore W4361243876C95444343 @default.
- W4361243876 hasConceptScore W4361243876C96232424 @default.
- W4361243876 hasLocation W43612438761 @default.
- W4361243876 hasOpenAccess W4361243876 @default.
- W4361243876 hasPrimaryLocation W43612438761 @default.
- W4361243876 hasRelatedWork W1987467930 @default.
- W4361243876 hasRelatedWork W1992832446 @default.
- W4361243876 hasRelatedWork W2056478340 @default.
- W4361243876 hasRelatedWork W2145822917 @default.
- W4361243876 hasRelatedWork W2468193431 @default.
- W4361243876 hasRelatedWork W2512384325 @default.
- W4361243876 hasRelatedWork W2957721022 @default.
- W4361243876 hasRelatedWork W2962756305 @default.
- W4361243876 hasRelatedWork W4289874706 @default.
- W4361243876 hasRelatedWork W4367312761 @default.
- W4361243876 isParatext "false" @default.
- W4361243876 isRetracted "false" @default.
- W4361243876 workType "article" @default.