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• W4361244097 abstract "<div>Abstract<p>The RNA-specific cytidine deaminase apobec-1 is an AU-rich RNA binding protein that binds the 3′ untranslated region (UTR) of cyclooxygenase-2 (Cox-2) mRNA and stabilizes its turnover <i>in vitro</i>. Cox-2 overexpression accompanies intestinal adenoma formation in both humans and mice. Evidence from both genetic deletion studies as well as from pharmacologic inhibition has implicated Cox-2 in the development of intestinal adenomas in experimental animals and in adenomas and colorectal cancer in humans. Here, we show that small intestinal adenoma formation is dramatically reduced in compound <i>Apc^min/+</i> <i>apobec-1</i>^−/− mice when compared with the parental <i>Apc^min/+</i> strain. This reduced tumor burden was found in association with increased small intestinal apoptosis and reduced proliferation in small intestinal crypt-villus units from compound <i>Apc^min/+</i> <i>apobec-1</i>^−/− mice. Intestinal adenomas from compound <i>Apc^min/+</i> <i>apobec-1</i>^−/− mice showed a <2-fold increase in Cox-2 mRNA abundance and reduced prostaglandin E₂ content compared with adenomas from the parental <i>Apc^min/+</i> strain. In addition, there was reduced expression in adenomas from compound <i>Apc^min/+</i> <i>apobec-1</i>^−/− mice of other mRNAs (including epidermal growth factor receptor, peroxisome proliferator–activated receptor δ, prostaglandin receptor EP4, and c-myc), each containing the apobec-1 consensus binding site within their 3′-UTR. Adenovirus-mediated apobec-1 introduction into HCA-7 (colorectal cancer) cells showed a dose-dependent increase in Cox-2 protein and stabilization of endogenous Cox-2 mRNA. These findings suggest that deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation. [Cancer Res 2007;67(18):8565–73]</p></div>" @default.
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• W4361244097 date "2023-03-30" @default.
• W4361244097 modified "2023-09-26" @default.
• W4361244097 title "Data from Deletion of the AU-Rich RNA Binding Protein Apobec-1 Reduces Intestinal Tumor Burden in <i>Apc^min</i> Mice" @default.
• W4361244097 doi "https://doi.org/10.1158/0008-5472.c.6495918" @default.
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