Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361245162> ?p ?o ?g. }
- W4361245162 endingPage "385" @default.
- W4361245162 startingPage "376" @default.
- W4361245162 abstract "Abstract Aims Routine revascularization in patients with ST-segment elevation myocardial infarction (STEMI) presenting >48 h after symptom onset is not recommended. Methods and results We compared outcomes of STEMI patients undergoing percutaneous coronary intervention (PCI) according to total ischaemic time. Patients included in the Bern-PCI registry and the Multicenter Special Program University Medicine ACS (SPUM-ACS) between 2009 and 2019 were analysed. Based on symptom-to-balloon-time, patients were categorized as early (<12 h), late (12–48 h), or very late presenters (>48 h). Co-primary endpoints were all-cause mortality and target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization at 1 year. Of 6589 STEMI patients undergoing PCI, 73.9% were early, 17.2% late, and 8.9% very late presenters. The mean age was 63.4 years, and 22% were female. At 1 year, all-cause mortality occurred more frequently in late vs. early [5.8 vs. 4.4%, hazard ratio (HR) 1.34, 95% confidence interval (CI) 1.01–1.78, P = 0.04] and very late (6.8%) vs. early presenters (HR 1.59, 95% CI 1.12–2.25, P < 0.01). There was no excess in mortality comparing very late and late presenters (HR 1.18, 95% CI 0.79–1.77, P = 0.42). Target lesion failure was more frequent in late vs. early (8.3 vs. 6.5%, HR 1.29, 95% CI 1.02–1.63, P = 0.04) and very late (9.4%) vs. early presenters (HR 1.47, 95% CI 1.09–1.97, P = 0.01), and similar between very late and late presenters (HR 1.14, 95% CI 0.81–1.60, P = 0.46). Following adjustment, heart failure, impaired renal function, and previous gastrointestinal bleeding, but not treatment delay, were the main drivers of outcomes. Conclusion PCI >12 h after symptom onset was associated with less favourable outcomes, but very late vs. late presenters did not have an excess in events. While benefits seem uncertain, (very) late PCI appeared safe." @default.
- W4361245162 created "2023-03-31" @default.
- W4361245162 creator A5003278758 @default.
- W4361245162 creator A5004142072 @default.
- W4361245162 creator A5010599286 @default.
- W4361245162 creator A5019587141 @default.
- W4361245162 creator A5028632973 @default.
- W4361245162 creator A5031656295 @default.
- W4361245162 creator A5040134218 @default.
- W4361245162 creator A5040563213 @default.
- W4361245162 creator A5045293936 @default.
- W4361245162 creator A5051530432 @default.
- W4361245162 creator A5060467171 @default.
- W4361245162 creator A5061359562 @default.
- W4361245162 creator A5075035084 @default.
- W4361245162 creator A5081653127 @default.
- W4361245162 creator A5083917493 @default.
- W4361245162 creator A5085573148 @default.
- W4361245162 creator A5088669182 @default.
- W4361245162 creator A5089537011 @default.
- W4361245162 date "2023-03-30" @default.
- W4361245162 modified "2023-10-11" @default.
- W4361245162 title "Clinical outcomes in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary interventions later than 48 h after symptom onset" @default.
- W4361245162 cites W111204299 @default.
- W4361245162 cites W1582971617 @default.
- W4361245162 cites W1973740559 @default.
- W4361245162 cites W1994368506 @default.
- W4361245162 cites W2018018904 @default.
- W4361245162 cites W2050703343 @default.
- W4361245162 cites W2052398654 @default.
- W4361245162 cites W2094494009 @default.
- W4361245162 cites W2103707733 @default.
- W4361245162 cites W2108512082 @default.
- W4361245162 cites W2113698123 @default.
- W4361245162 cites W2114392716 @default.
- W4361245162 cites W2117809414 @default.
- W4361245162 cites W2140501627 @default.
- W4361245162 cites W2146912479 @default.
- W4361245162 cites W2148910374 @default.
- W4361245162 cites W2154421193 @default.
- W4361245162 cites W2156752738 @default.
- W4361245162 cites W2159159954 @default.
- W4361245162 cites W2166950143 @default.
- W4361245162 cites W2169387542 @default.
- W4361245162 cites W2327670413 @default.
- W4361245162 cites W2607645430 @default.
- W4361245162 cites W2754054868 @default.
- W4361245162 cites W2798078275 @default.
- W4361245162 cites W2890544474 @default.
- W4361245162 cites W2953536778 @default.
- W4361245162 cites W2970737263 @default.
- W4361245162 cites W2989011219 @default.
- W4361245162 cites W2999854791 @default.
- W4361245162 cites W3010954149 @default.
- W4361245162 cites W3040668198 @default.
- W4361245162 cites W3127581834 @default.
- W4361245162 cites W3160932520 @default.
- W4361245162 cites W3183857127 @default.
- W4361245162 cites W3186577452 @default.
- W4361245162 cites W3193598686 @default.
- W4361245162 cites W3201386644 @default.
- W4361245162 cites W3208532926 @default.
- W4361245162 cites W3211658997 @default.
- W4361245162 cites W3217576295 @default.
- W4361245162 cites W4200601666 @default.
- W4361245162 cites W4210431983 @default.
- W4361245162 cites W4236531408 @default.
- W4361245162 cites W4293364542 @default.
- W4361245162 cites W4376595456 @default.
- W4361245162 cites W584804003 @default.
- W4361245162 doi "https://doi.org/10.1093/ehjacc/zuad033" @default.
- W4361245162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36996409" @default.
- W4361245162 hasPublicationYear "2023" @default.
- W4361245162 type Work @default.
- W4361245162 citedByCount "0" @default.
- W4361245162 crossrefType "journal-article" @default.
- W4361245162 hasAuthorship W4361245162A5003278758 @default.
- W4361245162 hasAuthorship W4361245162A5004142072 @default.
- W4361245162 hasAuthorship W4361245162A5010599286 @default.
- W4361245162 hasAuthorship W4361245162A5019587141 @default.
- W4361245162 hasAuthorship W4361245162A5028632973 @default.
- W4361245162 hasAuthorship W4361245162A5031656295 @default.
- W4361245162 hasAuthorship W4361245162A5040134218 @default.
- W4361245162 hasAuthorship W4361245162A5040563213 @default.
- W4361245162 hasAuthorship W4361245162A5045293936 @default.
- W4361245162 hasAuthorship W4361245162A5051530432 @default.
- W4361245162 hasAuthorship W4361245162A5060467171 @default.
- W4361245162 hasAuthorship W4361245162A5061359562 @default.
- W4361245162 hasAuthorship W4361245162A5075035084 @default.
- W4361245162 hasAuthorship W4361245162A5081653127 @default.
- W4361245162 hasAuthorship W4361245162A5083917493 @default.
- W4361245162 hasAuthorship W4361245162A5085573148 @default.
- W4361245162 hasAuthorship W4361245162A5088669182 @default.
- W4361245162 hasAuthorship W4361245162A5089537011 @default.
- W4361245162 hasConcept C126322002 @default.
- W4361245162 hasConcept C141071460 @default.
- W4361245162 hasConcept C164705383 @default.
- W4361245162 hasConcept C207103383 @default.