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- W4361252504 abstract "<div>Abstract<p>Tumor cells often become resistant to DNA damage–based therapy; however, the underlying mechanisms are not yet understood. Here, we show that tumor cells exposed to DNA damage counteract cell death by releasing the antiapoptotic protein, survivin, from mitochondria. This is independent of p53, and requires activated checkpoint kinase 2 (Chk2), a putative tumor suppressor. Molecular or genetic targeting of Chk2 prevents the release of survivin from mitochondria, enhances DNA damage–induced tumor cell apoptosis, and inhibits the growth of resistant <i>in vivo</i> tumors. Therefore, activated Chk2 circumvents its own tumor-suppressive functions by promoting tumor cell survival. Inhibiting Chk2 in combination with DNA-damaging agents may provide a rational approach for treating resistant tumors. (Cancer Res 2006; 66(24): 11576-9)</p></div>" @default.
- W4361252504 created "2023-03-31" @default.
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- W4361252504 date "2023-03-30" @default.
- W4361252504 modified "2023-10-18" @default.
- W4361252504 title "Data from Activated Checkpoint Kinase 2 Provides a Survival Signal for Tumor Cells" @default.
- W4361252504 doi "https://doi.org/10.1158/0008-5472.c.6494864" @default.
- W4361252504 hasPublicationYear "2023" @default.
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