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- W4361253072 abstract "<div>Abstract<p>Adenocarcinoma cells from the pleural effusion of a patient with breast cancer were injected into the mammary glands of nude mice and grown into solid tumors. A cell line derived from these tumors expressed α-smooth muscle actin but not human cytokeratin 7, indicating “activated” stroma of mouse origin. Cells in mitosis exhibited mainly polyploid mouse karyotypes, but 30% had mixed mouse and human chromosomes, among which 8% carried mouse/human translocations. Nuclei of interphase cells were 64% hybrid. Hybrid mouse/human nuclei were also detected in the primary xenograft. Thus, synkaryons formed in the solid tumor by spontaneous fusion between the malignant human epithelium and the surrounding normal host mouse stroma. The transformed stroma-derived cells are tumorigenic with histopathologic features of malignancy, suggesting a new mechanism for tumor progression. (Cancer Res 2006; 66(16): 8274-9)</p></div>" @default.
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- W4361253072 date "2023-03-30" @default.
- W4361253072 modified "2023-09-27" @default.
- W4361253072 title "Data from Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium" @default.
- W4361253072 doi "https://doi.org/10.1158/0008-5472.c.6494702" @default.
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