Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361253670> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4361253670 abstract "<div>Abstract<p>The tumor suppressor protein p53 is a transcription factor that induces G<sub>1</sub> arrest of the cell cycle and/or apoptosis. The murine double-minute protein MDM2 and its homologue MDM4 (also known as <i>MDMX</i>) are critical regulators of p53. Altered transcripts of the human homologue of <i>mdm2, MDM2</i>, have been identified in human tumors, such as invasive carcinoma of the breast, lung carcinoma, and liposarcoma. MDM2 alternate forms act to negatively regulate the normal <i>MDM2</i> gene product, thus activating p53. Although many reports have documented a plethora of tumor types characterized by <i>MDM2</i> alternative transcripts, few have investigated the signals that might initiate alternative splicing. We have identified a novel role of these alternative <i>MDM2</i> transcripts in the normal surveillance mechanism of the cell and in DNA damage response. We report that alternate forms of <i>MDM2</i> are detected after UV irradiation. Furthermore, we show that mouse cells treated with UV are also characterized by alternative transcripts of <i>mdm2</i>, suggesting that this is an important and evolutionarily conserved mechanism for regulating the expression of <i>MDM2/mdm2</i>. An additional p53 regulator and <i>mdm2</i> family member, <i>MDM4</i>, is likewise alternatively spliced following UV irradiation. By activating alternative splicing of both <i>MDM2</i> and <i>MDM4</i>, yet another layer of p53 regulation is initiated by the cells in response to damage. A stepwise model for malignant conversion by which alternate forms of MDM2 and MDM4 place selective pressure on the cells to acquire additional alterations in the p53 pathway is herein proposed. (Cancer Res 2006; 66(19): 9502-8)</p></div>" @default.
- W4361253670 created "2023-03-31" @default.
- W4361253670 creator A5006365668 @default.
- W4361253670 creator A5013974839 @default.
- W4361253670 creator A5049926943 @default.
- W4361253670 creator A5070220648 @default.
- W4361253670 creator A5076622040 @default.
- W4361253670 date "2023-03-30" @default.
- W4361253670 modified "2023-09-30" @default.
- W4361253670 title "Data from Genotoxic Stress Induces Coordinately Regulated Alternative Splicing of the p53 Modulators MDM2 and MDM4" @default.
- W4361253670 doi "https://doi.org/10.1158/0008-5472.c.6494388.v1" @default.
- W4361253670 hasPublicationYear "2023" @default.
- W4361253670 type Work @default.
- W4361253670 citedByCount "0" @default.
- W4361253670 crossrefType "posted-content" @default.
- W4361253670 hasAuthorship W4361253670A5006365668 @default.
- W4361253670 hasAuthorship W4361253670A5013974839 @default.
- W4361253670 hasAuthorship W4361253670A5049926943 @default.
- W4361253670 hasAuthorship W4361253670A5070220648 @default.
- W4361253670 hasAuthorship W4361253670A5076622040 @default.
- W4361253670 hasConcept C104317684 @default.
- W4361253670 hasConcept C143425029 @default.
- W4361253670 hasConcept C153911025 @default.
- W4361253670 hasConcept C190283241 @default.
- W4361253670 hasConcept C194583182 @default.
- W4361253670 hasConcept C2776192174 @default.
- W4361253670 hasConcept C2777221213 @default.
- W4361253670 hasConcept C36823959 @default.
- W4361253670 hasConcept C502942594 @default.
- W4361253670 hasConcept C54355233 @default.
- W4361253670 hasConcept C552990157 @default.
- W4361253670 hasConcept C86803240 @default.
- W4361253670 hasConceptScore W4361253670C104317684 @default.
- W4361253670 hasConceptScore W4361253670C143425029 @default.
- W4361253670 hasConceptScore W4361253670C153911025 @default.
- W4361253670 hasConceptScore W4361253670C190283241 @default.
- W4361253670 hasConceptScore W4361253670C194583182 @default.
- W4361253670 hasConceptScore W4361253670C2776192174 @default.
- W4361253670 hasConceptScore W4361253670C2777221213 @default.
- W4361253670 hasConceptScore W4361253670C36823959 @default.
- W4361253670 hasConceptScore W4361253670C502942594 @default.
- W4361253670 hasConceptScore W4361253670C54355233 @default.
- W4361253670 hasConceptScore W4361253670C552990157 @default.
- W4361253670 hasConceptScore W4361253670C86803240 @default.
- W4361253670 hasLocation W43612536701 @default.
- W4361253670 hasOpenAccess W4361253670 @default.
- W4361253670 hasPrimaryLocation W43612536701 @default.
- W4361253670 hasRelatedWork W2007597782 @default.
- W4361253670 hasRelatedWork W2046302208 @default.
- W4361253670 hasRelatedWork W2115078294 @default.
- W4361253670 hasRelatedWork W2315935406 @default.
- W4361253670 hasRelatedWork W2335003908 @default.
- W4361253670 hasRelatedWork W2778670988 @default.
- W4361253670 hasRelatedWork W2885201285 @default.
- W4361253670 hasRelatedWork W3162856593 @default.
- W4361253670 hasRelatedWork W3182820818 @default.
- W4361253670 hasRelatedWork W4282976804 @default.
- W4361253670 isParatext "false" @default.
- W4361253670 isRetracted "false" @default.
- W4361253670 workType "article" @default.