Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361254321> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4361254321 abstract "<div>Abstract<p>Pituitary adenomas comprise 10% of intracranial tumors and occur in about 20% of the population. They cause significant morbidity by compression of regional structures or the inappropriate expression of pituitary hormones. Their molecular pathogenesis is unclear, and the current classification of clinically nonfunctional tumors does not reflect any molecular distinctions between the subtypes. To further elucidate the molecular changes that contribute to the development of these tumors and reclassify them according to the molecular basis, we investigated 11 nonfunctional pituitary adenomas and eight normal pituitary glands, using 33 oligonucleotide GeneChip microarrays. We validated microarray results with the reverse transcription real-time quantitative PCR, using a larger number of nonfunctional adenomas. We also used proteomic analysis to examine protein expression in these nonfunctional adenomas. Microarray analysis identified significant increases in the expression of 115 genes and decreases in 169 genes, whereas proteomic analysis identified 21 up-regulated and 29 down-regulated proteins. We observed changes in expression of SFRP1, TLE2, PITX2, NOTCH3, and DLK1, suggesting that the developmental Wnt and Notch pathways are activated and important for the progression of nonfunctional pituitary adenomas. We further analyzed gene expression profiles of all nonfunctional pituitary subtypes to each other and identified genes that were affected uniquely in each subtype. These results show distinct gene and protein expression patterns in adenomas, provide new insight into the pathogenesis and molecular classification of nonfunctional pituitary adenomas, and suggest that therapeutic targeting of the Notch pathway could be effective for these tumors.</p></div>" @default.
- W4361254321 created "2023-03-31" @default.
- W4361254321 creator A5014615941 @default.
- W4361254321 creator A5035705346 @default.
- W4361254321 creator A5059197448 @default.
- W4361254321 creator A5073229744 @default.
- W4361254321 creator A5089111144 @default.
- W4361254321 creator A5091679209 @default.
- W4361254321 date "2023-03-30" @default.
- W4361254321 modified "2023-09-30" @default.
- W4361254321 title "Data from Novel Molecular Signaling and Classification of Human Clinically Nonfunctional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses" @default.
- W4361254321 doi "https://doi.org/10.1158/0008-5472.c.6494214" @default.
- W4361254321 hasPublicationYear "2023" @default.
- W4361254321 type Work @default.
- W4361254321 citedByCount "0" @default.
- W4361254321 crossrefType "posted-content" @default.
- W4361254321 hasAuthorship W4361254321A5014615941 @default.
- W4361254321 hasAuthorship W4361254321A5035705346 @default.
- W4361254321 hasAuthorship W4361254321A5059197448 @default.
- W4361254321 hasAuthorship W4361254321A5073229744 @default.
- W4361254321 hasAuthorship W4361254321A5089111144 @default.
- W4361254321 hasAuthorship W4361254321A5091679209 @default.
- W4361254321 hasConcept C104317684 @default.
- W4361254321 hasConcept C137620995 @default.
- W4361254321 hasConcept C150194340 @default.
- W4361254321 hasConcept C18431079 @default.
- W4361254321 hasConcept C186836561 @default.
- W4361254321 hasConcept C203014093 @default.
- W4361254321 hasConcept C2777428134 @default.
- W4361254321 hasConcept C2779318953 @default.
- W4361254321 hasConcept C2780942790 @default.
- W4361254321 hasConcept C502942594 @default.
- W4361254321 hasConcept C54355233 @default.
- W4361254321 hasConcept C8415881 @default.
- W4361254321 hasConcept C86803240 @default.
- W4361254321 hasConcept C95371953 @default.
- W4361254321 hasConceptScore W4361254321C104317684 @default.
- W4361254321 hasConceptScore W4361254321C137620995 @default.
- W4361254321 hasConceptScore W4361254321C150194340 @default.
- W4361254321 hasConceptScore W4361254321C18431079 @default.
- W4361254321 hasConceptScore W4361254321C186836561 @default.
- W4361254321 hasConceptScore W4361254321C203014093 @default.
- W4361254321 hasConceptScore W4361254321C2777428134 @default.
- W4361254321 hasConceptScore W4361254321C2779318953 @default.
- W4361254321 hasConceptScore W4361254321C2780942790 @default.
- W4361254321 hasConceptScore W4361254321C502942594 @default.
- W4361254321 hasConceptScore W4361254321C54355233 @default.
- W4361254321 hasConceptScore W4361254321C8415881 @default.
- W4361254321 hasConceptScore W4361254321C86803240 @default.
- W4361254321 hasConceptScore W4361254321C95371953 @default.
- W4361254321 hasLocation W43612543211 @default.
- W4361254321 hasOpenAccess W4361254321 @default.
- W4361254321 hasPrimaryLocation W43612543211 @default.
- W4361254321 hasRelatedWork W1531528770 @default.
- W4361254321 hasRelatedWork W1983994322 @default.
- W4361254321 hasRelatedWork W2006024165 @default.
- W4361254321 hasRelatedWork W2053053668 @default.
- W4361254321 hasRelatedWork W2117264420 @default.
- W4361254321 hasRelatedWork W2415025170 @default.
- W4361254321 hasRelatedWork W2900947575 @default.
- W4361254321 hasRelatedWork W2998765584 @default.
- W4361254321 hasRelatedWork W3032874291 @default.
- W4361254321 hasRelatedWork W74695042 @default.
- W4361254321 isParatext "false" @default.
- W4361254321 isRetracted "false" @default.
- W4361254321 workType "article" @default.