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- W4361254402 abstract "Dental caries is an infectious disease that is a major concern for dentists. Streptococci and Lactobacilli were long thought to be the primary etiology responsible for caries. Candida albicans with acidogenic and aciduric characteristics has recently been implicated in the onset and progression of cariogenic lesions. Moreover, due to the increased resistance to common antimicrobials, the discovery of innovative candidates is in high demand. Therefore, our study might be the first report that explores the efficacy of glass ionomer cement (GIC) incorporated with a newly modified carboxylated chitosan derivative (CS-MC) against multidrug-resistant (MDR) and/or pandrug resistant (PDR) C. albicans isolated from the oral cavity. In this work, four CS-MC-GIC groups with different concentrations were formulated. Group four (CS-MC-GIC-4) gave a significant performance as an anticandidal agent against selected PDR Candida strain, with an obvious decrease in its cell viability and high antibiofilm activity. It also, enhanced all the mechanical properties and supports cell viability of Vero cells as a nontoxic compound. Moreover, CS-MC-GIC-4 inhibited neuraminidases completely, which might provide a novel mechanism to prevent dental/oral infections. Thus, findings in this study open up new prospect of the utilization of CS-MC-GIC as a novel dental filling material against oral drug-resistant Candida." @default.
- W4361254402 created "2023-03-31" @default.
- W4361254402 creator A5003496821 @default.
- W4361254402 creator A5006206093 @default.
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- W4361254402 creator A5029512122 @default.
- W4361254402 creator A5053435309 @default.
- W4361254402 creator A5053665490 @default.
- W4361254402 date "2023-03-30" @default.
- W4361254402 modified "2023-10-18" @default.
- W4361254402 title "Exploring the biomedical potential of a novel modified glass ionomer cement against the pandrug-resistant oral pathogen <i>Candida albicans</i> SYN-01" @default.
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