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- W4361254563 abstract "<div>Abstract<p>Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of <i>FGFR3</i> mutations and chromosome 9 alterations. High-grade and muscle-invasive tumors are characterized by <i>Tp53</i> mutations and aneuploidy. We have analyzed the sequence of exons 9 and 20 of <i>PIK3CA</i> in a panel of bladder tumors covering the whole spectrum of the disease. DNA from formalin-fixed, paraffin-embedded tumor sections was amplified by PCR and products were sequenced. In an unselected panel of tumors representative of the disease, the <i>PIK3CA</i> mutation prevalence was 13% (11 of 87). Mutations occurred mainly at the previously identified hotspots (codons 542, 545, 1007, and 1047). The distribution according to stage was as follows: papillary urothelial neoplasms of uncertain malignant potential (PUNLMP; 11 of 43, 25.6%), T<sub>a</sub> (9 of 57, 16%), T<sub>1</sub> (2 of 10, 20%), and muscle-invasive tumors (0 of 20, 0%; <i>P</i> = 0.019). Mutations were associated with low-grade tumors: grade 1 (6 of 27, 22.2%), grade 2 (3 of 23, 13%), and grade 3 (2 of 37, 5.4%; <i>P</i> = 0.047). Overall, <i>PIK3CA</i> mutations were strongly associated with <i>FGFR3</i> mutations: 18 of 69 (26%) <i>FGFR3<sup>mut</sup></i> tumors were <i>PIK3CA<sup>mut</sup></i>, versus 4 of 58 (6.9%) <i>FGFR3<sup>wt</sup></i> tumors (<i>P</i> = 0.005). Our findings indicate that <i>PIK3CA</i> mutations are a common event that can occur early in bladder carcinogenesis and support the notion that papillary and muscle-invasive tumors arise through different molecular pathways. PIK3CA may constitute a novel diagnostic and prognostic tool, as well as a therapeutic target, in bladder cancer. (Cancer Res 2006; 66(15): 7401-4)</p></div>" @default.
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- W4361254563 date "2023-03-30" @default.
- W4361254563 modified "2023-09-26" @default.
- W4361254563 title "Data from <i>PIK3CA</i> Mutations Are an Early Genetic Alteration Associated with <i>FGFR3</i> Mutations in Superficial Papillary Bladder Tumors" @default.
- W4361254563 doi "https://doi.org/10.1158/0008-5472.c.6494190.v1" @default.
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