Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361255092> ?p ?o ?g. }
- W4361255092 abstract "SUMMARY Metabolic reprogramming in response to infection plays a critical role for septic survival. During a septic episode, the heart heavily relies on hepatic lipid particles to prevent heart damage and failure. Inositol- Requiring Enzyme 1 (IRE1) is the most conserved unfolded protein response (UPR) regulator that governs homeostasis of the endoplasmic reticulum (ER), the major site for lipid synthesis and processing. Here we show that hepatocyte IRE1 is indispensable for protecting against septic mortality in two different rodent models of experimental sepsis. The protective effect of hepatic IRE1 was not attributed to the inflammatory response since hepatic IRE1 deletion did not alter hepatic or systemic cytokine response. However, loss of IRE1 in the liver significantly augmented septic cardiac dysfunction in part due to a skewed immune-metabolic balance. Lipidomic and metabolomic analyses further revealed that loss of IRE1 in the liver compromised adaptive intrahepatic and circulating lipid reprogramming, including VLDL, in response to septic challenge. Furthermore, we identified that the protective effects against septic mortality are mediated by a non-canonical IRE1-dependent mechanism. Together, our study provides the first insight into how a disruption of hepatic ER-mediated lipid metabolic regulation promotes sepsis-associated cardiac immuno-metabolic imbalance." @default.
- W4361255092 created "2023-03-31" @default.
- W4361255092 creator A5006982292 @default.
- W4361255092 creator A5014130007 @default.
- W4361255092 creator A5019036513 @default.
- W4361255092 creator A5027631939 @default.
- W4361255092 creator A5030399047 @default.
- W4361255092 creator A5033821392 @default.
- W4361255092 creator A5043424791 @default.
- W4361255092 creator A5045371886 @default.
- W4361255092 creator A5047406643 @default.
- W4361255092 creator A5058481769 @default.
- W4361255092 creator A5076681768 @default.
- W4361255092 creator A5079867682 @default.
- W4361255092 creator A5090796277 @default.
- W4361255092 date "2023-03-15" @default.
- W4361255092 modified "2023-10-16" @default.
- W4361255092 title "Hepatic IRE1 Protects Against Septic Cardiac Failure" @default.
- W4361255092 cites W1893143839 @default.
- W4361255092 cites W1960422292 @default.
- W4361255092 cites W1964443702 @default.
- W4361255092 cites W1987157247 @default.
- W4361255092 cites W1993688639 @default.
- W4361255092 cites W1994446230 @default.
- W4361255092 cites W1995044262 @default.
- W4361255092 cites W2029175756 @default.
- W4361255092 cites W2029619625 @default.
- W4361255092 cites W2036468160 @default.
- W4361255092 cites W2043931994 @default.
- W4361255092 cites W2046449500 @default.
- W4361255092 cites W2057979643 @default.
- W4361255092 cites W2058949884 @default.
- W4361255092 cites W2060122053 @default.
- W4361255092 cites W2060267424 @default.
- W4361255092 cites W2065612971 @default.
- W4361255092 cites W2067082060 @default.
- W4361255092 cites W2090556647 @default.
- W4361255092 cites W2097310310 @default.
- W4361255092 cites W2107401866 @default.
- W4361255092 cites W2122345674 @default.
- W4361255092 cites W2124925985 @default.
- W4361255092 cites W2144589352 @default.
- W4361255092 cites W2155377124 @default.
- W4361255092 cites W2167376541 @default.
- W4361255092 cites W2268800856 @default.
- W4361255092 cites W2280404143 @default.
- W4361255092 cites W2327796497 @default.
- W4361255092 cites W2405485021 @default.
- W4361255092 cites W2407944073 @default.
- W4361255092 cites W2513994159 @default.
- W4361255092 cites W2567040191 @default.
- W4361255092 cites W2597551603 @default.
- W4361255092 cites W2623612217 @default.
- W4361255092 cites W2626179297 @default.
- W4361255092 cites W2793448338 @default.
- W4361255092 cites W2793503814 @default.
- W4361255092 cites W2795639367 @default.
- W4361255092 cites W2803942685 @default.
- W4361255092 cites W2823725159 @default.
- W4361255092 cites W2909958736 @default.
- W4361255092 cites W2946237195 @default.
- W4361255092 cites W2967524380 @default.
- W4361255092 cites W2982594794 @default.
- W4361255092 cites W3000361032 @default.
- W4361255092 cites W3003281746 @default.
- W4361255092 cites W3005962423 @default.
- W4361255092 cites W3030834164 @default.
- W4361255092 cites W3037147139 @default.
- W4361255092 cites W3045689662 @default.
- W4361255092 cites W3049066481 @default.
- W4361255092 cites W3108396239 @default.
- W4361255092 cites W3121798646 @default.
- W4361255092 cites W3131971418 @default.
- W4361255092 cites W3176369796 @default.
- W4361255092 cites W3185427430 @default.
- W4361255092 cites W4244560772 @default.
- W4361255092 cites W4283801635 @default.
- W4361255092 cites W4287378939 @default.
- W4361255092 cites W4315779391 @default.
- W4361255092 doi "https://doi.org/10.1101/2023.03.14.532202" @default.
- W4361255092 hasPublicationYear "2023" @default.
- W4361255092 type Work @default.
- W4361255092 citedByCount "0" @default.
- W4361255092 crossrefType "posted-content" @default.
- W4361255092 hasAuthorship W4361255092A5006982292 @default.
- W4361255092 hasAuthorship W4361255092A5014130007 @default.
- W4361255092 hasAuthorship W4361255092A5019036513 @default.
- W4361255092 hasAuthorship W4361255092A5027631939 @default.
- W4361255092 hasAuthorship W4361255092A5030399047 @default.
- W4361255092 hasAuthorship W4361255092A5033821392 @default.
- W4361255092 hasAuthorship W4361255092A5043424791 @default.
- W4361255092 hasAuthorship W4361255092A5045371886 @default.
- W4361255092 hasAuthorship W4361255092A5047406643 @default.
- W4361255092 hasAuthorship W4361255092A5058481769 @default.
- W4361255092 hasAuthorship W4361255092A5076681768 @default.
- W4361255092 hasAuthorship W4361255092A5079867682 @default.
- W4361255092 hasAuthorship W4361255092A5090796277 @default.
- W4361255092 hasBestOaLocation W43612550921 @default.
- W4361255092 hasConcept C126322002 @default.
- W4361255092 hasConcept C134018914 @default.