Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361255955> ?p ?o ?g. }
- W4361255955 endingPage "112323" @default.
- W4361255955 startingPage "112323" @default.
- W4361255955 abstract "Special AT-rich sequence binding protein 1 (SATB1) has long been proposed to act as a global chromatin loop organizer in T cells. However, the exact functions of SATB1 in spatial genome organization remain elusive. Here we show that the depletion of SATB1 in human and murine T cells leads to transcriptional dysregulation for genes involved in T cell activation, as well as alterations of 3D genome architecture at multiple levels, including compartments, topologically associating domains, and loops. Importantly, SATB1 extensively colocalizes with CTCF throughout the genome. Depletion of SATB1 leads to increased chromatin contacts among and across the SATB1/CTCF co-occupied sites, thereby affecting the transcription of critical regulators of T cell activation. The loss of SATB1 does not affect CTCF occupancy but significantly reduces the retention of CTCF in the nuclear matrix. Collectively, our data show that SATB1 contributes to 3D genome organization by constraining chromatin topology surrounding CTCF-binding sites." @default.
- W4361255955 created "2023-03-31" @default.
- W4361255955 creator A5012207911 @default.
- W4361255955 creator A5036026030 @default.
- W4361255955 creator A5063923189 @default.
- W4361255955 date "2023-04-01" @default.
- W4361255955 modified "2023-10-16" @default.
- W4361255955 title "SATB1 regulates 3D genome architecture in T cells by constraining chromatin interactions surrounding CTCF-binding sites" @default.
- W4361255955 cites W1831401007 @default.
- W4361255955 cites W1941076503 @default.
- W4361255955 cites W1969022350 @default.
- W4361255955 cites W1970831058 @default.
- W4361255955 cites W1970925951 @default.
- W4361255955 cites W1978245560 @default.
- W4361255955 cites W1986651658 @default.
- W4361255955 cites W1988960910 @default.
- W4361255955 cites W2004215286 @default.
- W4361255955 cites W2006216882 @default.
- W4361255955 cites W2010289839 @default.
- W4361255955 cites W2014644369 @default.
- W4361255955 cites W2017756762 @default.
- W4361255955 cites W2021170422 @default.
- W4361255955 cites W2032206017 @default.
- W4361255955 cites W2033861867 @default.
- W4361255955 cites W2035618305 @default.
- W4361255955 cites W2043612173 @default.
- W4361255955 cites W2078526277 @default.
- W4361255955 cites W2081160997 @default.
- W4361255955 cites W2090037139 @default.
- W4361255955 cites W2094534628 @default.
- W4361255955 cites W2102619694 @default.
- W4361255955 cites W2109046342 @default.
- W4361255955 cites W2109217888 @default.
- W4361255955 cites W2113153325 @default.
- W4361255955 cites W2127761410 @default.
- W4361255955 cites W2128505445 @default.
- W4361255955 cites W2134526812 @default.
- W4361255955 cites W2156475356 @default.
- W4361255955 cites W2158162478 @default.
- W4361255955 cites W2158487422 @default.
- W4361255955 cites W2158789637 @default.
- W4361255955 cites W2163412235 @default.
- W4361255955 cites W2169456326 @default.
- W4361255955 cites W2170551349 @default.
- W4361255955 cites W2179438025 @default.
- W4361255955 cites W2218568517 @default.
- W4361255955 cites W2295297857 @default.
- W4361255955 cites W2340540054 @default.
- W4361255955 cites W2401568148 @default.
- W4361255955 cites W2481029670 @default.
- W4361255955 cites W2493763501 @default.
- W4361255955 cites W2551092411 @default.
- W4361255955 cites W2556041461 @default.
- W4361255955 cites W2564735684 @default.
- W4361255955 cites W2588669653 @default.
- W4361255955 cites W2610240247 @default.
- W4361255955 cites W2612690182 @default.
- W4361255955 cites W2626627929 @default.
- W4361255955 cites W2779109505 @default.
- W4361255955 cites W2810076504 @default.
- W4361255955 cites W2899681455 @default.
- W4361255955 cites W2920191405 @default.
- W4361255955 cites W2941391556 @default.
- W4361255955 cites W2945567049 @default.
- W4361255955 cites W2951305777 @default.
- W4361255955 cites W2951322997 @default.
- W4361255955 cites W2952664869 @default.
- W4361255955 cites W2952940726 @default.
- W4361255955 cites W2962851050 @default.
- W4361255955 cites W2982290041 @default.
- W4361255955 cites W3035274148 @default.
- W4361255955 cites W3042709419 @default.
- W4361255955 cites W3082518512 @default.
- W4361255955 cites W3083199549 @default.
- W4361255955 cites W3091034669 @default.
- W4361255955 cites W3099323319 @default.
- W4361255955 cites W3131055609 @default.
- W4361255955 cites W3161556485 @default.
- W4361255955 cites W3180235698 @default.
- W4361255955 cites W3184353108 @default.
- W4361255955 cites W3195004469 @default.
- W4361255955 cites W3208292419 @default.
- W4361255955 cites W4206799282 @default.
- W4361255955 cites W4296658696 @default.
- W4361255955 cites W4308945870 @default.
- W4361255955 doi "https://doi.org/10.1016/j.celrep.2023.112323" @default.
- W4361255955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37000624" @default.
- W4361255955 hasPublicationYear "2023" @default.
- W4361255955 type Work @default.
- W4361255955 citedByCount "0" @default.
- W4361255955 crossrefType "journal-article" @default.
- W4361255955 hasAuthorship W4361255955A5012207911 @default.
- W4361255955 hasAuthorship W4361255955A5036026030 @default.
- W4361255955 hasAuthorship W4361255955A5063923189 @default.
- W4361255955 hasBestOaLocation W43612559551 @default.
- W4361255955 hasConcept C104317684 @default.
- W4361255955 hasConcept C111936080 @default.
- W4361255955 hasConcept C141231307 @default.